{"id":"flurithromycin","rwe":[],"tags":[{"label":"flurithromycin","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"J01FA14","category":"atc"},{"label":"Active","category":"status"},{"label":"Enzyme Inhibitors","category":"pharmacology"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"8-fluoroerythromycin","offLabel":[],"synonyms":["flurithromycin","8-Fluoroerythromycin A","8-Fluoroerythromycin"],"timeline":[],"approvals":[],"brandName":"8-Fluoroerythromycin","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"flurithromycin","explanation":"Imagine your body's cells are like factories that make proteins to keep you healthy. Bacteria are like tiny factories that make proteins to harm you. Flurithromycin is a special tool that blocks the bacterial factories from making proteins, ultimately killing the bacteria and helping to fight off infections.","oneSentence":"Flurithromycin works by binding to the bacterial ribosome and inhibiting the action of the 50S subunit, thereby preventing the synthesis of essential bacterial proteins.","technicalDetail":"Flurithromycin binds to the 50S subunit of the bacterial ribosome, specifically to the 23S rRNA, and inhibits the action of the peptidyl transferase center, thereby preventing the formation of peptide bonds and the synthesis of essential bacterial proteins."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/1221","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=FLURITHROMYCIN","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T11:36:32.710921","_validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-20T08:49:19.169434+00:00","fieldsConflicting":0,"overallConfidence":0.95},"biosimilars":[],"competitors":[{"drugName":"erythromycin","drugSlug":"erythromycin","fdaApproval":"1964-06-24","genericCount":39,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"troleandomycin","drugSlug":"troleandomycin","fdaApproval":"1969-05-27","patentStatus":"Unknown","relationship":"same-class"},{"drugName":"clarithromycin","drugSlug":"clarithromycin","fdaApproval":"1991-10-31","genericCount":20,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"azithromycin","drugSlug":"azithromycin","fdaApproval":"1991-11-01","genericCount":31,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"dirithromycin","drugSlug":"dirithromycin","fdaApproval":"1995-06-19","patentStatus":"Unknown","relationship":"same-class"},{"drugName":"telithromycin","drugSlug":"telithromycin","fdaApproval":"2004-04-01","patentStatus":"Unknown","relationship":"same-class"}],"genericName":"flurithromycin","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"erythromycin","brandName":"erythromycin","genericName":"erythromycin","approvalYear":"1964","relationship":"same-class"},{"drugId":"troleandomycin","brandName":"troleandomycin","genericName":"troleandomycin","approvalYear":"1969","relationship":"same-class"},{"drugId":"clarithromycin","brandName":"clarithromycin","genericName":"clarithromycin","approvalYear":"1991","relationship":"same-class"},{"drugId":"azithromycin","brandName":"azithromycin","genericName":"azithromycin","approvalYear":"1991","relationship":"same-class"},{"drugId":"dirithromycin","brandName":"dirithromycin","genericName":"dirithromycin","approvalYear":"1995","relationship":"same-class"},{"drugId":"telithromycin","brandName":"telithromycin","genericName":"telithromycin","approvalYear":"2004","relationship":"same-class"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"UNII":"56C9DTE69V","CHEBI":"CHEBI:131719","INN_ID":"5534","UMLSCUI":"C0060591","ChEMBL_ID":"CHEMBL2106403","KEGG_DRUG":"D07242","DRUGBANK_ID":"DB13338","PUBCHEM_CID":"71260","MESH_SUPPLEMENTAL_RECORD_UI":"C045925"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":41,"therapeuticAreas":["Infectious Disease"],"atcClassification":{"source":"DrugCentral","atcCode":"J01FA14","allCodes":["J01FA14"]},"biosimilarFilings":[],"recentPublications":[],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"8-Fluoroerythromycin, also known as Flurithromycin, is a small molecule antibiotic belonging to the drug class of flurithromycin. Its exact target is unknown, but it is believed to work by inhibiting bacterial protein synthesis. Flurithromycin is not FDA-approved for any indications, and its commercial status is unclear. As a result, there is limited information available on its safety profile and pharmacokinetic properties. Further research is needed to fully understand the potential benefits and risks of this antibiotic.","enrichmentLevel":5,"visitCount":2,"trialStats":{"total":0,"withResults":0},"validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-20T08:49:19.169434+00:00","fieldsConflicting":0,"overallConfidence":0.95},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}