{"id":"flutoprazepam","rwe":[{"pmid":"22258993","year":"2012","title":"Muscle relaxants for pain management in rheumatoid arthritis.","finding":"","journal":"The Cochrane database of systematic reviews","studyType":"Clinical Study"},{"pmid":"9742288","year":"1998","title":"Anticonvulsant properties of 1,4-benzodiazepine derivatives in amygdaloid-kindled seizures and their chemical structure-related anticonvulsant action.","finding":"","journal":"Pharmacology","studyType":"Clinical Study"},{"pmid":"1936062","year":"1991","title":"Propranolol does not alter flutoprazepam kinetics and metabolism in the rat.","finding":"","journal":"European journal of drug metabolism and pharmacokinetics","studyType":"Clinical Study"},{"pmid":"1974429","year":"1990","title":"Effect of flutoprazepam on skills essential for driving motor vehicles.","finding":"","journal":"Arzneimittel-Forschung","studyType":"Clinical Study"},{"pmid":"2633923","year":"1989","title":"Pharmacokinetics of flutoprazepam, a novel benzodiazepine drug, in normal subjects.","finding":"","journal":"European journal of drug metabolism and pharmacokinetics","studyType":"Clinical Study"}],"tags":[{"label":"flutoprazepam","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"},{"label":"Induction of general anesthesia","category":"indication"},{"label":"Insomnia","category":"indication"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"restas","offLabel":[],"synonyms":["restas","flutoprazepam"],"timeline":[],"approvals":[],"brandName":"Restas","ecosystem":[{"indication":"Induction of general anesthesia","otherDrugs":[],"globalPrevalence":null},{"indication":"Insomnia","otherDrugs":[{"name":"amobarbital","slug":"amobarbital","company":""},{"name":"choline","slug":"choline","company":""},{"name":"daridorexant","slug":"daridorexant","company":"Idorsia Pharmaceuticals Ltd"},{"name":"diphenhydramine","slug":"diphenhydramine","company":"Mcneil Cons"}],"globalPrevalence":750000000}],"mechanism":{"modality":"Small Molecule","drugClass":"flutoprazepam","explanation":"Imagine your brain is like a busy city with many people talking and moving around. GABA is like a quieting signal that helps slow down the activity in the city. Flutoprazepam increases the strength of this signal, making it easier for the brain to relax and fall asleep, or to induce general anesthesia.","oneSentence":"Flutoprazepam works by enhancing the activity of the neurotransmitter gamma-aminobutyric acid (GABA) in the brain.","technicalDetail":"Flutoprazepam acts as a benzodiazepine receptor agonist, specifically binding to the GABA_A receptor and enhancing the activity of GABA, a major inhibitory neurotransmitter in the brain."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/1226","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=FLUTOPRAZEPAM","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T11:34:30.639759","biosimilars":[],"competitors":[],"genericName":"flutoprazepam","indications":{"approved":[{"name":"Induction of general anesthesia","source":"DrugCentral","snomedId":241687005,"regulator":"FDA"},{"name":"Insomnia","source":"DrugCentral","snomedId":193462001,"regulator":"FDA","usPrevalence":70000000,"globalPrevalence":750000000,"prevalenceMethod":"curated","prevalenceSource":"Sleep Medicine Reviews, 2023"}],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"UNII":"2GHY1101MM","CHEBI":"CHEBI:31629","INN_ID":"5037","UMLSCUI":"C0117998","ChEMBL_ID":"CHEMBL2106743","KEGG_DRUG":"D01279","PUBCHEM_CID":"3400","MESH_SUPPLEMENTAL_RECORD_UI":"C029163"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":8,"therapeuticAreas":["Neuroscience"],"biosimilarFilings":[],"recentPublications":[{"date":"2012 Jan 18","pmid":"22258993","title":"Muscle relaxants for pain management in rheumatoid arthritis.","journal":"The Cochrane database of systematic reviews"},{"date":"1998 Nov","pmid":"9742288","title":"Anticonvulsant properties of 1,4-benzodiazepine derivatives in amygdaloid-kindled seizures and their chemical structure-related anticonvulsant action.","journal":"Pharmacology"},{"date":"1991 Jan-Mar","pmid":"1936062","title":"Propranolol does not alter flutoprazepam kinetics and metabolism in the rat.","journal":"European journal of drug metabolism and pharmacokinetics"},{"date":"1990 May","pmid":"1974429","title":"Effect of flutoprazepam on skills essential for driving motor vehicles.","journal":"Arzneimittel-Forschung"},{"date":"1989 Oct-Dec","pmid":"2633923","title":"Pharmacokinetics of flutoprazepam, a novel benzodiazepine drug, in normal subjects.","journal":"European journal of drug metabolism and pharmacokinetics"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Restas is a small molecule. It is also known by the synonyms Flutoprazepam and Restas.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":true,"safety":false,"trials":false,"score":2}}