{"id":"flavonoid","rwe":[],"_fda":{"id":"2d7e9f6a-0f22-b103-e063-6294a90a912f","set_id":"2d7e9f6a-0f21-b103-e063-6294a90a912f","openfda":{"upc":["0889476346184"],"unii":["V13007Z41A"],"route":["AURICULAR (OTIC)"],"rxcui":["2595042"],"spl_id":["2d7e9f6a-0f22-b103-e063-6294a90a912f"],"brand_name":["Lipo Flavonoid Ear Pain Relief Drops with 4% Lidocaine"],"spl_set_id":["2d7e9f6a-0f21-b103-e063-6294a90a912f"],"package_ndc":["69693-901-04"],"product_ndc":["69693-901"],"generic_name":["LIPO FLAVONOID EAR PAIN RELIEF DROPS WITH 4% LIDOCAINE"],"product_type":["HUMAN OTC DRUG"],"substance_name":["LIDOCAINE HYDROCHLORIDE"],"manufacturer_name":["Clarion Brands LLC"],"application_number":["M017"],"is_original_packager":[true]},"purpose":["Topical anesthetic"],"version":"1","warnings":["For external use only Flammable keep away from fire, sparks, and heated surfaces exposure to temperatures above 130°F may cause bursting store at room temperature in a dry place Do not use in large quantities, particularly over raw surfaces or blistered areas for more than one week without consulting a doctor if you have a hole in your ear drum or tubes in your ear"],"questions":["call 1-844-454-7632"],"ask_doctor":["Stop use and ask a doctor if ■ rash or irritation develops ■ if symptoms worsen or persist for more than 7 days or clear up and occur again within a few days"],"when_using":["use only as directed. Read and follow all directions and warning on this label do not allow contact with the eyes and mucous membranes do not use with other topical analgesics Directions adults and children 2 years of age and older: apply to the affected area no more than 3 to 4 times daily children under 2 years of age: ask a doctor this package is child-resistant"],"effective_time":"20250206","active_ingredient":["Lidocaine HCl 4%"],"inactive_ingredient":["alcohol aloe barbadensis leaf juice bisabolol, glycerin isopropyl alcohol maltodextrin water zingiber officinale (ginger) root extract"],"indications_and_usage":["for the temporary relief of pain"],"dosage_and_administration":["Lidocaine HCl 4% Topical anesthetic"],"spl_product_data_elements":["Lipo Flavonoid Ear Pain Relief Drops with 4% Lidocaine Lipo Flavonoid Ear Pain Relief Drops with 4% Lidocaine BISABOLOL ZINGIBER OFFICINALE (GINGER) ROOT OIL WATER MALTODEXTRIN LIDOCAINE HYDROCHLORIDE LIDOCAINE LIDOCAINE HYDROCHLORIDE ANHYDROUS GLYCERIN ALCOHOL ISOPROPYL ALCOHOL ALOE BARBADENSIS LEAF Cylindrical Container"],"keep_out_of_reach_of_children":["If swallowed, get medical help or contact a Poison Control Center right away."],"package_label_principal_display_panel":["NEW! LipoFlavonoid ® #1 ENT DOCTOR RECOMMENDED † EAR PAIN RELIEF DROPS WITH 4% LIDOCAINE for fast acting earache pain relief, plus: Soothe discomfort, swelling, and pressure Helps fight harmful bacteria Swimmers Ear, Cold & Flu, Allergies * FAST ACTING PAIN RELIEF EAR DROPS 0.42 FL OZ (12.4 mL) SAFE & EFFECTIVE FOR CHILDREN 2 years old and up Consult your doctor before using on children under 2 years old. DIRECTIONS: Tilt head and apply 2 to 3 drops into affected ear Hold position for 1 minute Repeat no more than 4 times per day Keep child proof cap tightly closed when stroring DO NOT USE if you have a hole in your ear drum or tubes in your ear. Distributed by: Lipo Flavonoid LLC 811 Broad Street, Suite 600 Chattanooga, TN 37402 ©2025 ENHANCED FORMULA max strength pain relief, plus Helps fight harmful bacteria Quickly dry & relieve water-clogged ears Gently helps flush ear wax and debris * relief from earaches due to swimming, cold & flu, and allergies † data on file Lipoflavonoid Ear Pain Relief Drops Lipoflavonoid Ear Pain Relief Drops"]},"tags":[],"safety":{"boxedWarnings":[]},"trials":[],"_chembl":{"chemblId":"CHEMBL5276536","moleculeType":null,"molecularWeight":"270.28"},"aliases":["MPFF","Tenofovir + SB Flavon"],"patents":[],"pricing":[],"_sources":{"trials":{"url":"https://clinicaltrials.gov/search?intr=Flavonoid","method":"api_direct","source":"ClinicalTrials.gov","rawText":"","confidence":1,"sourceType":"ctgov","retrievedAt":"2026-04-20T01:27:58.619144+00:00"},"timeline":{"url":"https://en.wikipedia.org/wiki/Flavonoid","method":"deterministic","source":"Wikipedia","rawText":"","confidence":0.8,"sourceType":"wikipedia","retrievedAt":"2026-04-20T01:28:05.719359+00:00"},"regulatory.ca":{"url":"","method":"api_direct","source":"Health Canada