{"id":"french-lyophilized-plasma","safety":{"commonSideEffects":[{"rate":null,"effect":"Transfusion-related acute lung injury (TRALI)"},{"rate":null,"effect":"Allergic/anaphylactic reactions"},{"rate":null,"effect":"Thromboembolic events"},{"rate":null,"effect":"Fluid overload"}]},"_chembl":{"chemblId":"CHEMBL2108772","moleculeType":"Unknown"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"This is a freeze-dried (lyophilized) human plasma product that contains multiple coagulation factors, fibrinogen, and other plasma proteins. When reconstituted, it restores the balance of clotting factors needed for normal hemostasis, making it useful in acute bleeding scenarios where specific factor replacement is not immediately available or where multiple factor deficiencies exist.","oneSentence":"French Lyophilized Plasma replaces clotting factors and other plasma proteins to restore hemostatic function in patients with coagulopathy or massive hemorrhage.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T00:47:04.406Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Massive hemorrhage and coagulopathy"},{"name":"Acute bleeding in patients with multiple clotting factor deficiencies"},{"name":"Perioperative hemostatic support"}]},"trialDetails":[{"nctId":"NCT02736812","phase":"PHASE3","title":"Pre-hospital Administration of Lyophilized Plasma for Post-traumatic Coagulopathy Treatment (PREHO-PLYO)","status":"COMPLETED","sponsor":"French Defence Health Service","startDate":"2016-04-01","conditions":"Shock Hemorrhagic","enrollment":140}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"French Lyophilized Plasma","genericName":"French Lyophilized Plasma","companyName":"French Defence Health Service","companyId":"french-defence-health-service","modality":"Biologic","firstApprovalDate":"","aiSummary":"French Lyophilized Plasma replaces clotting factors and other plasma proteins to restore hemostatic function in patients with coagulopathy or massive hemorrhage. Used for Massive hemorrhage and coagulopathy, Acute bleeding in patients with multiple clotting factor deficiencies, Perioperative hemostatic support.","enrichmentLevel":3,"visitCount":2,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}