{"id":"fluprednidene-acetate","rwe":[{"pmid":"39613826","year":"2024","title":"Sex differences of fall-risk-increasing drugs in the middle-aged and elderly: a descriptive, cross-sectional study of FDA adverse event reporting system.","finding":"","journal":"Scientific reports","studyType":"Clinical Study"}],"tags":[{"label":"fluprednidene acetate","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"},{"label":"Glucocorticoids","category":"pharmacology"},{"label":"Hormones","category":"pharmacology"}],"phase":"unknown","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"emecort","offLabel":[],"synonyms":["fluprednidene acetate","corticoderm","decoderm","emecort","etacortin","Fluprednylidene 21-acetate","fluprednylidene acetate"],"timeline":[],"approvals":[],"brandName":"Emecort","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"fluprednidene acetate","explanation":"Imagine your body's immune system as a fire alarm that sounds when it detects an intruder. Emecort is like a fire alarm silencer that reduces the alarm's sensitivity, allowing the body to calm down and reduce inflammation. This helps to alleviate symptoms of conditions like arthritis or asthma.","oneSentence":"Emecort works by binding to glucocorticoid receptors in the body, triggering a cascade of anti-inflammatory effects.","technicalDetail":"Fluprednidene acetate exerts its effects by binding to the glucocorticoid receptor (GR), a transcription factor that regulates the expression of genes involved in inflammation and immune response. This binding event triggers a conformational change in the GR, allowing it to translocate to the nucleus and modulate the transcription of target genes, ultimately leading to the suppression of inflammatory responses."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/3238","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=fluprednidene acetate","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T11:33:38.638165","biosimilars":[],"competitors":[],"genericName":"fluprednidene acetate","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NDDF":"006528","UNII":"GE65DV564S","CHEBI":"CHEBI:135700","INN_ID":"2450","RXNORM":"236650","UMLSCUI":"C0060584","DRUGBANK_ID":"DB14634","PUBCHEM_CID":"9980241","SNOMEDCT_US":"414275002","MESH_SUPPLEMENTAL_RECORD_UI":"C100064"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":1,"therapeuticAreas":["Immunology"],"biosimilarFilings":[],"recentPublications":[{"date":"2024 Nov 29","pmid":"39613826","title":"Sex differences of fall-risk-increasing drugs in the middle-aged and elderly: a descriptive, cross-sectional study of FDA adverse event reporting system.","journal":"Scientific reports"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"unknown","modality":"Small Molecule","firstApprovalDate":"","aiSummary":"Emecort, also known as fluprednidene acetate, is a synthetic corticosteroid medication. It is a small molecule that works by mimicking the effects of cortisol in the body, reducing inflammation and suppressing the immune system. Emecort is used to treat various inflammatory conditions, but its specific indications are not well-documented. The commercial status of Emecort is unclear, and it may be patented or available as a generic medication. As a corticosteroid, Emecort carries key safety considerations, including potential side effects such as adrenal suppression and increased risk of infections.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}