{"id":"fosfosal","rwe":[{"pmid":"40409217","year":"2025","title":"In silico study of salicylic acid derivatives as inhibitors of Ebola proteins through molecular docking.","finding":"","journal":"Computational biology and chemistry","studyType":"Clinical Study"},{"pmid":"37668977","year":"2023","title":"Dissecting Selectivity Determinants of Small-Molecule Inhibitors of SH2 Domains Via Fluorescence Polarization Assays.","finding":"","journal":"Methods in molecular biology (Clifton, N.J.)","studyType":"Clinical Study"},{"pmid":"32766282","year":"2020","title":"High-Throughput Screening of a Functional Human CXCL12-CXCR4 Signaling Axis in a Genetically Modified S. cerevisiae: Discovery of a Novel Up-Regulator of CXCR4 Activity.","finding":"","journal":"Frontiers in molecular biosciences","studyType":"Clinical Study"},{"pmid":"32227557","year":"2020","title":"The Selectivity of Fosfosal for STAT5b over STAT5a is Mediated by Arg566 in the Linker Domain.","finding":"","journal":"Chembiochem : a European journal of chemical biology","studyType":"Clinical Study"},{"pmid":"30246144","year":"2016","title":"Detection of Alkaline Phosphatase Enzyme Activity with a CatalyCEST MRI Biosensor.","finding":"","journal":"ACS sensors","studyType":"Clinical Study"}],"tags":[{"label":"fosfosal","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"disdolen","offLabel":[],"synonyms":["fosfosal","disdolen","phosphoric acid o-carboxyphenyl ester","salicyl phosphate","2-Phosphonoxybenzoic acid","2-Carboxyphenyl dihydrogen phosphate"],"timeline":[],"approvals":[],"brandName":"Disdolen","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"fosfosal","explanation":"Imagine your body's physiological processes as a complex orchestra. Disdolen (FOSFOSAL) is like a conductor that helps the different parts work together, but we don't know exactly how it does this or what specific parts it affects. This is a simplified explanation, and the actual mechanism is likely much more complex.","oneSentence":"Disdolen (FOSFOSAL) is thought to work by modulating physiological processes, but the exact mechanism is unknown.","technicalDetail":"As a fosfosal, Disdolen (FOSFOSAL) may interact with cellular receptors or enzymes to modulate physiological processes, but the specific molecular details are unknown."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/1244","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=FOSFOSAL","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T11:38:48.266529","biosimilars":[],"competitors":[],"genericName":"fosfosal","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"UNII":"124X2V25W4","CHEBI":"CHEBI:94564","INN_ID":"4265","UMLSCUI":"C0045981","ChEMBL_ID":"CHEMBL287275","KEGG_DRUG":"D07991","PUBCHEM_CID":"3418","MESH_SUPPLEMENTAL_RECORD_UI":"C000380"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":20,"therapeuticAreas":["Other"],"biosimilarFilings":[],"recentPublications":[{"date":"2025 Dec","pmid":"40409217","title":"In silico study of salicylic acid derivatives as inhibitors of Ebola proteins through molecular docking.","journal":"Computational biology and chemistry"},{"date":"2023","pmid":"37668977","title":"Dissecting Selectivity Determinants of Small-Molecule Inhibitors of SH2 Domains Via Fluorescence Polarization Assays.","journal":"Methods in molecular biology (Clifton, N.J.)"},{"date":"2020","pmid":"32766282","title":"High-Throughput Screening of a Functional Human CXCL12-CXCR4 Signaling Axis in a Genetically Modified S. cerevisiae: Discovery of a Novel Up-Regulator of CXCR4 Activity.","journal":"Frontiers in molecular biosciences"},{"date":"2020 Aug 17","pmid":"32227557","title":"The Selectivity of Fosfosal for STAT5b over STAT5a is Mediated by Arg566 in the Linker Domain.","journal":"Chembiochem : a European journal of chemical biology"},{"date":"2016 Jul 22","pmid":"30246144","title":"Detection of Alkaline Phosphatase Enzyme Activity with a CatalyCEST MRI Biosensor.","journal":"ACS sensors"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Disdolen (FOSFOSAL) is a small molecule drug in the fosfosal class, but details about its target, FDA approval status, and approved indications are unknown. Its commercial status, generic manufacturers, and patent status are also unclear. As a fosfosal, it is likely involved in modulating physiological processes, but specific mechanisms and safety considerations are not well-documented. Further research is needed to understand its therapeutic potential and safety profile. Its development and ownership history are also unclear.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}