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This combination is a classic chemotherapy regimen used to enhance cytotoxic activity against rapidly dividing cancer cells.","oneSentence":"Fluorouracil inhibits thymidylate synthase to block DNA synthesis, while folinic acid enhances its cytotoxic effect by providing reduced folate cofactors.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:46:53.010Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Colorectal cancer"},{"name":"Gastric cancer"},{"name":"Breast cancer"},{"name":"Pancreatic cancer"}]},"trialDetails":[{"nctId":"NCT06948448","phase":"PHASE2","title":"A Study to Evaluate the Safety and Efficacy of Two Dose Levels of ONO-4578 With Opdivo®, in Combination With mFOLFOX6 and Bevacizumab Versus Standard of Care in Participants With Non-MSI-H/dMMR, PD-L1 Positive Advanced Colorectal Cancer","status":"RECRUITING","sponsor":"Ono Pharmaceutical Co. 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