{"id":"flexeril-oral-product","safety":{"commonSideEffects":[{"rate":"29","effect":"Drowsiness"},{"rate":"11","effect":"Dizziness"},{"rate":"21","effect":"Dry mouth"},{"rate":"6","effect":"Fatigue"},{"rate":"5","effect":"Headache"}]},"_chembl":{"chemblId":"CHEMBL2108778","moleculeType":"Vaccine component"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Cyclobenzaprine works primarily through central nervous system depression, likely by enhancing the effects of norepinephrine and other neurotransmitters at the brainstem level. It does not directly relax skeletal muscle or affect the neuromuscular junction, but rather reduces motor neuron activity and muscle tone through central mechanisms. The exact molecular target remains incompletely characterized, but it is structurally related to tricyclic antidepressants.","oneSentence":"Flexeril (cyclobenzaprine) is a centrally acting muscle relaxant that reduces muscle spasms by depressing activity in the brainstem.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:30:29.787Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acute muscle spasm and pain associated with musculoskeletal conditions"}]},"trialDetails":[{"nctId":"NCT04240626","phase":"PHASE4","title":"Multimodal Analgesia Effect on Post Surgical Patient","status":"ACTIVE_NOT_RECRUITING","sponsor":"University of California, Davis","startDate":"2021-01-20","conditions":"Obesity, Morbid, Surgery, Bariatric Surgery Candidate","enrollment":60},{"nctId":"NCT02651324","phase":"PHASE4","title":"Efficacy of Ketamine for Improvement in Postoperative Pain Control After Spinal Fusion for Idiopathic Scoliosis","status":"COMPLETED","sponsor":"Albany Medical College","startDate":"2013-05","conditions":"Idiopathic Scoliosis, Post-operative Pain","enrollment":50},{"nctId":"NCT02814565","phase":"PHASE3","title":"Cyclobenzaprine HCl Extended Release 15 mg Versus Placebo in Treatment of Cervical and/or Lower Back Pain Due to Muscle Spasms of Local Origin","status":"COMPLETED","sponsor":"Takeda","startDate":"2016-10-12","conditions":"Neck Pain, Back Pain, Spasm","enrollment":180},{"nctId":"NCT02974166","phase":"NA","title":"Analysis of the Effects of the Osteopathic Manipulative Treatment in Carriers of Temporomandibular Disorders","status":"COMPLETED","sponsor":"Instituto Brasileiro de Osteopatia","startDate":"2012-03","conditions":"Temporomandibular Disorder","enrollment":32},{"nctId":"NCT01587508","phase":"PHASE3","title":"Study Comparing A New Drug Containing The Combination Meloxicam And Cyclobenzaprine In The Treatment Of Acute Lumbago","status":"WITHDRAWN","sponsor":"Eurofarma Laboratorios S.A.","startDate":"2013-05","conditions":"Acute Lumbago","enrollment":""}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Cyclobenziparin"],"phase":"marketed","status":"active","brandName":"Flexeril Oral Product","genericName":"Flexeril Oral Product","companyName":"University of California, Davis","companyId":"university-of-california-davis","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Flexeril (cyclobenzaprine) is a centrally acting muscle relaxant that reduces muscle spasms by depressing activity in the brainstem. Used for Acute muscle spasm and pain associated with musculoskeletal conditions.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}