{"id":"flolan-injection-with-reformulated-diluent","safety":{"commonSideEffects":[{"rate":null,"effect":"Flushing"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Hypotension"},{"rate":null,"effect":"Jaw pain"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Diarrhea"},{"rate":null,"effect":"Catheter-related infections"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Epoprostenol is a prostacyclin analog that binds to prostacyclin receptors on vascular smooth muscle cells, triggering vasodilation and reducing pulmonary artery pressure. It also inhibits platelet aggregation and has antiinflammatory properties. The reformulated diluent in this product improves stability and ease of preparation for continuous intravenous infusion.","oneSentence":"Epoprostenol (prostacyclin) directly relaxes vascular smooth muscle and inhibits platelet aggregation to reduce pulmonary vascular resistance.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:46:34.734Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Pulmonary arterial hypertension (PAH)"},{"name":"Acute pulmonary hypertension during cardiac surgery"}]},"trialDetails":[{"nctId":"NCT02705807","phase":"PHASE4","title":"Evaluation of a New Thermostable Formulation of FLOLAN in Japanese Subjects","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2016-05","conditions":"Cardiovascular Disease","enrollment":10}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"FLOLAN injection with reformulated diluent","genericName":"FLOLAN injection with reformulated diluent","companyName":"GlaxoSmithKline","companyId":"gsk","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Epoprostenol (prostacyclin) directly relaxes vascular smooth muscle and inhibits platelet aggregation to reduce pulmonary vascular resistance. Used for Pulmonary arterial hypertension (PAH), Acute pulmonary hypertension during cardiac surgery.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}