{"id":"fipv-at-6-14-22-weeks-of-age-rotarix","safety":{"commonSideEffects":[{"rate":null,"effect":"Fever"},{"rate":null,"effect":"Irritability"},{"rate":null,"effect":"Loss of appetite"},{"rate":null,"effect":"Diarrhea"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"fIPV is an inactivated polio vaccine administered at reduced (fractional) doses to improve immunization coverage in resource-limited settings while maintaining protective immunity. Rotarix is a live attenuated rotavirus vaccine that replicates in the intestinal tract, inducing mucosal and systemic immune responses. Both vaccines work by priming B and T cells to recognize and neutralize their respective pathogens upon natural exposure.","oneSentence":"fIPV (fractional-dose inactivated poliovirus vaccine) and Rotarix (rotavirus vaccine) stimulate the immune system to produce antibodies against poliovirus and rotavirus, respectively, preventing infection and disease.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:32:50.646Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Prevention of poliomyelitis (fIPV component)"},{"name":"Prevention of rotavirus gastroenteritis (Rotarix component)"}]},"trialDetails":[{"nctId":"NCT02847026","phase":"PHASE4","title":"Fractional Inactivated Poliovirus Vaccine Booster and Rotavirus Study","status":"COMPLETED","sponsor":"Centers for Disease Control and Prevention","startDate":"2016-09","conditions":"Poliomyelitis","enrollment":1144}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"fIPV at 6-14-22 weeks of age, Rotarix","genericName":"fIPV at 6-14-22 weeks of age, Rotarix","companyName":"Centers for Disease Control and Prevention","companyId":"centers-for-disease-control-and-prevention","modality":"Biologic","firstApprovalDate":"","aiSummary":"fIPV (fractional-dose inactivated poliovirus vaccine) and Rotarix (rotavirus vaccine) stimulate the immune system to produce antibodies against poliovirus and rotavirus, respectively, preventing infection and disease. Used for Prevention of poliomyelitis (fIPV component), Prevention of rotavirus gastroenteritis (Rotarix component).","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}