{"id":"flopropione","rwe":[{"pmid":"41592613","year":"2026","title":"Flopropione, a Cysteine Conjugate β-Lyase 1 Inhibitor, for Prevention of Cisplatin-Induced Nephrotoxicity: Protocol for a Randomized, Open-Label, Proof-of-Concept Phase 1 and 2a Trial.","finding":"","journal":"JMIR research protocols","studyType":"Clinical Study"},{"pmid":"40850154","year":"2025","title":"ROS-induced allosteric regulation of NikR coordinates HP0910-mediated OMP2 methylation to modulate H. pylori biofilm dynamics and therapeutic targeting.","finding":"","journal":"Microbiological research","studyType":"Clinical Study"},{"pmid":"38635103","year":"2024","title":"Preoperative diagnosis and safe surgical approach in gallbladder amyloidosis: a case report.","finding":"","journal":"Surgical case reports","studyType":"Clinical Study"},{"pmid":"38508741","year":"2024","title":"Spasmolytic Effect of Flopropione Does Not Involve Catechol-O- methyltransferase (COMT) Inhibition.","finding":"","journal":"Biological & pharmaceutical bulletin","studyType":"Clinical Study"},{"pmid":"38154600","year":"2024","title":"Selective inhibition of overactive warmth-sensitive Ca(2+)-permeable TRPV3 channels by antispasmodic agent flopropione for alleviation of skin inflammation.","finding":"","journal":"The Journal of biological chemistry","studyType":"Clinical Study"}],"tags":[{"label":"Small Molecule","category":"modality"},{"label":"Catechol O-methyltransferase","category":"target"},{"label":"COMT","category":"gene"},{"label":"Active","category":"status"},{"label":"Biliary dyskinesia","category":"indication"},{"label":"Calculus in biliary tract","category":"indication"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"cospanon","offLabel":[],"synonyms":["ephtanon","flopropione","phloropropionone","profenon","propionylphloroglucinol","propiophloroglucine","cospanon"],"timeline":[],"approvals":[],"brandName":"Cospanon","ecosystem":[{"indication":"Biliary dyskinesia","otherDrugs":[],"globalPrevalence":null},{"indication":"Calculus in biliary tract","otherDrugs":[{"name":"chenodiol","slug":"chenodiol","company":""},{"name":"cholic acid","slug":"cholic-acid","company":"Rtrx"},{"name":"ursodiol","slug":"ursodiol","company":"Actavis Labs Ut Inc"}],"globalPrevalence":null}],"mechanism":{"target":"Catechol O-methyltransferase","targets":[{"gene":"COMT","source":"DrugCentral","target":"Catechol O-methyltransferase","protein":"Catechol O-methyltransferase"}],"modality":"Small Molecule","explanation":"Think of bile like a delivery truck that carries waste from your liver to your intestines. Catechol O-methyltransferase is like a traffic cop that helps control the flow of these trucks. By blocking this traffic cop, FLOPROPIONE helps improve the flow of bile and relieve symptoms of biliary dyskinesia and calculus.","oneSentence":"FLOPROPIONE works by inhibiting the enzyme Catechol O-methyltransferase, which plays a role in the regulation of bile flow.","technicalDetail":"FLOPROPIONE acts as a competitive inhibitor of Catechol O-methyltransferase, specifically binding to the enzyme's active site and reducing its ability to methylate catecholamines, thereby increasing the concentration of these compounds and enhancing bile flow."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/1180","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=FLOPROPIONE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T11:31:34.442873","biosimilars":[],"competitors":[{"drugName":"cefotetan","drugSlug":"cefotetan","fdaApproval":"1985-12-27","genericCount":4,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"dobutamine","drugSlug":"dobutamine","fdaApproval":"1978-07-18","genericCount":10,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"entacapone","drugSlug":"entacapone","fdaApproval":"1999-10-19","genericCount":8,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"opicapone","drugSlug":"opicapone","fdaApproval":"2020-04-24","patentExpiry":"Oct 10, 2027","patentStatus":"Patent protected","relationship":"same-target"},{"drugName":"oxyquinoline","drugSlug":"oxyquinoline","fdaApproval":"","relationship":"same-target"},{"drugName":"tolcapone","drugSlug":"tolcapone","fdaApproval":"1998-01-29","genericCount":4,"patentStatus":"Off-patent — generic available","relationship":"same-target"}],"genericName":"flopropione","indications":{"approved":[{"name":"Biliary dyskinesia","source":"DrugCentral","snomedId":197432008,"regulator":"FDA"},{"name":"Calculus in biliary tract","source":"DrugCentral","snomedId":266474003,"regulator":"FDA"}],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"cefotetan","brandName":"cefotetan","genericName":"cefotetan","approvalYear":"1985","relationship":"same-target"},{"drugId":"dobutamine","brandName":"dobutamine","genericName":"dobutamine","approvalYear":"1978","relationship":"same-target"},{"drugId":"entacapone","brandName":"entacapone","genericName":"entacapone","approvalYear":"1999","relationship":"same-target"},{"drugId":"opicapone","brandName":"opicapone","genericName":"opicapone","approvalYear":"2020","relationship":"same-target"},{"drugId":"oxyquinoline","brandName":"oxyquinoline","genericName":"oxyquinoline","approvalYear":"","relationship":"same-target"},{"drugId":"tolcapone","brandName":"tolcapone","genericName":"tolcapone","approvalYear":"1998","relationship":"same-target"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NDDF":"009821","UNII":"05V5NVB5Y1","CHEBI":"CHEBI:31614","INN_ID":"2009","RXNORM":"25082","UMLSCUI":"C0060462","ChEMBL_ID":"CHEMBL1605835","KEGG_DRUG":"D01259","PUBCHEM_CID":"3362","MESH_SUPPLEMENTAL_RECORD_UI":"C014870"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":14,"therapeuticAreas":["Dermatology"],"biosimilarFilings":[],"recentPublications":[{"date":"2026 Feb 12","pmid":"41592613","title":"Flopropione, a Cysteine Conjugate β-Lyase 1 Inhibitor, for Prevention of Cisplatin-Induced Nephrotoxicity: Protocol for a Randomized, Open-Label, Proof-of-Concept Phase 1 and 2a Trial.","journal":"JMIR research protocols"},{"date":"2025 Dec","pmid":"40850154","title":"ROS-induced allosteric regulation of NikR coordinates HP0910-mediated OMP2 methylation to modulate H. pylori biofilm dynamics and therapeutic targeting.","journal":"Microbiological research"},{"date":"2024 Apr 18","pmid":"38635103","title":"Preoperative diagnosis and safe surgical approach in gallbladder amyloidosis: a case report.","journal":"Surgical case reports"},{"date":"2024","pmid":"38508741","title":"Spasmolytic Effect of Flopropione Does Not Involve Catechol-O- methyltransferase (COMT) Inhibition.","journal":"Biological & pharmaceutical bulletin"},{"date":"2024 Feb","pmid":"38154600","title":"Selective inhibition of overactive warmth-sensitive Ca(2+)-permeable TRPV3 channels by antispasmodic agent flopropione for alleviation of skin inflammation.","journal":"The Journal of biological chemistry"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"FLOPROPIONE, also known as Cospanon, is a small molecule modality targeting Catechol O-methyltransferase. It is used to treat biliary dyskinesia and calculus in the biliary tract. The current owner of Cospanon is unknown, and its commercial status is unclear. Further information on its pharmacokinetics and safety profile is also unavailable.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":true,"safety":false,"trials":false,"score":2}}