{"id":"fluocortolone","rwe":[],"tags":[{"label":"fluocortolone","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"C05AA08","category":"atc"},{"label":"Active","category":"status"},{"label":"Anti-Inflammatory Agents","category":"pharmacology"},{"label":"Glucocorticoids","category":"pharmacology"},{"label":"Hormones","category":"pharmacology"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"flucortolone","offLabel":[],"synonyms":["fluocortolone","flucortolone","fluocortolon"],"timeline":[],"approvals":[],"brandName":"Flucortolone","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"fluocortolone","explanation":"Imagine your body's immune system as a fire alarm that sounds when it detects something foreign. Flucortolone helps to turn down the volume on the fire alarm, reducing the inflammation and immune response that can cause harm. This allows the body to heal and recover from injuries or infections.","oneSentence":"Flucortolone works by binding to glucocorticoid receptors in the body, which helps to reduce inflammation and suppress the immune system.","technicalDetail":"Flucortolone exerts its effects by binding to the glucocorticoid receptor (GR), a transcription factor that regulates the expression of genes involved in inflammation and immune response. This binding leads to the repression of pro-inflammatory genes and the induction of anti-inflammatory genes, resulting in a decrease in the production of pro-inflammatory cytokines and mediators."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/1206","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=FLUOCORTOLONE","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=FLUOCORTOLONE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T11:34:09.623289","biosimilars":[],"competitors":[{"drugName":"hydrocortisone","drugSlug":"hydrocortisone","fdaApproval":"1952-08-05","patentExpiry":"Nov 19, 2032","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"prednisolone","drugSlug":"prednisolone","fdaApproval":"1955-06-21","genericCount":42,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"betamethasone","drugSlug":"betamethasone","fdaApproval":"1961-04-17","patentStatus":"Unknown","relationship":"same-class"},{"drugName":"fluorometholone","drugSlug":"fluorometholone","fdaApproval":"1972-01-12","genericCount":3,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"dexamethasone","drugSlug":"dexamethasone","fdaApproval":"1958-10-30","patentExpiry":"Oct 7, 2036","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"fluocinolone acetonide","drugSlug":"fluocinolone-acetonide","fdaApproval":"1963-02-15","patentExpiry":"Nov 7, 2028","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"fluocinonide","drugSlug":"fluocinonide","fdaApproval":"1971-06-30","genericCount":23,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"triamcinolone","drugSlug":"triamcinolone","fdaApproval":"1957-12-03","genericCount":9,"patentStatus":"Off-patent — generic available","relationship":"same-class"}],"genericName":"fluocortolone","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"hydrocortisone","brandName":"hydrocortisone","genericName":"hydrocortisone","approvalYear":"1952","relationship":"same-class"},{"drugId":"prednisolone","brandName":"prednisolone","genericName":"prednisolone","approvalYear":"1955","relationship":"same-class"},{"drugId":"betamethasone","brandName":"betamethasone","genericName":"betamethasone","approvalYear":"1961","relationship":"same-class"},{"drugId":"fluorometholone","brandName":"fluorometholone","genericName":"fluorometholone","approvalYear":"1972","relationship":"same-class"},{"drugId":"dexamethasone","brandName":"dexamethasone","genericName":"dexamethasone","approvalYear":"1958","relationship":"same-class"},{"drugId":"fluocinolone-acetonide","brandName":"fluocinolone acetonide","genericName":"fluocinolone acetonide","approvalYear":"1963","relationship":"same-class"},{"drugId":"fluocinonide","brandName":"fluocinonide","genericName":"fluocinonide","approvalYear":"1971","relationship":"same-class"},{"drugId":"triamcinolone","brandName":"triamcinolone","genericName":"triamcinolone","approvalYear":"1957","relationship":"same-class"}],"trialDetails":[{"nctId":"NCT03757078","phase":"","title":"Study to Find Out How Symptoms Severity Changes During the Standard Course of Treatment With the Cream Relief Pro and Suppositories Relief Pro (Active Ingredients Are Fluocortolone + Lidocaine) in Patients Suffering From Twisted and Bulging Veins in the Rectal Area (Acute Hemorrhoids)","status":"COMPLETED","sponsor":"Bayer","startDate":"2018-11-30","conditions":["Acute Hemorrhoids"],"enrollment":1000,"completionDate":"2019-10-20"}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NUI":"N0000008063","NDDF":"003731","UNII":"65VXC1MH0J","CHEBI":"CHEBI:135581","INN_ID":"1904","RXNORM":"4463","UMLSCUI":"C0016301","ChEMBL_ID":"CHEMBL251634","KEGG_DRUG":"D04218","DRUGBANK_ID":"DB08971","PUBCHEM_CID":"9053","SNOMEDCT_US":"116590000","MESH_DESCRIPTOR_UI":"D005448"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"pharmacokinetics":{"source":"DrugCentral","halfLife":"1.3 hours","clearance":"7.0 mL/min/kg","bioavailability":"90%","fractionUnbound":"0.04%","volumeOfDistribution":"0.68 L/kg"},"publicationCount":109,"therapeuticAreas":["Immunology"],"atcClassification":{"source":"DrugCentral","atcCode":"C05AA08","allCodes":["C05AA08","D07AC05","D07BC03","D07CC06","D07XC05","H02AB03","S01CA04"]},"biosimilarFilings":[],"recentPublications":[],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Flucortolone is a small molecule corticosteroid drug of the fluocortolone class. Its mechanism of action involves binding to glucocorticoid receptors, leading to anti-inflammatory and immunosuppressive effects. However, due to limited information, its target and approved indications are unknown. The commercial status of flucortolone is also unclear, with no information available on its patent status or generic manufacturers. Further research is needed to fully understand its clinical applications and safety profile.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":true,"score":2}}