{"id":"flumethiazide","rwe":[{"pmid":"6394743","year":"1984","title":"Mechanism for the high bias in the USP colorimetric assay for diazotizable substances in hydrochlorothiazide.","finding":"","journal":"Journal of pharmaceutical sciences","studyType":"Clinical Study"},{"pmid":"13963793","year":"1963","title":"Effects of flumethiazide, hydrochlorothiazide and acetazolamide on the intraocular pressure of rabbits receiving fludrocortisone.","finding":"","journal":"American journal of ophthalmology","studyType":"Clinical Study"},{"pmid":"13698488","year":"1961","title":"Effects of flumethiazide therapy on serum electrolyte levels.","finding":"","journal":"New York state journal of medicine","studyType":"Clinical Study"},{"pmid":"13700111","year":"1961","title":"Clinical experience with Rauwolfia-flumethiazide (Rautrax) in the treatment of arterial hypertension.","finding":"","journal":"The Journal of the Louisiana State Medical Society : official organ of the Louisiana State Medical Society","studyType":"Clinical Study"},{"pmid":"13717062","year":"1960","title":"Treatment of hypertension with Rauwolfia and flumethiazide.","finding":"","journal":"Pennsylvania medical journal (1928)","studyType":"Clinical Study"}],"tags":[{"label":"flumethiazide","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"},{"label":"Edema","category":"indication"},{"label":"Hypertensive disorder","category":"indication"}],"phase":"phase_2","safety":{"contraindications":["Acute nephropathy","Acute pancreatitis","Anaphylaxis","Anuria","Bronchospasm","Calculus in biliary tract","Cardiogenic shock","Chronic disease of respiratory system","Chronic heart failure","Complete atrioventricular block","Conduction disorder of the heart","Decompensated cardiac failure","Depressive disorder","Diabetes mellitus","Disease of liver","Electroconvulsive therapy","Epilepsy","Gout","Hepatic coma","Hypercalcemia","Hypercholesterolemia","Hyperparathyroidism","Hyperuricemia","Hypokalemia","Hypomagnesemia"]},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"flumetiazid","offLabel":[],"synonyms":["flumethiazide","flumethiazid","flumetiazid","trifluoromethylthiazide"],"timeline":[],"approvals":[],"brandName":"Flumetiazid","ecosystem":[{"indication":"Edema","otherDrugs":[{"name":"acetazolamide","slug":"acetazolamide","company":"Teva Branded Pharm"},{"name":"amiloride","slug":"amiloride","company":"Paddock Llc"},{"name":"bumetanide","slug":"bumetanide","company":""},{"name":"chlorothiazide","slug":"chlorothiazide","company":"Oak Pharms Akorn"}],"globalPrevalence":200000},{"indication":"Hypertensive disorder","otherDrugs":[{"name":"acebutolol","slug":"acebutolol","company":"Promius Pharma"},{"name":"aliskiren","slug":"aliskiren","company":"Novartis"},{"name":"amiloride","slug":"amiloride","company":"Paddock Llc"},{"name":"amlodipine","slug":"amlodipine","company":"Pfizer"}],"globalPrevalence":null}],"mechanism":{"modality":"Small Molecule","drugClass":"flumethiazide","explanation":"Imagine your kidneys as filters that remove waste and excess fluids from your blood. Flumethiazide helps these filters work more efficiently by blocking the reabsorption of sodium and chloride ions, which are essential for maintaining fluid balance in the body. This leads to increased urine production and reduced blood pressure, making it easier for the heart to pump blood and reducing the risk of complications from high blood pressure.","oneSentence":"Flumethiazide works by blocking the reabsorption of sodium and chloride ions in the kidneys, leading to increased urine production and reduced blood pressure.","technicalDetail":"Flumethiazide acts as a competitive inhibitor of the sodium-chloride cotransporter (NCC) in the distal convoluted tubule of the kidneys, leading to increased sodium and chloride excretion in the urine and subsequent diuresis."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/1199","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=FLUMETHIAZIDE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T11:30:56.340899","biosimilars":[],"competitors":[],"genericName":"flumethiazide","indications":{"approved":[{"name":"Edema","source":"DrugCentral","snomedId":267038008,"regulator":"FDA","usPrevalence":null,"globalPrevalence":200000,"prevalenceMethod":"curated","prevalenceSource":"Int Arch Allergy Immunol, 2025 (PMID:39827848)"},{"name":"Hypertensive disorder","source":"DrugCentral","snomedId":38341003,"regulator":"FDA"}],"offLabel":[{"name":"Calcium renal calculus","source":"DrugCentral","drugName":"FLUMETHIAZIDE","evidenceCount":0,"evidenceLevel":"emerging"}],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NUI":"N0000179470","NDDF":"002295","UNII":"3PA0CDS0M5","VUID":"4017728","CHEBI":"CHEBI:135404","VANDF":"4017728","INN_ID":"843","RXNORM":"89911","UMLSCUI":"C0301547","ChEMBL_ID":"CHEMBL2105128","KEGG_DRUG":"D02453","PUBCHEM_CID":"8992","SNOMEDCT_US":"6513000","MESH_SUPPLEMENTAL_RECORD_UI":"C511328"},"formularyStatus":[],"_enricherVersion":"v2","_offLabelChecked":true,"developmentCodes":[],"ownershipHistory":[],"publicationCount":17,"therapeuticAreas":["Cardiovascular"],"biosimilarFilings":[],"recentPublications":[{"date":"1984 Nov","pmid":"6394743","title":"Mechanism for the high bias in the USP colorimetric assay for diazotizable substances in hydrochlorothiazide.","journal":"Journal of pharmaceutical sciences"},{"date":"1963 Mar","pmid":"13963793","title":"Effects of flumethiazide, hydrochlorothiazide and acetazolamide on the intraocular pressure of rabbits receiving fludrocortisone.","journal":"American journal of ophthalmology"},{"date":"1961 Apr 15","pmid":"13698488","title":"Effects of flumethiazide therapy on serum electrolyte levels.","journal":"New York state journal of medicine"},{"date":"1961 Apr","pmid":"13700111","title":"Clinical experience with Rauwolfia-flumethiazide (Rautrax) in the treatment of arterial hypertension.","journal":"The Journal of the Louisiana State Medical Society : official organ of the Louisiana State Medical Society"},{"date":"1960 Dec","pmid":"13717062","title":"Treatment of hypertension with Rauwolfia and flumethiazide.","journal":"Pennsylvania medical journal (1928)"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Flumethiazide is a small molecule drug in the thiazide diuretic class, originally developed by an unknown entity and currently owned by an unknown entity. It is used to treat edema and hypertensive disorders by promoting the excretion of sodium and water in the urine. The commercial status of flumethiazide is unknown, but it is likely used as a generic medication. Key safety considerations include potential electrolyte imbalances and dehydration. As a thiazide diuretic, flumethiazide works by inhibiting the sodium-chloride cotransporter in the distal convoluted tubule of the kidneys.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":true,"safety":false,"trials":false,"score":2}}