{"id":"fludiazepam","rwe":[{"pmid":"38150230","year":"2024","title":"Benzodiazepine Use During Pregnancy and Risk of Miscarriage.","finding":"","journal":"JAMA psychiatry","studyType":"Clinical Study"},{"pmid":"35431916","year":"2022","title":"Asthma Therapies on Pulmonary Tuberculosis Pneumonia in Predominant Bronchiectasis-Asthma Combination.","finding":"","journal":"Frontiers in pharmacology","studyType":"Clinical Study"},{"pmid":"35252385","year":"2022","title":"Relationships Between Bronchodilators, Steroids, Antiarrhythmic Drugs, Antidepressants, and Benzodiazepines and Heart Disease and Ischemic Stroke in Patients With Predominant Bronchiectasis and Asthma.","finding":"","journal":"Frontiers in cardiovascular medicine","studyType":"Clinical Study"},{"pmid":"33584251","year":"2020","title":"Taking Sleeping Pills and the Risk of Chronic Kidney Disease: A Nationwide Population-Based Retrospective Cohort Study.","finding":"","journal":"Frontiers in pharmacology","studyType":"Clinical Study"},{"pmid":"30578721","year":"2019","title":"Characterization and in vitro phase I microsomal metabolism of designer benzodiazepines: An update comprising flunitrazolam, norflurazepam, and 4'-chlorodiazepam (Ro5-4864).","finding":"","journal":"Drug testing and analysis","studyType":"Clinical Study"}],"tags":[{"label":"fludiazepam","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"N05BA17","category":"atc"},{"label":"Active","category":"status"},{"label":"Anti-Anxiety Agents","category":"pharmacology"},{"label":"Anticonvulsants","category":"pharmacology"},{"label":"Central Nervous System Agents","category":"pharmacology"},{"label":"Central Nervous System Depressants","category":"pharmacology"},{"label":"Muscle Relaxants, Central","category":"pharmacology"},{"label":"Neuromuscular Agents","category":"pharmacology"},{"label":"Peripheral Nervous System Agents","category":"pharmacology"},{"label":"Psychotropic Drugs","category":"pharmacology"},{"label":"Tranquilizing Agents","category":"pharmacology"}],"phase":"phase_2","safety":{},"trials":["NCT01574313"],"aliases":[],"patents":[],"pricing":[],"allNames":"erispan","offLabel":[],"synonyms":["fludiazepam","erispan","fludiazepan"],"timeline":[],"approvals":[],"brandName":"Erispan","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"fludiazepam","explanation":"Imagine your brain is like a busy city with many people talking at once. GABA is like a traffic cop that helps calm everyone down and keep the city running smoothly. Fludiazepam helps the traffic cop do its job more effectively, which can lead to a sense of relaxation and reduced anxiety.","oneSentence":"Fludiazepam works by enhancing the calming effect of a neurotransmitter called GABA in the brain.","technicalDetail":"Fludiazepam acts as a positive allosteric modulator of the GABA_A receptor, increasing the frequency of chloride ion channel opening and resulting in hyperpolarization of the neuronal membrane, which ultimately leads to a decrease in neuronal excitability."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/1190","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=FLUDIAZEPAM","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T11:33:00.761742","biosimilars":[],"competitors":[{"drugName":"diazepam","drugSlug":"diazepam","fdaApproval":"1963-11-15","patentExpiry":"Oct 16, 2032","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"chlordiazepoxide","drugSlug":"chlordiazepoxide","fdaApproval":"1960-02-24","genericCount":1,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"oxazepam","drugSlug":"oxazepam","fdaApproval":"1965-06-04","genericCount":12,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"clorazepate","drugSlug":"clorazepate","fdaApproval":"1972-06-23","genericCount":19,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"lorazepam","drugSlug":"lorazepam","fdaApproval":"1977-09-30","patentExpiry":"Jan 8, 2034","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"clobazam","drugSlug":"clobazam","fdaApproval":"2011-10-21","patentExpiry":"Sep 5, 