DPD","rawText":"","confidence":1,"sourceType":"health_canada_dpd","retrievedAt":"2026-04-20T01:28:04.195231+00:00"},"publicationCount":{"url":"https://pubmed.ncbi.nlm.nih.gov/?term=Flavonoid","method":"api_direct","source":"PubMed/NCBI","rawText":"","confidence":1,"sourceType":"pubmed","retrievedAt":"2026-04-20T01:28:04.561308+00:00"},"administration.route":{"url":"","method":"deterministic","source":"FDA Label","rawText":"","confidence":1,"sourceType":"fda_label","retrievedAt":"2026-04-20T01:27:57.251713+00:00"},"safety.boxedWarnings":{"url":"","method":"deterministic","source":"FDA Label (no boxed warning)","rawText":"","confidence":1,"sourceType":"fda_label","retrievedAt":"2026-04-20T01:27:57.251740+00:00"},"crossReferences.chemblId":{"url":"https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL5276536/","method":"api_direct","source":"ChEMBL (EMBL-EBI)","rawText":"","confidence":1,"sourceType":"chembl","retrievedAt":"2026-04-20T01:28:05.366079+00:00"},"regulatory.fda_application":{"url":"","method":"deterministic","source":"FDA Label","rawText":"M017","confidence":1,"sourceType":"fda_label","retrievedAt":"2026-04-20T01:27:57.251744+00:00"}},"offLabel":[],"timeline":[],"_dailymed":{"setId":"2d7e9f6a-0f21-b103-e063-6294a90a912f","title":"LIPO FLAVONOID EAR PAIN RELIEF DROPS WITH 4% LIDOCAINE LIQUID [CLARION BRANDS LLC]"},"ecosystem":[],"_scrapedAt":"2026-03-27T23:30:29.041Z","_scrapedBy":"cloudflare-swarm","_wikipedia":{"url":"https://en.wikipedia.org/wiki/Flavonoid","title":"Flavonoid","extract":"Flavonoids are a class of polyphenolic secondary metabolites found in plants. Blackberry, black currant, chokeberry, and red cabbage are examples of plants with rich contents of flavonoids. In plant biology, flavonoids fulfill diverse functions, including attraction of pollinating insects, antioxidant protection against ultraviolet light, deterrence of environmental stresses and pathogens, and regulation of cell growth."},"references":[],"_validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-20T01:28:07.507844+00:00","fieldsConflicting":0,"overallConfidence":0.95},"biosimilars":[],"competitors":[],"labelChanges":[],"relatedDrugs":[],"trialDetails":[{"nctId":"NCT07433621","phase":"PHASE1","title":"Quercetin in Patients With XIAP (X-linked Inhibitor of Apoptosis) Deficiency","status":"RECRUITING","sponsor":"Children's Hospital Medical Center, Cincinnati","startDate":"2026-02-26","conditions":"XIAP Deficiency","enrollment":12},{"nctId":"NCT07144293","phase":"PHASE2","title":"Improving Physical Ability and Cellular Senescence Elimination in HIV","status":"ACTIVE_NOT_RECRUITING","sponsor":"National Institute of Allergy and Infectious Diseases (NIAID)","startDate":"2025-12-04","conditions":"HIV, Frailty, Prefrail","enrollment":82},{"nctId":"NCT00065676","phase":"PHASE2","title":"Investigating the Use of Quercetin on Glucose Absorption in Obesity, and Obesity With Type 2 Diabetes","status":"COMPLETED","sponsor":"National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)","startDate":"2010-04-30","conditions":"Obesity, Diabetes","enrollment":24},{"nctId":"NCT07487623","phase":"NA","title":"Evaluation of the Hepatoprotective Effects of a Nutritional Supplement in Patients With Liver Disease Secondary to Chronic Hepatitis C Virus Infection (RESQUETI Study).","status":"RECRUITING","sponsor":"University of Guadalajara","startDate":"2025-10-11","conditions":"Liver Disease Chronic, HEPATITIS C VIRUS CHRONIC INFECTION","enrollment":26},{"nctId":"NCT06786494","phase":"NA","title":"Tart Cherry Juice for Sleep in Older Adults With Insomnia: A Pilot Study of Feasibility and Comprehensive Mechanisms","status":"COMPLETED","sponsor":"Courtney Millar","startDate":"2025-01-15","conditions":"Sleep Problems, Insomnia","enrollment":20},{"nctId":"NCT05653258","phase":"PHASE2, PHASE3","title":"Single Nuclei RNA-seq to Map Adipose Cellular Populations and Senescent Cells in Older Subjects","status":"RECRUITING","sponsor":"Cedars-Sinai Medical Center","startDate":"2023-10-17","conditions":"Obesity, Healthy Lifestyle","enrollment":160},{"nctId":"NCT05042245","phase":"PHASE4","title":"The Efficacy and Safety of Ornithine Aspartic Acid Granules in NAFLD Against Silymarin Capsules","status":"COMPLETED","sponsor":"Xinhua Hospital, Shanghai Jiao Tong University School of Medicine","startDate":"2019-07-23","conditions":"Non-alcoholic Fatty Liver Disease","enrollment":237},{"nctId":"NCT07466420","phase":"NA","title":"Study on the Efficacy of Quercetin Intake in Patients With Fibrotic Interstitial Lung Diseases.","status":"RECRUITING","sponsor":"Katerina M. 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