{"id":"fluocinolone-acetonide-intraocular-implant","safety":{"commonSideEffects":[{"rate":null,"effect":"Cataract formation or progression"},{"rate":null,"effect":"Elevated intraocular pressure / glaucoma"},{"rate":null,"effect":"Endophthalmitis"},{"rate":null,"effect":"Vitreous hemorrhage"},{"rate":null,"effect":"Retinal detachment"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"The intraocular implant provides sustained, localized release of fluocinolone acetonide, a potent glucocorticoid, directly to ocular tissues. This reduces inflammation, edema, and immune cell infiltration in the posterior segment of the eye. The implant formulation allows for prolonged therapeutic effect while minimizing systemic exposure.","oneSentence":"Fluocinolone acetonide is a corticosteroid that suppresses inflammatory and immune responses in the eye when delivered directly via intraocular implant.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:46:36.363Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Chronic diabetic macular edema"},{"name":"Uveitis affecting the posterior segment of the eye"},{"name":"Macular edema associated with retinal vein occlusion"}]},"trialDetails":[{"nctId":"NCT05486468","phase":"PHASE3","title":"The Use of Two YUTIQ Versus Sham for Treatment of Chronic Non Infectious Intraocular Inflammation Affecting the Posterior Segment","status":"RECRUITING","sponsor":"Texas Retina Associates","startDate":"2022-10-05","conditions":"Uveitis, Uveitis, Posterior, Uveitis, Anterior","enrollment":30},{"nctId":"NCT05322070","phase":"PHASE4","title":"Fluocinolone Acetonide Intravitreal Implant 0.18 mg in the Treatment of Chronic Non-Infectious Posterior Segment Uveitis","status":"ACTIVE_NOT_RECRUITING","sponsor":"Alimera Sciences","startDate":"2022-06-06","conditions":"Uveitis, Posterior","enrollment":125},{"nctId":"NCT00132691","phase":"PHASE4","title":"Multicenter Uveitis Steroid Treatment (MUST) Trial","status":"COMPLETED","sponsor":"JHSPH Center for Clinical Trials","startDate":"2005-09","conditions":"Uveitis","enrollment":255},{"nctId":"NCT00570830","phase":"NA","title":"Retisert and Cataract Surgery in Patients With Severe Uveitis","status":"COMPLETED","sponsor":"Duke University","startDate":"2006-09","conditions":"Intermediate Uveitis, Posterior Uveitis","enrollment":21}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":3,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["NDC 24208-416-01"],"phase":"marketed","status":"active","brandName":"fluocinolone acetonide intraocular implant","genericName":"fluocinolone acetonide intraocular implant","companyName":"JHSPH Center for Clinical Trials","companyId":"jhsph-center-for-clinical-trials","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Fluocinolone acetonide is a corticosteroid that suppresses inflammatory and immune responses in the eye when delivered directly via intraocular implant. Used for Chronic diabetic macular edema, Uveitis affecting the posterior segment of the eye, Macular edema associated with retinal vein occlusion.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}