{"id":"folotyn-and-leucovorin","safety":{"commonSideEffects":[{"rate":"40-60%","effect":"Neutropenia"},{"rate":"30-50%","effect":"Thrombocytopenia"},{"rate":"20-40%","effect":"Anemia"},{"rate":"20-40%","effect":"Fatigue"},{"rate":"10-30%","effect":"Nausea"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"Folotyn works by binding to DNA and inhibiting RNA synthesis, which ultimately leads to cell death. Leucovorin, on the other hand, is used to enhance the effectiveness of folate-dependent drugs like methotrexate, which is often used in combination with Folotyn in the treatment of certain cancers.","oneSentence":"Folotyn is a pegylated form of calicheamicin, a potent antitumor antibiotic that binds to DNA and inhibits RNA synthesis, while Leucovorin is a folate analog that inhibits dihydrofolate reductase, thereby increasing the effectiveness of folate-dependent drugs.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T03:32:44.344Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Relapsed or refractory peripheral T-cell lymphoma"},{"name":"Relapsed or refractory cutaneous T-cell lymphoma"}]},"trialDetails":[{"nctId":"NCT03161223","phase":"PHASE1, PHASE2","title":"Durvalumab in Different Combinations With Pralatrexate, Romidepsin and Oral 5-Azacitidine for Lymphoma","status":"RECRUITING","sponsor":"University of Virginia","startDate":"2018-05-30","conditions":"Lymphoma, T-Cell","enrollment":148},{"nctId":"NCT01789723","phase":"PHASE1","title":"Phase 1 Study of Fusilev to Prevent or Reduce Mucositis in Patients With Non-Hodgkin's Lymphoma Receiving Folotyn","status":"WITHDRAWN","sponsor":"Acrotech Biopharma Inc.","startDate":"2013-03","conditions":"Non Hodgkin's Lymphoma","enrollment":""},{"nctId":"NCT01820091","phase":"PHASE1","title":"Phase 1 Study of Fusilev® to Prevent or Reduce Mucositis in Patients With Non-Small Cell Lung Cancer Receiving Folotyn®","status":"WITHDRAWN","sponsor":"Acrotech Biopharma Inc.","startDate":"2013-04","conditions":"Non-Small Cell Lung Cancer","enrollment":""},{"nctId":"NCT02106650","phase":"PHASE2","title":"Phase II Study of Folotyn With Leucovorin to Prevent/Reduce Mucositis in Patients With Hematological Malignancies","status":"COMPLETED","sponsor":"Acrotech Biopharma Inc.","startDate":"2014-07","conditions":"Relapsed Peripheral T-Cell Lymphoma, Refractory Peripheral T-Cell Lymphoma","enrollment":36}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Pralatrexate (Folotyn)"],"phase":"phase_2","status":"active","brandName":"Folotyn and Leucovorin","genericName":"Folotyn and Leucovorin","companyName":"Acrotech Biopharma Inc.","companyId":"acrotech-biopharma-inc","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Folotyn is a pegylated form of calicheamicin, a potent antitumor antibiotic that binds to DNA and inhibits RNA synthesis, while Leucovorin is a folate analog that inhibits dihydrofolate reductase, thereby increasing the effectiveness of folate-dependent drugs. Used for Relapsed or refractory peripheral T-cell lymphoma, Relapsed or refractory cutaneous T-cell lymphoma.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}