{"id":"fluocinonide-cream-0-1","safety":{"commonSideEffects":[{"rate":null,"effect":"Skin atrophy"},{"rate":null,"effect":"Striae"},{"rate":null,"effect":"Telangiectasia"},{"rate":null,"effect":"Local irritation or burning"},{"rate":null,"effect":"Systemic corticosteroid absorption (with prolonged use or occlusion)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Fluocinonide works by penetrating the skin and binding to intracellular glucocorticoid receptors, which then translocate to the nucleus and modulate gene expression. This leads to decreased production of inflammatory mediators, reduced vasodilation, and suppression of immune cell infiltration. The result is reduced erythema, pruritus, and other signs of cutaneous inflammation.","oneSentence":"Fluocinonide is a potent topical corticosteroid that suppresses inflammatory and immune responses in the skin by binding to glucocorticoid receptors.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:46:41.733Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Inflammatory and pruritic dermatoses responsive to topical corticosteroids (e.g., eczema, psoriasis, lichen planus, contact dermatitis)"}]},"trialDetails":[{"nctId":"NCT02301494","phase":"NA","title":"Effectiveness of Imiquimod Topical Cream in Early Stage Cutaneous T-cell Lymphoma","status":"WITHDRAWN","sponsor":"Rochester General Hospital","startDate":"2020-04","conditions":"Mycosis Fungoides","enrollment":""},{"nctId":"NCT01469767","phase":"PHASE2","title":"Efficacy of Fluocinonide Cream 0.1% (Vanos(R)) in Reducing Itch in Subjects With Atopic Dermatitis","status":"COMPLETED","sponsor":"Wake Forest University","startDate":"2012-02-01","conditions":"Atopic Dermatitis","enrollment":10},{"nctId":"NCT01049243","phase":"PHASE4","title":"A Study Evaluating the Efficacy of Fluocinonide Cream 0.1% (Vanos) in Subjects With Atopic Dermatitis","status":"COMPLETED","sponsor":"Wake Forest University Health Sciences","startDate":"2009-03","conditions":"Atopic Dermatitis","enrollment":20},{"nctId":"NCT00819507","phase":"PHASE4","title":"VANOS Cream and Skin Barrier Function","status":"COMPLETED","sponsor":"Oregon Health and Science University","startDate":"2009-01","conditions":"Atopic Dermatitis","enrollment":25},{"nctId":"NCT00667589","phase":"PHASE2","title":"Sorafenib-induced Hand- Foot Skin Reaction Treatment","status":"TERMINATED","sponsor":"Northwestern University","startDate":"2008-06","conditions":"Hand-foot Skin Reaction, Rash","enrollment":6}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":4,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Vanos"],"phase":"marketed","status":"active","brandName":"Fluocinonide Cream 0.1%","genericName":"Fluocinonide Cream 0.1%","companyName":"Wake Forest University Health Sciences","companyId":"wake-forest-university-health-sciences","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Fluocinonide is a potent topical corticosteroid that suppresses inflammatory and immune responses in the skin by binding to glucocorticoid receptors. Used for Inflammatory and pruritic dermatoses responsive to topical corticosteroids (e.g., eczema, psoriasis, lichen planus, contact dermatitis).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}