{"id":"fol-005","safety":{"commonSideEffects":[{"rate":null,"effect":"Local skin irritation"},{"rate":null,"effect":"Erythema at application site"},{"rate":null,"effect":"Pruritus"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"anthropic-haiku","explanation":"FOL-005 works by activating the Wnt/β-catenin signaling pathway, a key developmental pathway involved in hair follicle morphogenesis and growth. By enhancing this pathway, the drug aims to promote hair follicle activation and proliferation, potentially reversing hair loss in androgenetic alopecia and other forms of alopecia.","oneSentence":"FOL-005 is a Wnt/β-catenin signaling activator designed to stimulate hair follicle growth and treat hair loss.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T03:32:29.631Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Androgenetic alopecia (male and female pattern hair loss)"}]},"trialDetails":[{"nctId":"NCT04774874","phase":"PHASE2","title":"A Phase 2a Trial of FOL-005 Topical Formulations to Investigate Hair Growth Potential and Safety in Healthy Male Volunteers","status":"COMPLETED","sponsor":"Follicum AB","startDate":"2020-06-24","conditions":"Androgenetic Alopecia","enrollment":209},{"nctId":"NCT03467412","phase":"PHASE2","title":"To Investigate Efficacy of FOL-005 on Hair Growth on Scalp Skin","status":"COMPLETED","sponsor":"Follicum AB","startDate":"2018-02-27","conditions":"Androgenic Alopecia","enrollment":60},{"nctId":"NCT02793557","phase":"PHASE1, PHASE2","title":"Investigation of FOL-005 on Clinical Safety and Effect on Hair Growth","status":"COMPLETED","sponsor":"Follicum AB","startDate":"2016-01","conditions":"Hypertrichosis, Alopecia, Hirsutism","enrollment":44}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":3,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_2","status":"active","brandName":"FOL-005","genericName":"FOL-005","companyName":"Follicum AB","companyId":"follicum-ab","modality":"Small molecule","firstApprovalDate":"","aiSummary":"FOL-005 is a Wnt/β-catenin signaling activator designed to stimulate hair follicle growth and treat hair loss. Used for Androgenetic alopecia (male and female pattern hair loss).","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":1,"withResults":1},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}