{"id":"fosfomycin-oral-suspension","safety":{"commonSideEffects":[{"rate":null,"effect":"Diarrhea"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Vaginitis"}]},"_chembl":{"chemblId":"CHEMBL1757","moleculeType":"Small molecule","molecularWeight":"138.06"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Fosfomycin is a broad-spectrum antibiotic that works by disrupting bacterial cell wall formation. It binds to and inactivates MurA (enolpyruvate transferase), an essential enzyme in the early stages of peptidoglycan synthesis. This mechanism is distinct from beta-lactams and allows activity against many gram-positive and gram-negative bacteria, including some resistant strains.","oneSentence":"Fosfomycin inhibits bacterial cell wall synthesis by inactivating the enzyme enolpyruvate transferase, preventing peptidoglycan cross-linking.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:39:43.986Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Uncomplicated urinary tract infections (acute cystitis)"},{"name":"Bacterial infections susceptible to fosfomycin"}]},"trialDetails":[{"nctId":"NCT03294395","phase":"PHASE3","title":"New AntiBiotic Treatment Options for Uncomplicated Anogenital GOnorrhoea","status":"COMPLETED","sponsor":"Public Health Service of Amsterdam","startDate":"2017-09-18","conditions":"Gonorrhea","enrollment":346},{"nctId":"NCT03868969","phase":"PHASE2","title":"Clinical Efficacy of Fosfomycin Trometamol Per os in the Treatment of Documented Male Urinary Tract Infections With ESBL-producing Enterobacteriaceae With ESBL Producing Enterobacteriaceae and Resistance Associated With Fluoroquinolones and Cotrimoxazole (FOSF'HOM)","status":"UNKNOWN","sponsor":"Centre Hospitalier Universitaire de Besancon","startDate":"2019-04","conditions":"Urinary Tract Infections","enrollment":25}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Monuril"],"phase":"marketed","status":"active","brandName":"Fosfomycin Oral Suspension","genericName":"Fosfomycin Oral Suspension","companyName":"Public Health Service of Amsterdam","companyId":"public-health-service-of-amsterdam","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Fosfomycin inhibits bacterial cell wall synthesis by inactivating the enzyme enolpyruvate transferase, preventing peptidoglycan cross-linking. Used for Uncomplicated urinary tract infections (acute cystitis), Bacterial infections susceptible to fosfomycin.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}