{"id":"fluocortin-butyl","rwe":[{"pmid":"11928263","year":"2002","title":"[Steroid sprays in non-infectious rhinitis and sinusitis. Proper and regular spraying does not damage the nasal mucosa].","finding":"","journal":"MMW Fortschritte der Medizin","studyType":"Clinical Study"},{"pmid":"10782521","year":"2000","title":"Glucocorticosteroids rapidly inhibit allergen-induced expression of E-selectin in vitro in a mucosal model of allergic rhinitis.","finding":"","journal":"Allergy","studyType":"Clinical Study"},{"pmid":"8850046","year":"1996","title":"Double-blind study of prednicarbate versus fluocortin butyl ester in atopic dermatitis.","finding":"","journal":"International journal of dermatology","studyType":"Clinical Study"},{"pmid":"1880325","year":"1991","title":"Intranasal fluocortin butyl in patients with perennial rhinitis: a 12-month efficacy and safety study including nasal biopsy.","finding":"","journal":"The Journal of allergy and clinical immunology","studyType":"Clinical Study"},{"pmid":"2140759","year":"1990","title":"Allergic contact dermatitis from fluocortin butyl.","finding":"","journal":"Contact dermatitis","studyType":"Clinical Study"}],"tags":[{"label":"fluocortin butyl","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"D07AB04","category":"atc"},{"label":"Active","category":"status"},{"label":"Dermatologic Agents","category":"pharmacology"},{"label":"Glucocorticoids","category":"pharmacology"},{"label":"Hormones","category":"pharmacology"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"vaspit","offLabel":[],"synonyms":["fluocortin butyl","fluocortin butyl ester","varlane","vaspit"],"timeline":[],"approvals":[],"brandName":"Vaspit","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"fluocortin butyl","explanation":"Think of it like a key fitting into a lock. Vaspit is the key, and the glucocorticoid receptor is the lock. When Vaspit binds to the receptor, it triggers a response that helps to reduce inflammation and suppress the immune system.","oneSentence":"Vaspit works by binding to glucocorticoid receptors in the body, mimicking the effects of cortisol.","technicalDetail":"Fluocortin butyl exerts its effects by binding to the glucocorticoid receptor (GR), a transcription factor that regulates the expression of genes involved in inflammation and immune response. This binding causes a conformational change in the GR, which then translocates to the nucleus and regulates the transcription of target genes, leading to anti-inflammatory and immunosuppressive effects."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/3234","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=FLUOCORTIN BUTYL","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T11:31:50.989169","biosimilars":[],"competitors":[{"drugName":"hydrocortisone butyrate","drugSlug":"hydrocortisone-butyrate","fdaApproval":"1982-03-31","genericCount":6,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"flumetasone","drugSlug":"flumetasone","fdaApproval":"","relationship":"same-class"},{"drugName":"fluorometholone","drugSlug":"fluorometholone","fdaApproval":"1972-01-12","genericCount":3,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"desonide","drugSlug":"desonide","fdaApproval":"1972-01-04","patentExpiry":"Aug 13, 2027","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"triamcinolone","drugSlug":"triamcinolone","fdaApproval":"1957-12-03","genericCount":9,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"alclometasone dipropionate","drugSlug":"alclometasone-dipropionate","fdaApproval":"1982-12-14","genericCount":3,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"hydrocortisone probutate","drugSlug":"hydrocortisone-probutate","fdaApproval":"1997-02-28","patentStatus":"Unknown","relationship":"same-class"},{"drugName":"dexamethasone","drugSlug":"dexamethasone","fdaApproval":"1958-10-30","patentExpiry":"Oct 7, 2036","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"clocortolone pivalate","drugSlug":"clocortolone-pivalate","fdaApproval":"1977-08-22","genericCount":1,"patentStatus":"Off-patent — generic available","relationship":"same-class"}],"genericName":"fluocortin butyl","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"hydrocortisone-butyrate","brandName":"hydrocortisone butyrate","genericName":"hydrocortisone butyrate","approvalYear":"1982","relationship":"same-class"},{"drugId":"flumetasone","brandName":"flumetasone","genericName":"flumetasone","approvalYear":"","relationship":"same-class"},{"drugId":"fluorometholone","brandName":"fluorometholone","genericName":"fluorometholone","approvalYear":"1972","relationship":"same-class"},{"drugId":"desonide","brandName":"desonide","genericName":"desonide","approvalYear":"1972","relationship":"same-class"},{"drugId":"triamcinolone","brandName":"triamcinolone","genericName":"triamcinolone","approvalYear":"1957","relationship":"same-class"},{"drugId":"alclometasone-dipropionate","brandName":"alclometasone dipropionate","genericName":"alclometasone dipropionate","approvalYear":"1982","relationship":"same-class"},{"drugId":"hydrocortisone-probutate","brandName":"hydrocortisone probutate","genericName":"hydrocortisone probutate","approvalYear":"1997","relationship":"same-class"},{"drugId":"dexamethasone","brandName":"dexamethasone","genericName":"dexamethasone","approvalYear":"1958","relationship":"same-class"},{"drugId":"clocortolone-pivalate","brandName":"clocortolone pivalate","genericName":"clocortolone pivalate","approvalYear":"1977","relationship":"same-class"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NDDF":"006737","UNII":"6N7OA9MO7O","CHEBI":"CHEBI:135728","INN_ID":"3535","RXNORM":"25127","UMLSCUI":"C0060508","ChEMBL_ID":"CHEMBL2105087","KEGG_DRUG":"D04217","DRUGBANK_ID":"DB13223","PUBCHEM_CID":"15942715","SNOMEDCT_US":"717190006","SECONDARY_CAS_RN":"33124-50-4","MESH_SUPPLEMENTAL_RECORD_UI":"C011824"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":17,"therapeuticAreas":["Immunology"],"atcClassification":{"source":"DrugCentral","atcCode":"D07AB04","allCodes":["D07AB04"]},"biosimilarFilings":[],"recentPublications":[{"date":"2002 Mar 7","pmid":"11928263","title":"[Steroid sprays in non-infectious rhinitis and sinusitis. Proper and regular spraying does not damage the nasal mucosa].","journal":"MMW Fortschritte der Medizin"},{"date":"2000 Apr","pmid":"10782521","title":"Glucocorticosteroids rapidly inhibit allergen-induced expression of E-selectin in vitro in a mucosal model of allergic rhinitis.","journal":"Allergy"},{"date":"1996 Feb","pmid":"8850046","title":"Double-blind study of prednicarbate versus fluocortin butyl ester in atopic dermatitis.","journal":"International journal of dermatology"},{"date":"1991 Aug","pmid":"1880325","title":"Intranasal fluocortin butyl in patients with perennial rhinitis: a 12-month efficacy and safety study including nasal biopsy.","journal":"The Journal of allergy and clinical immunology"},{"date":"1990 Apr","pmid":"2140759","title":"Allergic contact dermatitis from fluocortin butyl.","journal":"Contact dermatitis"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Vaspit, also known as fluocortin butyl, is a small molecule drug of the corticosteroid class. Its exact target and mechanism of action are unknown, but it is believed to work by mimicking the effects of cortisol in the body. Vaspit is not FDA-approved for any indications, and its commercial status, patent status, and availability of generic manufacturers are also unknown. Further research is needed to determine its safety and efficacy. As a result, key safety considerations and potential side effects are currently unclear.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}