2039","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"prazepam","drugSlug":"prazepam","fdaApproval":"","genericCount":1,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"alprazolam","drugSlug":"alprazolam","fdaApproval":"1981-10-16","genericCount":24,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"halazepam","drugSlug":"halazepam","fdaApproval":"1981-09-24","patentStatus":"Unknown","relationship":"same-class"}],"dataSources":[{"url":"https://clinicaltrials.gov","name":"ClinicalTrials.gov","fields":["trialDetails","trials"],"retrievedDate":"2026-04-07"},{"url":"https://drugcentral.org","name":"DrugCentral","fields":["indications","contraindications","safety","target","drugInteractions"],"retrievedDate":"2026-04-07"}],"genericName":"fludiazepam","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"diazepam","brandName":"diazepam","genericName":"diazepam","approvalYear":"1963","relationship":"same-class"},{"drugId":"chlordiazepoxide","brandName":"chlordiazepoxide","genericName":"chlordiazepoxide","approvalYear":"1960","relationship":"same-class"},{"drugId":"oxazepam","brandName":"oxazepam","genericName":"oxazepam","approvalYear":"1965","relationship":"same-class"},{"drugId":"clorazepate","brandName":"clorazepate","genericName":"clorazepate","approvalYear":"1972","relationship":"same-class"},{"drugId":"lorazepam","brandName":"lorazepam","genericName":"lorazepam","approvalYear":"1977","relationship":"same-class"},{"drugId":"clobazam","brandName":"clobazam","genericName":"clobazam","approvalYear":"2011","relationship":"same-class"},{"drugId":"prazepam","brandName":"prazepam","genericName":"prazepam","approvalYear":"","relationship":"same-class"},{"drugId":"alprazolam","brandName":"alprazolam","genericName":"alprazolam","approvalYear":"1981","relationship":"same-class"},{"drugId":"halazepam","brandName":"halazepam","genericName":"halazepam","approvalYear":"1981","relationship":"same-class"}],"trialDetails":[{"nctId":"NCT01574313","phase":"Phase 4","title":"Effect of Stellate Ganglion Block on Meniere's Disease","status":"COMPLETED","sponsor":"Chi Mei Medical Hospital","isPivotal":false,"enrollment":20,"indication":"Vertigo, Meniere Disease","completionDate":"2012-03"}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"administration":{},"crossReferences":{"UNII":"7F64A2K16Z","CHEBI":"CHEBI:31618","INN_ID":"4089","UMLSCUI":"C0060485","ChEMBL_ID":"CHEMBL13291","KEGG_DRUG":"D01354","DRUGBANK_ID":"DB01567","PUBCHEM_CID":"3369","MESH_SUPPLEMENTAL_RECORD_UI":"C006107"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":31,"therapeuticAreas":["Neuroscience"],"atcClassification":{"source":"DrugCentral","atcCode":"N05BA17","allCodes":["N05BA17"]},"biosimilarFilings":[],"recentPublications":[{"date":"2024 Apr 1","pmid":"38150230","title":"Benzodiazepine Use During Pregnancy and Risk of Miscarriage.","journal":"JAMA psychiatry"},{"date":"2022","pmid":"35431916","title":"Asthma Therapies on Pulmonary Tuberculosis Pneumonia in Predominant Bronchiectasis-Asthma Combination.","journal":"Frontiers in pharmacology"},{"date":"2022","pmid":"35252385","title":"Relationships Between Bronchodilators, Steroids, Antiarrhythmic Drugs, Antidepressants, and Benzodiazepines and Heart Disease and Ischemic Stroke in Patients With Predominant Bronchiectasis and Asthma.","journal":"Frontiers in cardiovascular medicine"},{"date":"2020","pmid":"33584251","title":"Taking Sleeping Pills and the Risk of Chronic Kidney Disease: A Nationwide Population-Based Retrospective Cohort Study.","journal":"Frontiers in pharmacology"},{"date":"2019 Mar","pmid":"30578721","title":"Characterization and in vitro phase I microsomal metabolism of designer benzodiazepines: An update comprising flunitrazolam, norflurazepam, and 4'-chlorodiazepam (Ro5-4864).","journal":"Drug testing and analysis"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Fludiazepam, also known as Erispan, is a small molecule belonging to the drug class of benzodiazepines. Its mechanism of action involves modulating the activity of neurotransmitters in the brain, specifically enhancing the effect of gamma-aminobutyric acid (GABA), which has a calming effect on the nervous system. However, due to the lack of available information, its target, FDA approval status, and commercial status are unknown. As a result, its approved indications, half-life, bioavailability, and generic manufacturers are also unclear. Further research is necessary to determine the full scope of its use and safety considerations.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":true,"score":2}}