{"id":"fluprednidene","rwe":[{"pmid":"39613826","year":"2024","title":"Sex differences of fall-risk-increasing drugs in the middle-aged and elderly: a descriptive, cross-sectional study of FDA adverse event reporting system.","finding":"","journal":"Scientific reports","studyType":"Clinical Study"},{"pmid":"7848344","year":"1994","title":"Dermal absorption of fluprednidene-21-acetate and miconazole from a new topical preparation in pigs.","finding":"","journal":"Arzneimittel-Forschung","studyType":"Clinical Study"},{"pmid":"1937890","year":"1991","title":"Comparison of dermal and systemic application of glucocorticoids on the RM 3/1+ macrophage in human blood.","finding":"","journal":"International archives of allergy and applied immunology","studyType":"Clinical Study"},{"pmid":"2683439","year":"1989","title":"[Optimized interval treatment of eczema with fluprednidene. A multicenter double-blind study].","finding":"","journal":"Zeitschrift fur Hautkrankheiten","studyType":"Clinical Study"},{"pmid":"2529150","year":"1989","title":"Steroid-induced dermal atrophy. Investigations on discontinuous application.","finding":"","journal":"Dermatologica","studyType":"Clinical Study"}],"tags":[{"label":"fluprednidene","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"D07AB07","category":"atc"},{"label":"Active","category":"status"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"fluprednylidene","offLabel":[],"synonyms":["fluprednidene","fluprednylidene"],"timeline":[],"approvals":[],"brandName":"Fluprednylidene","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"fluprednidene","explanation":"Imagine your body's immune system as a fire alarm that goes off when it senses danger. Fluprednylidene helps to turn down the volume on the fire alarm, so it doesn't sound as loudly and cause unnecessary inflammation. This can help to reduce swelling, pain, and other symptoms associated with conditions like arthritis or asthma.","oneSentence":"Fluprednylidene works by binding to the glucocorticoid receptor, which helps to reduce inflammation and modulate the immune system.","technicalDetail":"Fluprednylidene acts as a selective glucocorticoid receptor agonist, binding to the glucocorticoid receptor (GR) and inducing a conformational change that allows it to translocate to the nucleus, where it modulates the transcription of genes involved in inflammation and immune response."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/4553","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=FLUPREDNIDENE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T11:36:14.715905","biosimilars":[],"competitors":[{"drugName":"hydrocortisone butyrate","drugSlug":"hydrocortisone-butyrate","fdaApproval":"1982-03-31","genericCount":6,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"flumetasone","drugSlug":"flumetasone","fdaApproval":"","relationship":"same-class"},{"drugName":"fluorometholone","drugSlug":"fluorometholone","fdaApproval":"1972-01-12","genericCount":3,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"desonide","drugSlug":"desonide","fdaApproval":"1972-01-04","patentExpiry":"Aug 13, 2027","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"triamcinolone","drugSlug":"triamcinolone","fdaApproval":"1957-12-03","genericCount":9,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"alclometasone dipropionate","drugSlug":"alclometasone-dipropionate","fdaApproval":"1982-12-14","genericCount":3,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"hydrocortisone probutate","drugSlug":"hydrocortisone-probutate","fdaApproval":"1997-02-28","patentStatus":"Unknown","relationship":"same-class"},{"drugName":"dexamethasone","drugSlug":"dexamethasone","fdaApproval":"1958-10-30","patentExpiry":"Oct 7, 2036","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"clocortolone pivalate","drugSlug":"clocortolone-pivalate","fdaApproval":"1977-08-22","genericCount":1,"patentStatus":"Off-patent — generic available","relationship":"same-class"}],"genericName":"fluprednidene","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"hydrocortisone-butyrate","brandName":"hydrocortisone butyrate","genericName":"hydrocortisone butyrate","approvalYear":"1982","relationship":"same-class"},{"drugId":"flumetasone","brandName":"flumetasone","genericName":"flumetasone","approvalYear":"","relationship":"same-class"},{"drugId":"fluorometholone","brandName":"fluorometholone","genericName":"fluorometholone","approvalYear":"1972","relationship":"same-class"},{"drugId":"desonide","brandName":"desonide","genericName":"desonide","approvalYear":"1972","relationship":"same-class"},{"drugId":"triamcinolone","brandName":"triamcinolone","genericName":"triamcinolone","approvalYear":"1957","relationship":"same-class"},{"drugId":"alclometasone-dipropionate","brandName":"alclometasone dipropionate","genericName":"alclometasone dipropionate","approvalYear":"1982","relationship":"same-class"},{"drugId":"hydrocortisone-probutate","brandName":"hydrocortisone probutate","genericName":"hydrocortisone probutate","approvalYear":"1997","relationship":"same-class"},{"drugId":"dexamethasone","brandName":"dexamethasone","genericName":"dexamethasone","approvalYear":"1958","relationship":"same-class"},{"drugId":"clocortolone-pivalate","brandName":"clocortolone pivalate","genericName":"clocortolone pivalate","approvalYear":"1977","relationship":"same-class"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NDDF":"006528","UNII":"FA517NS3N7","CHEBI":"CHEBI:135989","INN_ID":"2450","RXNORM":"236650","UMLSCUI":"C0771950","ChEMBL_ID":"CHEMBL2106763","KEGG_DRUG":"D07201","DRUGBANK_ID":"DB08970","PUBCHEM_CID":"11794741","SNOMEDCT_US":"414275002"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":5,"therapeuticAreas":["Immunology"],"atcClassification":{"source":"DrugCentral","atcCode":"D07AB07","allCodes":["D07AB07","D07CB02","D07XB03"]},"biosimilarFilings":[],"recentPublications":[{"date":"2024 Nov 29","pmid":"39613826","title":"Sex differences of fall-risk-increasing drugs in the middle-aged and elderly: a descriptive, cross-sectional study of FDA adverse event reporting system.","journal":"Scientific reports"},{"date":"1994 Nov","pmid":"7848344","title":"Dermal absorption of fluprednidene-21-acetate and miconazole from a new topical preparation in pigs.","journal":"Arzneimittel-Forschung"},{"date":"1991","pmid":"1937890","title":"Comparison of dermal and systemic application of glucocorticoids on the RM 3/1+ macrophage in human blood.","journal":"International archives of allergy and applied immunology"},{"date":"1989 Sep 15","pmid":"2683439","title":"[Optimized interval treatment of eczema with fluprednidene. A multicenter double-blind study].","journal":"Zeitschrift fur Hautkrankheiten"},{"date":"1989","pmid":"2529150","title":"Steroid-induced dermal atrophy. Investigations on discontinuous application.","journal":"Dermatologica"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Fluprednylidene (FLUPREDNIDENE) is a small molecule drug in the fluprednidene class, but details about its target, FDA approval status, and commercial status are currently unknown. As a glucocorticoid receptor agonist, it is believed to work by binding to the glucocorticoid receptor, which then modulates the transcription of various genes involved in inflammation and immune response. The exact indications for fluprednylidene are unclear, but it is likely used to treat conditions characterized by inflammation or immune system dysregulation. Further research is needed to fully understand its pharmacological properties and clinical applications. Its safety profile and potential side effects are also unknown at this time.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}