{"id":"fresh-frozen-plasma","safety":{"commonSideEffects":[{"rate":null,"effect":"Volume overload / fluid overload"},{"rate":null,"effect":"Transfusion-related acute lung injury (TRALI)"},{"rate":null,"effect":"Allergic reaction"},{"rate":null,"effect":"Transfusion-transmitted infection (rare with modern screening)"},{"rate":null,"effect":"Citrate toxicity (hypocalcemia)"}]},"_chembl":{"chemblId":"CHEMBL2108772","moleculeType":"Unknown"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Fresh frozen plasma (FFP) is a blood product containing all vitamin K-dependent clotting factors (II, V, VII, X), fibrinogen, and other plasma proteins. It is used to correct multiple factor deficiencies when specific factor replacement is unavailable or impractical, or in massive transfusion protocols to restore coagulation capacity and prevent dilutional coagulopathy.","oneSentence":"Fresh frozen plasma replaces deficient clotting factors and other plasma proteins to restore hemostatic function in patients with coagulopathy or massive bleeding.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:46:53.832Z","_scrapedBy":"cloudflare-swarm","_wikipedia":{"url":"https://en.wikipedia.org/wiki/Fresh_frozen_plasma","title":"Fresh frozen plasma","extract":"Fresh frozen plasma (FFP) is a blood product made from the liquid portion of whole blood. It is used to treat conditions in which there are low blood clotting factors or low levels of other blood proteins. It may also be used as the replacement fluid in plasma exchange. Using ABO compatible plasma, while not required, may be recommended. Use as a volume expander is not recommended. It is administered by slow injection into a vein."},"indications":{"approved":[{"name":"Coagulopathy with active bleeding or high bleeding risk"},{"name":"Massive transfusion / dilutional coagulopathy"},{"name":"Multiple clotting factor deficiency"},{"name":"Reversal of warfarin in emergency settings (when prothrombin complex concentrate unavailable)"},{"name":"Thrombotic thrombocytopenic purpura (TTP) plasma exchange"}]},"trialDetails":[{"nctId":"NCT07477340","phase":"","title":"Plasma Relaxin Measurement Based on Endometrial Preparation for Embryo Transfer","status":"NOT_YET_RECRUITING","sponsor":"Hospices Civils de Lyon","startDate":"2026-05-01","conditions":"Infertility, Embryos Transfert","enrollment":60},{"nctId":"NCT07094087","phase":"PHASE3","title":"Efficacy and Safety of 4F-PCC (4-Factor Prothrombin Complex Concentrate) in Adult Patients Undergoing Complex Cardiovascular Surgery With Cardiopulmonary Bypass (CPB)","status":"RECRUITING","sponsor":"CSL Behring","startDate":"2025-09-15","conditions":"Complex Cardiovascular Surgery With Cardiopulmonary Bypass","enrollment":200},{"nctId":"NCT04580563","phase":"NA","title":"Study Assessing Efficacy of Plasmatherapy in Septic Shock-induced Coagulopathy: Feasibility Study","status":"COMPLETED","sponsor":"University Hospital, Strasbourg, France","startDate":"2020-10-22","conditions":"Septic Shock, Coagulopathy, Disseminated Intravascular Coagulation","enrollment":60},{"nctId":"NCT07032792","phase":"PHASE2","title":"Factor VIII Inhibitor Bypass Activity (FEIBA) Versus Fresh Frozen Plasma As First Line Therapy For Bleeding After Cardiac Surgery","status":"RECRUITING","sponsor":"Northwell Health","startDate":"2025-11-03","conditions":"Cardiac Disease, Surgery, Bleeding","enrollment":140},{"nctId":"NCT06291025","phase":"NA","title":"Efficacy and Safety of Immunosuppression, Caplacizumab and Plasma Infusion Without