{"id":"flunoxaprofen","rwe":[],"tags":[{"label":"flunoxaprofen","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"M01AE15","category":"atc"},{"label":"Active","category":"status"},{"label":"Rheumatoid arthritis","category":"indication"},{"label":"Analgesics","category":"pharmacology"},{"label":"Analgesics, Non-Narcotic","category":"pharmacology"},{"label":"Anti-Inflammatory Agents","category":"pharmacology"},{"label":"Anti-Inflammatory Agents, Non-Steroidal","category":"pharmacology"},{"label":"Antirheumatic Agents","category":"pharmacology"},{"label":"Peripheral Nervous System Agents","category":"pharmacology"},{"label":"Sensory System Agents","category":"pharmacology"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"(s)-flunoxaprofen","offLabel":[],"synonyms":["flunoxaprofen","(S)-(+)-Flunoxaprofen","(S)-Flunoxaprofen"],"timeline":[],"approvals":[],"brandName":"(S)-Flunoxaprofen","ecosystem":[{"indication":"Rheumatoid arthritis","otherDrugs":[{"name":"abatacept","slug":"abatacept","company":"Bristol Myers Squibb"},{"name":"aceclofenac","slug":"aceclofenac","company":""},{"name":"acetylsalicylic acid","slug":"acetylsalicylic-acid","company":"Endo Pharms"},{"name":"adalimumab","slug":"adalimumab","company":"Abbvie Inc"}],"globalPrevalence":18000000}],"mechanism":{"modality":"Small Molecule","drugClass":"flunoxaprofen","explanation":"Imagine your body's pain and inflammation response like a fire. Prostaglandins are like the fuel that keeps the fire burning. Flunoxaprofen is thought to work by reducing the amount of fuel available, thereby reducing the pain and inflammation.","oneSentence":"Flunoxaprofen is thought to work by inhibiting the production of prostaglandins, which are hormone-like substances that cause pain and inflammation.","technicalDetail":"Flunoxaprofen is believed to exert its effects through the inhibition of cyclooxygenase enzymes, specifically COX-1 and COX-2, which are responsible for the conversion of arachidonic acid to prostaglandins."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/1203","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=FLUNOXAPROFEN","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T11:33:49.387419","_validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-20T11:15:15.904747+00:00","fieldsConflicting":0,"overallConfidence":0.95},"biosimilars":[],"competitors":[{"drugName":"ibuprofen","drugSlug":"ibuprofen","fdaApproval":"1974-09-19","patentExpiry":"Sep 30, 2029","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"naproxen","drugSlug":"naproxen","fdaApproval":"1976-03-11","genericCount":31,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"ketoprofen","drugSlug":"ketoprofen","fdaApproval":"1986-01-09","genericCount":7,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"fenoprofen","drugSlug":"fenoprofen","fdaApproval":"1976-03-16","genericCount":16,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"benoxaprofen","drugSlug":"benoxaprofen","fdaApproval":"1982-04-19","relationship":"same-class"},{"drugName":"suprofen","drugSlug":"suprofen","fdaApproval":"1988-12-23","patentStatus":"Unknown","relationship":"same-class"},{"drugName":"flurbiprofen","drugSlug":"flurbiprofen","fdaApproval":"1986-12-31","genericCount":8,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"oxaprozin","drugSlug":"oxaprozin","fdaApproval":"1992-10-29","genericCount":13,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"esomeprazole","drugSlug":"esomeprazole","fdaApproval":"2001-02-20","patentExpiry":"Dec 8, 2036","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"misoprostol","drugSlug":"misoprostol","fdaApproval":"1988-12-27","genericCount":4,"patentStatus":"Off-patent — generic available","relationship":"same-class"}],"genericName":"flunoxaprofen","indications":{"approved":[{"name":"Rheumatoid arthritis","source":"DrugCentral","snomedId":69896004,"regulator":"FDA","usPrevalence":1500000,"globalPrevalence":18000000,"prevalenceMethod":"curated","prevalenceSource":"Lancet Rheumatology, 2023"}],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"ibuprofen","brandName":"ibuprofen","genericName":"ibuprofen","approvalYear":"1974","relationship":"same-class"},{"drugId":"naproxen","brandName":"naproxen","genericName":"naproxen","approvalYear":"1976","relationship":"same-class"},{"drugId":"ketoprofen","brandName":"ketoprofen","genericName":"ketoprofen","approvalYear":"1986","relationship":"same-class"},{"drugId":"fenoprofen","brandName":"fenoprofen","genericName":"fenoprofen","approvalYear":"1976","relationship":"same-class"},{"drugId":"benoxaprofen","brandName":"benoxaprofen","genericName":"benoxaprofen","approvalYear":"1982","relationship":"same-class"},{"drugId":"suprofen","brandName":"suprofen","genericName":"suprofen","approvalYear":"1988","relationship":"same-class"},{"drugId":"flurbiprofen","brandName":"flurbiprofen","genericName":"flurbiprofen","approvalYear":"1986","relationship":"same-class"},{"drugId":"oxaprozin","brandName":"oxaprozin","genericName":"oxaprozin","approvalYear":"1992","relationship":"same-class"},{"drugId":"esomeprazole","brandName":"esomeprazole","genericName":"esomeprazole","approvalYear":"2001","relationship":"same-class"},{"drugId":"misoprostol","brandName":"misoprostol","genericName":"misoprostol","approvalYear":"1988","relationship":"same-class"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"UNII":"UKU5U19W9M","CHEBI":"CHEBI:76154","INN_ID":"4870","UMLSCUI":"C0060504","ChEMBL_ID":"CHEMBL1614641","KEGG_DRUG":"D07219","DRUGBANK_ID":"DB13317","PUBCHEM_CID":"68869","MESH_SUPPLEMENTAL_RECORD_UI":"C045356"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":41,"therapeuticAreas":["Immunology"],"atcClassification":{"source":"DrugCentral","atcCode":"M01AE15","allCodes":["G02CC04","M01AE15"]},"biosimilarFilings":[],"recentPublications":[],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Flunoxaprofen is a small molecule drug in the flunoxaprofen class, originally developed by an unknown entity and currently owned by an unknown entity. It is used to treat rheumatoid arthritis, but its exact mechanism of action is unknown. The commercial status of flunoxaprofen is unclear, as it is unknown whether it is patented or available as a generic medication. Further research is needed to determine its key safety considerations and pharmacokinetic properties. As a result, its use should be approached with caution.","enrichmentLevel":5,"visitCount":1,"trialStats":{"total":0,"withResults":0},"validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-20T11:15:15.904747+00:00","fieldsConflicting":0,"overallConfidence":0.95},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":true,"safety":false,"trials":false,"score":2}}