{"id":"fluclorolone-acetonide","rwe":[{"pmid":"531939","year":"1979","title":"[Corticosteroid preparations with and without supplementary antibiotics. Comparison of fluclorolone acetonide (Topilar cream) and betamethasone valerate cream (Betnovat) with neomycin].","finding":"","journal":"Ugeskrift for laeger","studyType":"Clinical Study"},{"pmid":"856468","year":"1977","title":"Effects of antiinflammatory agents on mouse skin tumor promotion, epidermal DNA synthesis, phorbol ester-induced cellular proliferation, and production of plasminogen activator.","finding":"","journal":"Cancer research","studyType":"Clinical Study"},{"pmid":"1252855","year":"1976","title":"Long-term treatment with 0-01% fluclorolone acetonide in children.","finding":"","journal":"British medical journal","studyType":"Clinical Study"},{"pmid":"813946","year":"1975","title":"A double-blind evaluation of betamethasone-17, 21-dipropionate (Diproderm ointment) in comparison with fluclorolone acetonide (Topilar ointment) in psoriasis.","finding":"","journal":"Current therapeutic research, clinical and experimental","studyType":"Clinical Study"},{"pmid":"4819137","year":"1974","title":"Development and evaluation of ointment and cream vehicles for a new topical steroid, fluclorolone acetonide.","finding":"","journal":"The British journal of dermatology","studyType":"Clinical Study"}],"tags":[{"label":"fluclorolone acetonide","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"}],"phase":"unknown","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"flucloronide","offLabel":[],"synonyms":["fluclorolone acetonide","flucloronide","flucortolone acetonide"],"timeline":[],"approvals":[],"brandName":"Flucloronide","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"fluclorolone acetonide","explanation":"Imagine your body's immune system as a fire alarm that sounds when it detects something wrong. Flucloronide is like a fire alarm silencer that reduces the alarm's sensitivity, helping to calm down the immune response and reduce inflammation. This can be helpful in treating conditions where the immune system is overactive, but it's not a cure-all and can have side effects if used improperly.","oneSentence":"Flucloronide works by mimicking the effects of cortisol in the body, reducing inflammation and suppressing the immune system.","technicalDetail":"Flucloronide exerts its effects by binding to glucocorticoid receptors, which then translocate to the nucleus and regulate the expression of genes involved in inflammation and immune response. This results in the suppression of pro-inflammatory cytokines and the induction of anti-inflammatory genes, leading to a reduction in inflammation and immune activity."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/3232","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=fluclorolone acetonide","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T11:29:45.861681","biosimilars":[],"competitors":[],"genericName":"fluclorolone acetonide","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NDDF":"003967","UNII":"MG258KTA37","CHEBI":"CHEBI:135787","INN_ID":"2702","RXNORM":"103447","UMLSCUI":"C0352474","ChEMBL_ID":"CHEMBL461332","KEGG_DRUG":"D04201","DRUGBANK_ID":"DB08973","PUBCHEM_CID":"20054914","SNOMEDCT_US":"116583005","MESH_SUPPLEMENTAL_RECORD_UI":"C100065"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":9,"therapeuticAreas":["Immunology"],"biosimilarFilings":[],"recentPublications":[{"date":"1979 Jul 23","pmid":"531939","title":"[Corticosteroid preparations with and without supplementary antibiotics. Comparison of fluclorolone acetonide (Topilar cream) and betamethasone valerate cream (Betnovat) with neomycin].","journal":"Ugeskrift for laeger"},{"date":"1977 May","pmid":"856468","title":"Effects of antiinflammatory agents on mouse skin tumor promotion, epidermal DNA synthesis, phorbol ester-induced cellular proliferation, and production of plasminogen activator.","journal":"Cancer research"},{"date":"1976 Mar 13","pmid":"1252855","title":"Long-term treatment with 0-01% fluclorolone acetonide in children.","journal":"British medical journal"},{"date":"1975 Dec","pmid":"813946","title":"A double-blind evaluation of betamethasone-17, 21-dipropionate (Diproderm ointment) in comparison with fluclorolone acetonide (Topilar ointment) in psoriasis.","journal":"Current therapeutic research, clinical and experimental"},{"date":"1974 Feb","pmid":"4819137","title":"Development and evaluation of ointment and cream vehicles for a new topical steroid, fluclorolone acetonide.","journal":"The British journal of dermatology"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"unknown","modality":"Small Molecule","firstApprovalDate":"","aiSummary":"Flucloronide, also known as fluclorolone acetonide, is a synthetic corticosteroid of the fluclorolone class. It is a small molecule modality, but its exact target and mechanism of action are unknown. Flucloronide is not FDA-approved for any indications, and its commercial status, including patent status and generic availability, is also unknown. As a result, there is limited information available on its safety profile, pharmacokinetics, and clinical use. Further research is needed to fully understand the properties and potential applications of flucloronide.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}