Therapeutic Plasma Exchange in Immune-mediated Thrombotic Thrombocytopenic Purpura","status":"RECRUITING","sponsor":"University Hospital, Rouen","startDate":"2024-04-10","conditions":"Thrombotic Microangiopathies","enrollment":131},{"nctId":"NCT06062888","phase":"PHASE2, PHASE3","title":"FFP In Traumatic BRAin INjury (FIT-BRAIN) Trial","status":"RECRUITING","sponsor":"Northwestern University","startDate":"2026-02-01","conditions":"Moderate to Severe Traumatic Brain Injury","enrollment":357},{"nctId":"NCT06429332","phase":"PHASE4","title":"International Care Bundle Evaluation in Cerebral Hemorrhage Research","status":"RECRUITING","sponsor":"Region Skane","startDate":"2025-01-07","conditions":"Intracerebral Hemorrhage, Intracerebral Haemorrhage, Intraventricular Hemorrhage","enrollment":3500},{"nctId":"NCT07352748","phase":"","title":"Exploiting Heterogeneity in Hormone Therapy Response to Reveal Early Determinants of Drug Resistance in Advanced PCa","status":"ACTIVE_NOT_RECRUITING","sponsor":"Universita di Verona","startDate":"2024-10-17","conditions":"Metastatic Prostate Cancer","enrollment":30},{"nctId":"NCT07366008","phase":"NA","title":"The NorCUP Trial: Improving Prognosis and Personalized Treatment in Cancer of Unknown Primary (CUP)","status":"NOT_YET_RECRUITING","sponsor":"Haukeland University Hospital","startDate":"2026-01","conditions":"Cancer of Unknown Primary Site","enrollment":350},{"nctId":"NCT07329361","phase":"NA","title":"Efficacy and Safety of Intra-articular Injections of Frozen Platelet-Rich Plasma in Patients With Knee Osteoarthritis","status":"RECRUITING","sponsor":"MiKS Hospital","startDate":"2025-12-16","conditions":"Knee Osteoarthristis","enrollment":60},{"nctId":"NCT02352181","phase":"NA","title":"Management of Coagulopathy During Orthotopic Liver Transplantation. 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Syndrome","enrollment":300},{"nctId":"NCT06635707","phase":"","title":"Efficacy and Safety Study of Urapidil Alone or With Esmolol in Treating Acute Hypertensive Intracerebral Hemorrhage","status":"NOT_YET_RECRUITING","sponsor":"Qianfoshan Hospital","startDate":"2024-11-01","conditions":"Hypertensive Intracerebral Hemorrhage","enrollment":600},{"nctId":"NCT05819788","phase":"","title":"FFP Usage in Pediatric CV Surgery","status":"COMPLETED","sponsor":"University of Alberta","startDate":"2023-08-28","conditions":"Coagulopathy, Congenital Heart Disease","enrollment":431},{"nctId":"NCT02777424","phase":"PHASE4","title":"CPP Versus PFC to Correct Coagulation Disorders in Adult Neurosurgical Patients","status":"COMPLETED","sponsor":"Fondation Ophtalmologique Adolphe de Rothschild","startDate":"2016-01-21","conditions":"Intracranial Hemorrhages","enrollment":18},{"nctId":"NCT06404424","phase":"","title":"Combined Hemoperfusion and Therapeutic Plasma Exchange for Treatment of Patients With Septic Shock","status":"COMPLETED","sponsor":"Efferon JSC","startDate":"2022-05-01","conditions":"Sepsis, Septic Shock","enrollment":82},{"nctId":"NCT04202757","phase":"EARLY_PHASE1","title":"Intravenous Plasma Treatment for Parkinson's Disease","status":"COMPLETED","sponsor":"The Neurology Center","startDate":"2018-09-24","conditions":"Idiopathic Parkinson Disease","enrollment":22},{"nctId":"NCT06357572","phase":"","title":"Real-life Clinical FEIBA Samples Measured Using the Version A of the HemA EnzySystem","status":"COMPLETED","sponsor":"Enzyre B.V.","startDate":"2024-03-26","conditions":"Hemophilia A With Inhibitor, Hemophilia