{"id":"fomivirsen","rwe":[],"tags":[{"label":"fomivirsen","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"S01AD08","category":"atc"},{"label":"Off-Patent","category":"patent"},{"label":"Active","category":"status"},{"label":"Cytomegaloviral retinitis","category":"indication"},{"label":"Novartis","category":"company"},{"label":"Approved 1990s","category":"decade"},{"label":"Anti-Infective Agents","category":"pharmacology"},{"label":"Antiviral Agents","category":"pharmacology"},{"label":"Molecular Probes","category":"pharmacology"},{"label":"Oligonucleotides, Antisense","category":"pharmacology"}],"phase":"marketed","safety":{},"trials":[],"aliases":[],"company":"Novartis","patents":[],"pricing":[],"_sources":{"trials":{"url":"https://clinicaltrials.gov/search?intr=FOMIVIRSEN","method":"api_direct","source":"ClinicalTrials.gov","rawText":"","confidence":1,"sourceType":"ctgov","retrievedAt":"2026-04-20T03:46:36.895868+00:00"},"regulatory.ca":{"url":"","method":"api_direct","source":"Health Canada DPD","rawText":"","confidence":1,"sourceType":"health_canada_dpd","retrievedAt":"2026-04-20T03:46:42.817672+00:00"},"publicationCount":{"url":"https://pubmed.ncbi.nlm.nih.gov/?term=FOMIVIRSEN","method":"api_direct","source":"PubMed/NCBI","rawText":"","confidence":1,"sourceType":"pubmed","retrievedAt":"2026-04-20T03:46:43.534948+00:00"},"mechanism.target_chembl":{"url":"","method":"api_direct","source":"ChEMBL mechanism: Major intermediate early region 2 mRNA antisense inhibitor","rawText":"","confidence":1,"sourceType":"chembl","retrievedAt":"2026-04-20T03:46:44.575383+00:00"},"crossReferences.chemblId":{"url":"https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL1201688/","method":"api_direct","source":"ChEMBL (EMBL-EBI)","rawText":"","confidence":1,"sourceType":"chembl","retrievedAt":"2026-04-20T03:46:44.228667+00:00"}},"allNames":["fomivirsen sodium","fomivirsen"],"offLabel":[],"synonyms":["fomivirsen sodium","fomivirsen"],"timeline":[{"date":"1998-08-26","type":"positive","source":"DrugCentral","milestone":"FDA approval (Novartis)"}],"aiSummary":"Fomivirsen is a small molecule drug originally developed by Novartis and currently owned by the same company. It is classified as a fomivirsen and was FDA approved in 1998 for the treatment of cytomegaloviral retinitis. Fomivirsen is off-patent and has no active Orange Book patents, but there are no generic manufacturers available. It is used to treat a specific eye infection caused by the cytomegalovirus. As an off-patent drug with no generic alternatives, its commercial status is limited.","approvals":[{"date":"1998-08-26","orphan":false,"company":"NOVARTIS","regulator":"FDA"}],"ecosystem":[{"indication":"Cytomegaloviral retinitis","otherDrugs":[{"name":"ganciclovir","slug":"ganciclovir","company":"Roche Palo"}],"globalPrevalence":null}],"mechanism":{"novelty":"Follow-on","modality":"Small Molecule","drugClass":"fomivirsen","explanation":"","oneSentence":"","technicalDetail":"Fomivirsen is an antisense oligonucleotide that binds to the mRNA of the cytomegalovirus, specifically targeting the UL97 gene, which is essential for viral replication."},"commercial":{"launchDate":"1998","_launchSource":"DrugCentral (FDA 1998-08-26, 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