{"id":"fospropofol","rwe":[{"pmid":"41792813","year":"2026","title":"Efficacy and safety of fospropofol disodium versus propofol for general anesthesia induction: a systematic review and meta-analysis.","finding":"","journal":"European journal of medical research","studyType":"Clinical Study"},{"pmid":"41754882","year":"2026","title":"Novel Propofol Analogs: Design, Synthesis and Evaluation of Dihydrobenzofuran Derivatives as General Anesthetics.","finding":"","journal":"Pharmaceuticals (Basel, Switzerland)","studyType":"Clinical Study"},{"pmid":"41654755","year":"2026","title":"Comparing the efficacy of fospropofol with propofol and midazolam for goal-directed sedation in critically ill patients: a prospective, open-label, pilot, randomized controlled trial.","finding":"","journal":"BMC anesthesiology","studyType":"Clinical Study"},{"pmid":"41586742","year":"2026","title":"Guideline-Concordant Sedative and Analgesia Use in Critically Ill Patients Receiving Sustained Neuromuscular Blockade.","finding":"","journal":"Critical care explorations","studyType":"Clinical Study"},{"pmid":"41513526","year":"2026","title":"Fospropofol Disodium for Anesthesia Induction in Liver Transplant Recipients - A Case Series.","finding":"","journal":"Transplantation proceedings","studyType":"Clinical Study"}],"tags":[{"label":"fospropofol","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"GABA-A receptor","category":"target"},{"label":"GABRA1","category":"gene"},{"label":"GABRA2","category":"gene"},{"label":"GABRA3","category":"gene"},{"label":"Off-Patent","category":"patent"},{"label":"Active","category":"status"},{"label":"Sedation as Adjunct to Anesthesia","category":"indication"},{"label":"Approved 2000s","category":"decade"},{"label":"Central Nervous System Agents","category":"pharmacology"},{"label":"Central Nervous System Depressants","category":"pharmacology"},{"label":"Hypnotics and Sedatives","category":"pharmacology"}],"phase":"marketed","safety":{"contraindications":["Apnea","Decreased respiratory function","Hypovolemia","Hypoxia","Low blood pressure","Myocardial dysfunction"]},"trials":[],"aliases":[],"patents":[],"pricing":[],"_sources":{"trials":{"url":"https://clinicaltrials.gov/search?intr=FOSPROPOFOL","method":"api_direct","source":"ClinicalTrials.gov","rawText":"","confidence":1,"sourceType":"ctgov","retrievedAt":"2026-04-20T01:19:25.698625+00:00"},"regulatory.ca":{"url":"","method":"api_direct","source":"Health Canada DPD","rawText":"","confidence":1,"sourceType":"health_canada_dpd","retrievedAt":"2026-04-20T01:19:32.274371+00:00"},"publicationCount":{"url":"https://pubmed.ncbi.nlm.nih.gov/?term=FOSPROPOFOL","method":"api_direct","source":"PubMed/NCBI","rawText":"","confidence":1,"sourceType":"pubmed","retrievedAt":"2026-04-20T01:19:32.623544+00:00"},"crossReferences.chemblId":{"url":"https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL1201766/","method":"api_direct","source":"ChEMBL (EMBL-EBI)","rawText":"","confidence":1,"sourceType":"chembl","retrievedAt":"2026-04-20T01:19:33.324826+00:00"}},"allNames":"lusedra","offLabel":[],"synonyms":["fospropofol sodium","fospropofol","fospropofol disodium","lusedra"],"timeline":[{"date":"2008-12-12","type":"positive","source":"DrugCentral","milestone":"FDA approval"}],"aiSummary":"Lusedra (FOSPROPOFOL) is a small molecule drug that targets the GABA-A receptor, classified as a fospropofol. 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