A","enrollment":6},{"nctId":"NCT04679311","phase":"PHASE2","title":"Treatment of Angiotensin Converting Enzyme Inhibitor-induced Angioedema","status":"TERMINATED","sponsor":"Washington University School of Medicine","startDate":"2020-12-22","conditions":"Angioedema Caused by Angiotensin-Converting-Enzyme Inhibitor","enrollment":2},{"nctId":"NCT06256796","phase":"NA","title":"Fresh Frozen Plasma Transfusion in Acute Organophosphate Poisoning","status":"UNKNOWN","sponsor":"Ain Shams University","startDate":"2024-08","conditions":"Organophosphorus Poisoning","enrollment":92},{"nctId":"NCT03996837","phase":"NA","title":"Platelet Rich Plasma and Recurrent Implantation Failure","status":"COMPLETED","sponsor":"Royan Institute","startDate":"2017-08-16","conditions":"Recurrent Implantation Failure","enrollment":80},{"nctId":"NCT06144099","phase":"PHASE4","title":"Prothrombin Complex Concentrate vs Fresh Frozen Plasma in Goal-directed Bleeding Management in Non-cardiac Surgery","status":"UNKNOWN","sponsor":"Konkuk University Medical Center","startDate":"2024-03-01","conditions":"Prostate Cancer, Spine, Open, Hip Osteoarthritis","enrollment":154},{"nctId":"NCT04107883","phase":"NA","title":"Effect of Transfusion of Plasma on Endothelial During Liver Transplantation","status":"UNKNOWN","sponsor":"Beijing Chao Yang Hospital","startDate":"2023-10-01","conditions":"End Stage Liver DIsease, Liver Transplantation","enrollment":30},{"nctId":"NCT06144125","phase":"PHASE4","title":"Prothrombin Complex Concentrate vs Fresh Frozen Plasma in Goal-directed Bleeding Management in Cardiac Surgery","status":"UNKNOWN","sponsor":"Konkuk University Medical Center","startDate":"2024-03-01","conditions":"Cardiac Valve Disease","enrollment":152},{"nctId":"NCT04456413","phase":"PHASE2","title":"Convalescent Plasma as Treatment for Subjects With Early COVID-19 Infection","status":"TERMINATED","sponsor":"Hackensack Meridian Health","startDate":"2020-11-06","conditions":"COVID-19","enrollment":21},{"nctId":"NCT04343755","phase":"PHASE2","title":"Convalescent Plasma as Treatment for Hospitalized Subjects With COVID-19 Infection","status":"TERMINATED","sponsor":"Hackensack Meridian Health","startDate":"2020-04-09","conditions":"COVID-19","enrollment":52},{"nctId":"NCT04360486","phase":"","title":"Treatment Of CORONAVIRUS DISEASE 2019 (COVID-19) With Anti-Sars-CoV-2 Convalescent Plasma (ASCoV2CP)","status":"NO_LONGER_AVAILABLE","sponsor":"U.S. Army Medical Research and Development Command","startDate":"","conditions":"Severe Acute Respiratory Syndrome Coronavirus 2","enrollment":""},{"nctId":"NCT05840640","phase":"PHASE4","title":"Granulocyte Colony Stimulating Factor Four Week Plus N-Acetyl Cysteine in Severe Alcoholic Hepatitis","status":"COMPLETED","sponsor":"Post Graduate Institute of Medical Education and Research, Chandigarh","startDate":"2017-10-01","conditions":"Alcoholic Hepatitis","enrollment":66},{"nctId":"NCT00618098","phase":"PHASE3","title":"Study of Octaplex (Human Prothrombin Complex Concentrate) and Fresh Frozen Plasma in Patients Under Vitamin K Therapy Antagonist Needing Urgent Surgery or Invasive Procedures","status":"COMPLETED","sponsor":"Octapharma","startDate":"2008-05","conditions":"Reversal of Anticoagulant Treatment","enrollment":200},{"nctId":"NCT03209258","phase":"NA","title":"The Third, Intensive Care Bundle With Blood Pressure Reduction in Acute Cerebral Hemorrhage Trial","status":"COMPLETED","sponsor":"The George Institute for Global Health, China","startDate":"2017-12-12","conditions":"Cerebral