{"id":"fluorometholone-0-1-oph-susp","safety":{"commonSideEffects":[{"rate":null,"effect":"Ocular irritation or discomfort"},{"rate":null,"effect":"Transient blurred vision"},{"rate":null,"effect":"Increased intraocular pressure (with prolonged use)"},{"rate":null,"effect":"Posterior subcapsular cataract formation (with chronic use)"},{"rate":null,"effect":"Secondary ocular infection"}]},"_chembl":{"chemblId":"CHEMBL1200600","moleculeType":"Small molecule","molecularWeight":"376.47"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Fluorometholone reduces inflammation by inhibiting the release of inflammatory mediators and suppressing immune cell activity in ocular tissues. It is a fluorinated corticosteroid with moderate potency, designed for topical ophthalmic use to minimize systemic absorption while maintaining local anti-inflammatory efficacy.","oneSentence":"Fluorometholone is a topical corticosteroid that suppresses inflammatory and immune responses in the eye by binding to glucocorticoid receptors.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:39:41.516Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Inflammatory and allergic conditions of the eye, including allergic conjunctivitis"},{"name":"Post-operative inflammation following ocular surgery"},{"name":"Steroid-responsive inflammatory conditions of the palpebral and bulbar conjunctiva, cornea, and anterior segment of the globe"}]},"trialDetails":[{"nctId":"NCT04149210","phase":"PHASE3","title":"FLuorometholone as Adjunctive MEdical Therapy for TT Surgery (FLAME) Trial","status":"COMPLETED","sponsor":"Massachusetts Eye and Ear Infirmary","startDate":"2021-08-19","conditions":"Trachomatous Trichiasis (TT), Eye Diseases, Eyelid Diseases","enrollment":2410},{"nctId":"NCT05716945","phase":"PHASE4","title":"The OPTIMISE Study","status":"RECRUITING","sponsor":"Maastricht University Medical Center","startDate":"2024-07-29","conditions":"Pseudophakic Bullous Keratopathy, Fuchs' Endothelial Dystrophy, Intraocular Pressure","enrollment":342},{"nctId":"NCT03123614","phase":"PHASE4","title":"Loteprednol vs. Prednisolone and Fluorometholone","status":"COMPLETED","sponsor":"University of Utah","startDate":"2014-09-19","conditions":"Intraocular Pressure, Corneal Opacity","enrollment":131}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["FML"],"phase":"marketed","status":"active","brandName":"Fluorometholone 0.1% Oph Susp","genericName":"Fluorometholone 0.1% Oph Susp","companyName":"Maastricht University Medical Center","companyId":"maastricht-university-medical-center","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Fluorometholone is a topical corticosteroid that suppresses inflammatory and immune responses in the eye by binding to glucocorticoid receptors. Used for Inflammatory and allergic conditions of the eye, including allergic conjunctivitis, Post-operative inflammation following ocular surgery, Steroid-responsive inflammatory conditions of the palpebral and bulbar conjunctiva, cornea, and anterior segment of the globe.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":1},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}