{"id":"flibanserin-flexible-dose","safety":{"commonSideEffects":[{"rate":"10-15","effect":"Dizziness"},{"rate":"8-12","effect":"Nausea"},{"rate":"7-10","effect":"Fatigue"},{"rate":"5-8","effect":"Somnolence"},{"rate":"3-5","effect":"Dry mouth"},{"rate":"2-4","effect":"Hypotension"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"anthropic-haiku","explanation":"Flibanserin works by increasing dopamine and norepinephrine while decreasing serotonin in key brain regions involved in sexual motivation and desire. The drug's agonist activity at 5-HT1A receptors and antagonist activity at 5-HT2A receptors together produce a net effect of enhancing sexual motivation and arousal. This mechanism addresses the neurobiological basis of hypoactive sexual desire disorder (HSDD) in women.","oneSentence":"Flibanserin is a serotonin 5-HT1A receptor agonist and 5-HT2A receptor antagonist that modulates neurotransmitter activity in the brain to increase sexual desire.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:12:47.128Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Hypoactive sexual desire disorder (HSDD) in premenopausal women"}]},"trialDetails":[{"nctId":"NCT00601367","phase":"PHASE3","title":"Flibanserin Evaluation Over 28 Additional Weeks in Hypoactive Sexual Desire Disorder","status":"COMPLETED","sponsor":"Sprout Pharmaceuticals, Inc","startDate":"2008-01","conditions":"Sexual Dysfunctions, Psychological","enrollment":480}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"flibanserin flexible dose","genericName":"flibanserin flexible dose","companyName":"Sprout Pharmaceuticals, Inc","companyId":"sprout-pharmaceuticals-inc","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Flibanserin is a serotonin 5-HT1A receptor agonist and 5-HT2A receptor antagonist that modulates neurotransmitter activity in the brain to increase sexual desire. Used for Hypoactive sexual desire disorder (HSDD) in premenopausal women.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}