{"id":"formebolone","rwe":[{"pmid":"21167991","year":"2011","title":"Comparison between triple quadrupole, time of flight and hybrid quadrupole time of flight analysers coupled to liquid chromatography for the detection of anabolic steroids in doping control analysis.","finding":"","journal":"Analytica chimica acta","studyType":"Clinical Study"},{"pmid":"15013688","year":"2004","title":"Screening of free 17-alkyl-substituted anabolic steroids in human urine by liquid chromatography-electrospray ionization tandem mass spectrometry.","finding":"","journal":"Steroids","studyType":"Clinical Study"},{"pmid":"3985494","year":"1985","title":"[Study of non-hypophysiary growth retardation treated with formebolone].","finding":"","journal":"Anales espanoles de pediatria","studyType":"Clinical Study"},{"pmid":"454541","year":"1979","title":"[Study on potential and real impurities present in a synthetic steroid: formebolone].","finding":"","journal":"Bollettino chimico farmaceutico","studyType":"Clinical Study"},{"pmid":"854006","year":"1977","title":"[Effect of Formebolone in 16 infants with malnutrition].","finding":"","journal":"Minerva pediatrica","studyType":"Clinical Study"}],"tags":[{"label":"formebolone","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"esiclene","offLabel":[],"synonyms":["formildienolone","formebolone","esiclene","formyldienolone"],"timeline":[],"approvals":[],"brandName":"Esiclene","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"formebolone","explanation":"Imagine your body has a thermostat that regulates inflammation and stress. Esiclene is like a special key that fits into this thermostat, but instead of turning it up or down, it helps the thermostat work more smoothly and efficiently. This can help reduce inflammation and alleviate symptoms associated with certain conditions.","oneSentence":"Esiclene works by mimicking the effects of cortisol in the body, but with a modified structure that may reduce side effects.","technicalDetail":"Esiclene is a synthetic glucocorticoid that binds to glucocorticoid receptors, activating a cascade of downstream effects that modulate inflammation, immune response, and other physiological processes."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/1237","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=FORMEBOLONE","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=FORMEBOLONE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T11:35:53.479616","biosimilars":[],"competitors":[],"genericName":"formebolone","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[{"nctId":"NCT04225793","phase":"NA","title":"The Use of Osmotic Laxatives Versus Macrogol for Bowel Preparation in Patients Undergoing Colonoscopy","status":"UNKNOWN","sponsor":"Russian Society of Colorectal Surgeons","startDate":"2019-06-02","conditions":["Colorectal Disorders"],"enrollment":98,"completionDate":"2020-08-02"}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"UNII":"Z2MMV08KUQ","CHEBI":"CHEBI:135456","INN_ID":"3604","UMLSCUI":"C0060670","ChEMBL_ID":"CHEMBL2107419","DRUGBANK_ID":"DB01569","PUBCHEM_CID":"17150","MESH_SUPPLEMENTAL_RECORD_UI":"C002846"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":10,"therapeuticAreas":["Immunology"],"biosimilarFilings":[],"recentPublications":[{"date":"2011 Jan 17","pmid":"21167991","title":"Comparison between triple quadrupole, time of flight and hybrid quadrupole time of flight analysers coupled to liquid chromatography for the detection of anabolic steroids in doping control analysis.","journal":"Analytica chimica acta"},{"date":"2004 Feb","pmid":"15013688","title":"Screening of free 17-alkyl-substituted anabolic steroids in human urine by liquid chromatography-electrospray ionization tandem mass spectrometry.","journal":"Steroids"},{"date":"1985 Jan","pmid":"3985494","title":"[Study of non-hypophysiary growth retardation treated with formebolone].","journal":"Anales espanoles de pediatria"},{"date":"1979 Apr","pmid":"454541","title":"[Study on potential and real impurities present in a synthetic steroid: formebolone].","journal":"Bollettino chimico farmaceutico"},{"date":"1977 Feb 18","pmid":"854006","title":"[Effect of Formebolone in 16 infants with malnutrition].","journal":"Minerva pediatrica"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Esiclene, also known as formebolone, is a small molecule drug in the formebolone class. It was originally developed by, but its current owner is unknown. The exact target of Esiclene is not specified, and it is not FDA-approved for any indications. As a result, there is limited information available on its commercial status, pharmacokinetics, or safety profile. Further research is needed to fully understand Esiclene's properties and potential uses.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":true,"score":2}}