{"id":"fluticasone-propionate-nasal-spray-loratadine","safety":{"commonSideEffects":[{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Epistaxis (nasal bleeding)"},{"rate":null,"effect":"Nasal irritation"},{"rate":null,"effect":"Somnolence"},{"rate":null,"effect":"Dry mouth"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Fluticasone propionate is a topical corticosteroid that inhibits inflammatory mediator release and reduces nasal mucosal inflammation. Loratadine is a selective H1-receptor antagonist that blocks histamine-induced allergic symptoms systemically. Together, they provide both local anti-inflammatory and systemic antihistamine effects for comprehensive allergy symptom control.","oneSentence":"This combination reduces allergic rhinitis symptoms by suppressing nasal inflammation via corticosteroid action and blocking histamine-mediated allergic responses via H1-receptor antagonism.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:46:52.309Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Allergic rhinitis (seasonal and perennial)"}]},"trialDetails":[{"nctId":"NCT03004131","phase":"PHASE4","title":"MP-AzeFlu Allergen Chamber - Onset of Action Study","status":"COMPLETED","sponsor":"MEDA Pharma GmbH & Co. KG","startDate":"2017-01-07","conditions":"Seasonal Allergic Rhinitis","enrollment":82},{"nctId":"NCT04179461","phase":"PHASE2","title":"Personalized Treatment Algorithms for Difficult-to-treat Asthma","status":"COMPLETED","sponsor":"Children's Hospital Medical Center, Cincinnati","startDate":"2018-03-16","conditions":"Asthma in Children","enrollment":21},{"nctId":"NCT03443843","phase":"PHASE4","title":"A Study to Evaluate Changes in Nasal Airflow of Loratadine/Pseudoephedrine Tablet and Fluticasone Propionate Nasal Spray in Subjects Following Allergen Exposure","status":"COMPLETED","sponsor":"Bayer","startDate":"2018-02-21","conditions":"Rhinitis, Allergic","enrollment":82},{"nctId":"NCT00562159","phase":"PHASE3","title":"Efficacy and Safety of Grass Sublingual Tablet in Adults (P05238 AM3)(COMPLETED)","status":"COMPLETED","sponsor":"ALK-Abelló A/S","startDate":"2007-11","conditions":"Rhinoconjunctivitis, Rhinitis, Conjunctivitis","enrollment":439},{"nctId":"NCT00550550","phase":"PHASE3","title":"Efficacy and Safety of Grass Sublingual Tablet in Children and Adolescents (P05239 AM3)(COMPLETED)","status":"COMPLETED","sponsor":"ALK-Abelló A/S","startDate":"2007-11","conditions":"Rhinoconjunctivitis, Rhinitis, Conjunctivitis","enrollment":345}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":17,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"fluticasone propionate nasal spray + loratadine","genericName":"fluticasone propionate nasal spray + loratadine","companyName":"MEDA Pharma GmbH & Co. KG","companyId":"meda-pharma-gmbh-co-kg","modality":"Small molecule","firstApprovalDate":"","aiSummary":"This combination reduces allergic rhinitis symptoms by suppressing nasal inflammation via corticosteroid action and blocking histamine-mediated allergic responses via H1-receptor antagonism. Used for Allergic rhinitis (seasonal and perennial).","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}