{"id":"fluoromethalone-01","safety":{"commonSideEffects":[{"rate":null,"effect":"Elevated intraocular pressure"},{"rate":null,"effect":"Posterior subcapsular cataract formation"},{"rate":null,"effect":"Secondary ocular infection"},{"rate":null,"effect":"Ocular irritation or discomfort"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"As a fluorinated corticosteroid, fluoromethalone penetrates ocular tissues and activates intracellular glucocorticoid receptors, leading to decreased production of inflammatory mediators, reduced leukocyte infiltration, and suppression of immune cell activation. This results in reduced inflammation, edema, and discomfort in ocular inflammatory conditions.","oneSentence":"Fluoromethalone is a topical corticosteroid that suppresses inflammatory and immune responses in the eye by binding to glucocorticoid receptors.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:30:39.643Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Inflammatory and allergic conditions of the palpebral and bulbar conjunctiva, lid, and anterior segment of the eye"},{"name":"Post-operative inflammation following ocular surgery"},{"name":"Corneal injury from chemical, radiation, or thermal burns"}]},"trialDetails":[{"nctId":"NCT04839549","phase":"PHASE4","title":"Efficacy and Safety of Dextenza Compared to Topical Fluorometholone in Patients With Ocular Rosacea","status":"WITHDRAWN","sponsor":"Eye Associates of Central Texas","startDate":"2020-06-06","conditions":"Ocular Rosacea","enrollment":""}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":38,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Fluoromethalone .01%","genericName":"Fluoromethalone .01%","companyName":"Eye Associates of Central Texas","companyId":"eye-associates-of-central-texas","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Fluoromethalone is a topical corticosteroid that suppresses inflammatory and immune responses in the eye by binding to glucocorticoid receptors. Used for Inflammatory and allergic conditions of the palpebral and bulbar conjunctiva, lid, and anterior segment of the eye, Post-operative inflammation following ocular surgery, Corneal injury from chemical, radiation, or thermal burns.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}