{"id":"fluperolone","rwe":[{"pmid":"5523964","year":"1970","title":"[Results of use of 0.1 percent fluperolone ointment, Metral, in some allergic dermatoses].","finding":"","journal":"Vestnik dermatologii i venerologii","studyType":"Clinical Study"},{"pmid":"5496842","year":"1970","title":"[Experience in the use of 0.1 percent fluperolone ointment methral in various allergic dermatoses].","finding":"","journal":"Vestnik dermatologii i venerologii","studyType":"Clinical Study"},{"pmid":"4240801","year":"1967","title":"[On the topical use of a new steroid, fluperolone, in certain professional and non-professional dermatologic lesions].","finding":"","journal":"Minerva dermatologica","studyType":"Clinical Study"},{"pmid":"5613652","year":"1967","title":"[Fluperolone in allergic and ortho-ergic eczematous dermatoses].","finding":"","journal":"Minerva dermatologica","studyType":"Clinical Study"},{"pmid":"5991014","year":"1966","title":"[Fluperolone acetate for topical use in dermatology].","finding":"","journal":"Minerva dermatologica","studyType":"Clinical Study"}],"tags":[{"label":"Small Molecule","category":"modality"},{"label":"D07AB05","category":"atc"},{"label":"Active","category":"status"},{"label":"Glucocorticoids","category":"pharmacology"},{"label":"Hormones","category":"pharmacology"}],"phase":"unknown","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"methral","offLabel":[],"synonyms":["methral","fluperolone","alacortril","fluperolone acetate"],"timeline":[],"approvals":[],"brandName":"Methral","ecosystem":[],"mechanism":{"modality":"Small Molecule","explanation":"Imagine your body's cells have locks on them, and Methral is a key that fits into those locks. When it binds to the lock, it triggers a response that helps to treat a particular condition. This is a simplified explanation of how Methral works at a molecular level.","oneSentence":"Methral works by interacting with a specific biological target to produce a therapeutic effect.","technicalDetail":"Fluperolone is a synthetic corticosteroid with a complex mechanism of action involving the modulation of gene expression and cellular signaling pathways."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/3237","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=fluperolone","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T11:33:22.254896","biosimilars":[],"competitors":[{"drugName":"hydrocortisone butyrate","drugSlug":"hydrocortisone-butyrate","fdaApproval":"1982-03-31","genericCount":6,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"flumetasone","drugSlug":"flumetasone","fdaApproval":"","relationship":"same-class"},{"drugName":"fluorometholone","drugSlug":"fluorometholone","fdaApproval":"1972-01-12","genericCount":3,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"desonide","drugSlug":"desonide","fdaApproval":"1972-01-04","patentExpiry":"Aug 13, 2027","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"triamcinolone","drugSlug":"triamcinolone","fdaApproval":"1957-12-03","genericCount":9,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"alclometasone dipropionate","drugSlug":"alclometasone-dipropionate","fdaApproval":"1982-12-14","genericCount":3,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"hydrocortisone probutate","drugSlug":"hydrocortisone-probutate","fdaApproval":"1997-02-28","patentStatus":"Unknown","relationship":"same-class"},{"drugName":"dexamethasone","drugSlug":"dexamethasone","fdaApproval":"1958-10-30","patentExpiry":"Oct 7, 2036","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"clocortolone pivalate","drugSlug":"clocortolone-pivalate","fdaApproval":"1977-08-22","genericCount":1,"patentStatus":"Off-patent — generic available","relationship":"same-class"}],"genericName":"fluperolone","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"hydrocortisone-butyrate","brandName":"hydrocortisone butyrate","genericName":"hydrocortisone butyrate","approvalYear":"1982","relationship":"same-class"},{"drugId":"flumetasone","brandName":"flumetasone","genericName":"flumetasone","approvalYear":"","relationship":"same-class"},{"drugId":"fluorometholone","brandName":"fluorometholone","genericName":"fluorometholone","approvalYear":"1972","relationship":"same-class"},{"drugId":"desonide","brandName":"desonide","genericName":"desonide","approvalYear":"1972","relationship":"same-class"},{"drugId":"triamcinolone","brandName":"triamcinolone","genericName":"triamcinolone","approvalYear":"1957","relationship":"same-class"},{"drugId":"alclometasone-dipropionate","brandName":"alclometasone dipropionate","genericName":"alclometasone dipropionate","approvalYear":"1982","relationship":"same-class"},{"drugId":"hydrocortisone-probutate","brandName":"hydrocortisone probutate","genericName":"hydrocortisone probutate","approvalYear":"1997","relationship":"same-class"},{"drugId":"dexamethasone","brandName":"dexamethasone","genericName":"dexamethasone","approvalYear":"1958","relationship":"same-class"},{"drugId":"clocortolone-pivalate","brandName":"clocortolone pivalate","genericName":"clocortolone pivalate","approvalYear":"1977","relationship":"same-class"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"UNII":"S33056JLS5","CHEBI":"CHEBI:135705","INN_ID":"1473","UMLSCUI":"C3652595","ChEMBL_ID":"CHEMBL2107401","KEGG_DRUG":"D04225","DRUGBANK_ID":"DB13491","PUBCHEM_CID":"56841872","SECONDARY_CAS_RN":"3841-11-0","MESH_SUPPLEMENTAL_RECORD_UI":"C005017"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":11,"therapeuticAreas":["Other"],"atcClassification":{"source":"DrugCentral","atcCode":"D07AB05","allCodes":["D07AB05"]},"biosimilarFilings":[],"recentPublications":[{"date":"1970 Sep","pmid":"5523964","title":"[Results of use of 0.1 percent fluperolone ointment, Metral, in some allergic dermatoses].","journal":"Vestnik dermatologii i venerologii"},{"date":"1970 Jun","pmid":"5496842","title":"[Experience in the use of 0.1 percent fluperolone ointment methral in various allergic dermatoses].","journal":"Vestnik dermatologii i venerologii"},{"date":"1967 Sep","pmid":"4240801","title":"[On the topical use of a new steroid, fluperolone, in certain professional and non-professional dermatologic lesions].","journal":"Minerva dermatologica"},{"date":"1967 Apr","pmid":"5613652","title":"[Fluperolone in allergic and ortho-ergic eczematous dermatoses].","journal":"Minerva dermatologica"},{"date":"1966 Sep","pmid":"5991014","title":"[Fluperolone acetate for topical use in dermatology].","journal":"Minerva dermatologica"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"unknown","modality":"Small Molecule","firstApprovalDate":"","aiSummary":"Methral (fluperolone) is a small molecule drug with unknown target and drug class. Its commercial status is unclear, and it is not known whether it is FDA approved or off-patent. Methral is used to treat unknown indications, and its key safety considerations are also unknown. Further research is needed to understand its pharmacological properties and clinical applications.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}