Hemorrhage, Stroke, Hypertension","enrollment":7067},{"nctId":"NCT04174989","phase":"NA","title":"Clinical Investigation of Safety and Performance of a Medical Device (ClearPlasma) for the Treatment of Patients With Acute Upper Gastrointestinal Hemorrhage.","status":"COMPLETED","sponsor":"PlasFree Ltd.","startDate":"2020-10-24","conditions":"Acute Upper Gastrointestinal Hemorrhage, Acute Upper Gastrointestinal Bleeding","enrollment":53},{"nctId":"NCT05382013","phase":"PHASE4","title":"Efficacy and Safety of Avatrombopag for Treating TCP in HBV-ACLF Patients Receiving ALSS Treatment","status":"UNKNOWN","sponsor":"Third Affiliated Hospital, Sun Yat-Sen University","startDate":"2022-04-27","conditions":"Thrombocytopenia, Hepatitis B, Chronic, Acute-On-Chronic Liver Failure","enrollment":60},{"nctId":"NCT04472572","phase":"","title":"Expanded Access to Convalescent Plasma for Treatment of COVID-19","status":"NO_LONGER_AVAILABLE","sponsor":"Hackensack Meridian Health","startDate":"","conditions":"COVID-19","enrollment":""},{"nctId":"NCT04421404","phase":"PHASE2","title":"Effects of COVID-19 Convalescent Plasma (CCP) on Coronavirus-associated Complications in Hospitalized Patients","status":"COMPLETED","sponsor":"Priscilla Hsue, MD","startDate":"2020-06-09","conditions":"COVID-19, Sars-CoV2","enrollment":34},{"nctId":"NCT04109144","phase":"PHASE2","title":"Fresh Frozen Plasma as a Substitute for Albumin in Patients Receiving a Large Volume Paracentesis","status":"WITHDRAWN","sponsor":"Montefiore Medical Center","startDate":"2019-11-11","conditions":"Liver Cirrhosis, Ascites Hepatic","enrollment":""},{"nctId":"NCT04683614","phase":"NA","title":"Intraoperative Norepinephrine Versus Fresh Frozen Plasma in Patients Undergoing HIPEC to Reduce Renal Insult","status":"COMPLETED","sponsor":"National Cancer Institute, Egypt","startDate":"2020-10-20","conditions":"Anesthesia","enrollment":60},{"nctId":"NCT02557672","phase":"PHASE4","title":"PCC vs. FFP for Post Cardiopulmonary Bypass Coagulopathy and Bleeding","status":"COMPLETED","sponsor":"Mayo Clinic","startDate":"2016-08","conditions":"Bleeding, Blood Loss, Surgical, Cardiovascular Surgical Procedures","enrollment":106},{"nctId":"NCT05392673","phase":"NA","title":"Efficacy and Economic Evaluation of Nonbiological Artificial Liver Therapy in Acute-on-chronic Hepatitis B Liver Failure.","status":"COMPLETED","sponsor":"Xiangya Hospital of Central South University","startDate":"2020-06-01","conditions":"Chronic-on-acute Liver Failure","enrollment":186},{"nctId":"NCT04457349","phase":"NA","title":"Therapeutic Plasma Exchange in Resistant Cytokine Storm of COVID 19","status":"COMPLETED","sponsor":"Alexandria University","startDate":"2020-07-25","conditions":"COVID 19","enrollment":10},{"nctId":"NCT04374539","phase":"PHASE2","title":"Plasma Exchange in Patients With COVID-19 Disease and Invasive Mechanical Ventilation: a Randomized Controlled Trial","status":"TERMINATED","sponsor":"Fundacion Clinic per a la Recerca Biomédica","startDate":"2020-04-29","conditions":"Coronavirus","enrollment":36},{"nctId":"NCT04589949","phase":"PHASE3","title":"Early Convalescent Plasma Therapy for High-risk Patients With COVID-19 in Primary Care (the CoV-Early Study)","status":"TERMINATED","sponsor":"Erasmus Medical Center","startDate":"2020-10-12","conditions":"Covid19","enrollment":420},{"nctId":"NCT02878603","phase":"PHASE3","title":"Follow-up Study for Patients Who Completed Study ALX0681-C301 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