{"id":"fosfomycun-trometamol","safety":{"commonSideEffects":[{"rate":null,"effect":"Diarrhea"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Vaginitis"},{"rate":null,"effect":"Abdominal pain"}]},"_chembl":{"chemblId":"CHEMBL3186668","moleculeType":"Small molecule","molecularWeight":"475.62"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Fosfomycin trometamol works by inhibiting the enzyme MurA (UDP-N-acetylglucosamine enolpyruvyl transferase), which is essential for the early stages of bacterial peptidoglycan synthesis. This disruption of cell wall formation leads to bacterial cell death. The trometamol salt formulation enhances oral bioavailability and urinary concentration, making it particularly effective for urinary tract infections.","oneSentence":"Fosfomycin trometamol is a broad-spectrum antibiotic that inhibits bacterial cell wall synthesis by blocking peptidoglycan cross-linking.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:13:18.813Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Uncomplicated urinary tract infections (acute cystitis)"},{"name":"Bacterial urinary tract infections in women"}]},"trialDetails":[{"nctId":"NCT06822751","phase":"PHASE3","title":"FOsfomycin for Male Urinary Tract Infection","status":"NOT_YET_RECRUITING","sponsor":"University Hospital, Rouen","startDate":"2026-03","conditions":"Urinary Tract Infection, Prostatitis, Cystitis","enrollment":138}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Fosfomycun-trometamol","genericName":"Fosfomycun-trometamol","companyName":"University Hospital, Rouen","companyId":"university-hospital-rouen","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Fosfomycin trometamol is a broad-spectrum antibiotic that inhibits bacterial cell wall synthesis by blocking peptidoglycan cross-linking. Used for Uncomplicated urinary tract infections (acute cystitis), Bacterial urinary tract infections in women.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}