{"id":"fluticasone-propionate-0-05-lotion","safety":{"commonSideEffects":[{"rate":null,"effect":"Local skin irritation or burning"},{"rate":null,"effect":"Skin atrophy (with prolonged use)"},{"rate":null,"effect":"Folliculitis"},{"rate":null,"effect":"Hypopigmentation"},{"rate":null,"effect":"Systemic corticosteroid effects (rare with topical use)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Fluticasone propionate is a potent synthetic glucocorticoid that penetrates the skin and binds to intracellular glucocorticoid receptors, leading to decreased production of inflammatory mediators, reduced immune cell infiltration, and suppression of local inflammatory cascades. This results in reduced erythema, pruritus, and other signs of dermatological inflammation. The 0.05% lotion formulation provides topical delivery with minimal systemic absorption when applied to intact skin.","oneSentence":"Fluticasone propionate is a topical corticosteroid that suppresses local inflammatory and immune responses in the skin by binding to glucocorticoid receptors.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:46:46.730Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses"},{"name":"Atopic dermatitis"},{"name":"Contact dermatitis"},{"name":"Seborrheic dermatitis"}]},"trialDetails":[{"nctId":"NCT01915914","phase":"PHASE4","title":"A Randomized, Open-label, Comparative Study to Evaluate an Intermittent Dosing Regimen of Fluticasone Propionate 0.05% Cream (Twice Per Week) in Reducing the Risk of Relapse When Added to Regular Daily Moisturization Using PHYSIOGEL Lotion in Paediatric Subjects With Stabilized Atopic Dermatitis","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2013-12-23","conditions":"Skin Diseases","enrollment":107},{"nctId":"NCT00546000","phase":"PHASE4","title":"Cutivate Lotion HPA Axis Pediatric Study","status":"COMPLETED","sponsor":"Fougera Pharmaceuticals Inc.","startDate":"2007-07","conditions":"Atopic Dermatitis","enrollment":56}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Fluticasone propionate 0.05% lotion","genericName":"Fluticasone propionate 0.05% lotion","companyName":"Fougera Pharmaceuticals Inc.","companyId":"fougera-pharmaceuticals-inc","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Fluticasone propionate is a topical corticosteroid that suppresses local inflammatory and immune responses in the skin by binding to glucocorticoid receptors. Used for Inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses, Atopic dermatitis, Contact dermatitis.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}