{"id":"fluorouracil-implant","safety":{"commonSideEffects":[{"rate":null,"effect":"Myelosuppression"},{"rate":null,"effect":"Gastrointestinal toxicity"},{"rate":null,"effect":"Hand-foot syndrome"},{"rate":null,"effect":"Mucositis"},{"rate":null,"effect":"Local tissue reaction at implant site"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Fluorouracil (5-FU) is a pyrimidine analog that inhibits thymidylate synthase, blocking dTMP synthesis and disrupting DNA replication in rapidly dividing cells. The implant formulation provides local or regional drug delivery to maximize tumor exposure while potentially reducing systemic toxicity. This approach is particularly relevant for colorectal and breast cancers where regional or local delivery can improve therapeutic efficacy.","oneSentence":"Fluorouracil implant delivers the chemotherapy agent 5-fluorouracil directly to tumor tissue to inhibit thymidylate synthase and disrupt DNA synthesis in cancer cells.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:13:00.134Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Colorectal cancer"},{"name":"Breast cancer"}]},"trialDetails":[{"nctId":"NCT05863195","phase":"PHASE3","title":"Testing Pump Chemotherapy in Addition to Standard of Care Chemotherapy Versus Standard of Care Chemotherapy Alone for Patients With Unresectable Colorectal Liver Metastases: The PUMP Trial","status":"RECRUITING","sponsor":"ECOG-ACRIN Cancer Research Group","startDate":"2023-10-19","conditions":"Metastatic Colorectal Carcinoma, Metastatic Malignant Neoplasm in the Liver, Stage IV Colorectal Cancer AJCC 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Used for Colorectal cancer, Breast cancer.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}