{"id":"fluoxetine-valsartan","safety":{"commonSideEffects":[{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Hyperkalemia"},{"rate":null,"effect":"Diarrhea"},{"rate":null,"effect":"Insomnia"}]},"_chembl":{"chemblId":"CHEMBL1069","moleculeType":"Small molecule","molecularWeight":"435.53"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Fluoxetine inhibits serotonin reuptake in the central nervous system, treating depression and anxiety disorders. Valsartan blocks angiotensin II type 1 receptors in vascular smooth muscle and the adrenal gland, reducing blood pressure and providing cardiovascular protection. The combination addresses comorbid depression and hypertension in a single regimen.","oneSentence":"This combination pairs a selective serotonin reuptake inhibitor with an angiotensin II receptor blocker to address both mood and blood pressure regulation.","_ai_confidence":"low"},"_scrapedAt":"2026-03-27T23:30:36.158Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Depression with concurrent hypertension"},{"name":"Anxiety disorders with hypertension"}]},"trialDetails":[{"nctId":"NCT01699490","phase":"PHASE4","title":"Role of Inflammation Factors and Insulin Resistance in Major Depressive Disorder","status":"UNKNOWN","sponsor":"National Cheng-Kung University Hospital","startDate":"2012-08","conditions":"Major Depressive Disorder","enrollment":200}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":6,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Prozac","Diovan"],"phase":"marketed","status":"active","brandName":"Fluoxetine + Valsartan","genericName":"Fluoxetine + Valsartan","companyName":"National Cheng-Kung University Hospital","companyId":"national-cheng-kung-university-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"This combination pairs a selective serotonin reuptake inhibitor with an angiotensin II receptor blocker to address both mood and blood pressure regulation. Used for Depression with concurrent hypertension, Anxiety disorders with hypertension.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}