{"id":"free-per-ind-aml","safety":{"commonSideEffects":[{"rate":null,"effect":"Cough"},{"rate":null,"effect":"Peripheral edema"},{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Fatigue"}]},"_chembl":{"chemblId":"CHEMBL5082715","moleculeType":"Unknown","molecularWeight":"398.50"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Perindopril inhibits angiotensin-converting enzyme, preventing formation of angiotensin II and reducing vasoconstriction and aldosterone secretion. Amlodipine blocks L-type calcium channels in vascular smooth muscle, causing direct vasodilation. Together, these complementary mechanisms provide synergistic blood pressure reduction with improved tolerability compared to monotherapy.","oneSentence":"A fixed-dose combination of perindopril (ACE inhibitor) and amlodipine (calcium channel blocker) that reduces blood pressure through dual vasodilation and renin-angiotensin system inhibition.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:13:25.288Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Hypertension"}]},"trialDetails":[],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1490915,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Free [Per/Ind + Aml]","genericName":"Free [Per/Ind + Aml]","companyName":"Institut de Recherches Internationales Servier","companyId":"institut-de-recherches-internationales-servier","modality":"Small molecule","firstApprovalDate":"","aiSummary":"There is limited information available on the modality of Free [Per/Ind + Aml] due to unknown data on ChEMBL.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":false,"score":3}}