{"id":"follitropin-beta-liquid-formulation","safety":{"commonSideEffects":[{"rate":null,"effect":"Ovarian hyperstimulation syndrome (OHSS)"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Injection site reactions"},{"rate":null,"effect":"Abdominal pain/bloating"},{"rate":null,"effect":"Nausea"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Follitropin beta binds to FSH receptors on granulosa cells of ovarian follicles and Sertoli cells in the testes, triggering intracellular signaling cascades that promote follicular development and steroidogenesis. In women, this leads to estrogen production and ovulation; in men, it supports sperm production. The liquid formulation offers an alternative delivery method to powder formulations, potentially improving convenience and dose accuracy.","oneSentence":"Follitropin beta is a recombinant human follicle-stimulating hormone (FSH) that stimulates the growth and maturation of ovarian follicles in women and spermatogenesis in men.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:13:20.183Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Infertility in women undergoing assisted reproductive technology (ART)"},{"name":"Infertility in men with hypogonadotropic hypogonadism"}]},"trialDetails":[{"nctId":"NCT04899193","phase":"PHASE1","title":"Pergoveris FD and Liquid China BE Study","status":"COMPLETED","sponsor":"Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany","startDate":"2021-05-08","conditions":"Healthy","enrollment":72},{"nctId":"NCT01183143","phase":"PHASE3","title":"Convenience and Safety of Assisted Reproductive Technology Procedures Using a Gonal-F Filled by Mass (Fbm) Liquid Formulation Applied by Pen for Ovulation Induction and In-vitro Fertilization","status":"COMPLETED","sponsor":"Merck KGaA, Darmstadt, Germany","startDate":"2004-05-11","conditions":"Infertility, Ovulation Induction, In-Vitro Fertilization","enrollment":215},{"nctId":"NCT01081639","phase":"PHASE3","title":"To Evaluate the Convenience, Safety and Efficacy of Follitropin Alfa Liquid Pen Compared With Follitropin Beta Liquid Pen","status":"COMPLETED","sponsor":"Merck KGaA, Darmstadt, Germany","startDate":"2003-11","conditions":"Infertility, Ovulation Induction","enrollment":34}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Puregon"],"phase":"phase_3","status":"active","brandName":"Follitropin beta liquid formulation","genericName":"Follitropin beta liquid formulation","companyName":"Merck KGaA, Darmstadt, Germany","companyId":"merck-kgaa-darmstadt-germany","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Follitropin beta liquid formulation is a follicle-stimulating hormone receptor agonist, classified as an agonist drug. It is used to treat conditions such as infertility, ovulation induction, and in-vitro fertilization.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}