{"id":"flucam-fludara-campath","safety":{"commonSideEffects":[{"rate":null,"effect":"Neutropenia"},{"rate":null,"effect":"Thrombocytopenia"},{"rate":null,"effect":"Anemia"},{"rate":null,"effect":"Infection"},{"rate":null,"effect":"Infusion reactions"},{"rate":null,"effect":"Immunosuppression"}]},"_chembl":{"chemblId":"CHEMBL1201587","moleculeType":"Antibody"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Fludara (fludarabine) is a purine analog that inhibits ribonucleotide reductase and DNA polymerase, leading to apoptosis of lymphoid cells. Campath (alemtuzumab) is a humanized monoclonal antibody targeting CD52 on lymphocytes, causing antibody-dependent cellular cytotoxicity and complement-dependent cytotoxicity. The combination provides enhanced lymphocyte depletion for treating hematologic malignancies.","oneSentence":"FluCAM combines a purine nucleoside analog that inhibits DNA synthesis with a monoclonal antibody that depletes lymphocytes, providing dual immunosuppressive and cytotoxic activity.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:12:49.947Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Chronic lymphocytic leukemia (CLL)"},{"name":"B-cell non-Hodgkin lymphoma"}]},"trialDetails":[],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":3,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["alemtuzumab","fludarabine phosphate","Fludara","Campath"],"phase":"phase_3","status":"active","brandName":"FluCAM [Fludara + Campath]","genericName":"FluCAM [Fludara + Campath]","companyName":"Genzyme, a Sanofi Company","companyId":"genzyme-a-sanofi-company","modality":"Biologic","firstApprovalDate":"","aiSummary":"FluCAM combines a purine nucleoside analog that inhibits DNA synthesis with a monoclonal antibody that depletes lymphocytes, providing dual immunosuppressive and cytotoxic activity. Used for Chronic lymphocytic leukemia (CLL), B-cell non-Hodgkin lymphoma.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":false,"score":3}}