{"id":"follitropin-alfa-liquid-formulation","safety":{"commonSideEffects":[{"rate":"5-10","effect":"Ovarian hyperstimulation syndrome (OHSS)"},{"rate":"10-15","effect":"Headache"},{"rate":"5-10","effect":"Injection site reactions"},{"rate":"10-20","effect":"Abdominal pain/discomfort"},{"rate":"5-10","effect":"Nausea"},{"rate":"5-15","effect":"Ovarian cysts"}]},"_chembl":{"chemblId":"CHEMBL1201692","moleculeType":"Protein"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Follitropin alfa binds to FSH receptors on granulosa cells of ovarian follicles, promoting their growth and maturation. This leads to increased estrogen secretion and development of multiple follicles, which is essential for controlled ovarian hyperstimulation in assisted reproductive technology. The liquid formulation allows for flexible dosing and may improve patient convenience compared to powder formulations.","oneSentence":"Follitropin alfa is a recombinant human follicle-stimulating hormone (FSH) that stimulates ovarian follicle development and estrogen production in women.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:13:14.577Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Infertility in women undergoing assisted reproductive technology (ART) / in vitro fertilization (IVF)"},{"name":"Anovulation and ovulatory dysfunction in women"}]},"trialDetails":[{"nctId":"NCT04899193","phase":"PHASE1","title":"Pergoveris FD and Liquid China BE Study","status":"COMPLETED","sponsor":"Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany","startDate":"2021-05-08","conditions":"Healthy","enrollment":72},{"nctId":"NCT01183143","phase":"PHASE3","title":"Convenience and Safety of Assisted Reproductive Technology Procedures Using a Gonal-F Filled by Mass (Fbm) Liquid Formulation Applied by Pen for Ovulation Induction and In-vitro Fertilization","status":"COMPLETED","sponsor":"Merck KGaA, Darmstadt, Germany","startDate":"2004-05-11","conditions":"Infertility, Ovulation Induction, In-Vitro Fertilization","enrollment":215},{"nctId":"NCT01081639","phase":"PHASE3","title":"To Evaluate the Convenience, Safety and Efficacy of Follitropin Alfa Liquid Pen Compared With Follitropin Beta Liquid Pen","status":"COMPLETED","sponsor":"Merck KGaA, Darmstadt, Germany","startDate":"2003-11","conditions":"Infertility, Ovulation Induction","enrollment":34}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Gonal-f"],"phase":"phase_3","status":"active","brandName":"Follitropin alfa liquid formulation","genericName":"Follitropin alfa liquid formulation","companyName":"Merck KGaA, Darmstadt, Germany","companyId":"merck-kgaa-darmstadt-germany","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Follitropin alfa is a recombinant human follicle-stimulating hormone (FSH) that stimulates ovarian follicle development and estrogen production in women. Used for Infertility in women undergoing assisted reproductive technology (ART) / in vitro fertilization (IVF), Anovulation and ovulatory dysfunction in women.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}