{"id":"fimasartan-hctz-combination","safety":{"commonSideEffects":[{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Fatigue"},{"rate":null,"effect":"Hyperuricemia"},{"rate":null,"effect":"Hypokalemia"},{"rate":null,"effect":"Headache"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Fimasartan is an angiotensin II receptor blocker (ARB) that prevents angiotensin II from binding to AT1 receptors on blood vessels, causing vasodilation and reduced vasoconstriction. Hydrochlorothiazide (HCTZ) is a thiazide diuretic that inhibits sodium and chloride reabsorption in the distal convoluted tubule, promoting urinary excretion of water and electrolytes. The combination provides complementary antihypertensive effects through different mechanisms.","oneSentence":"Fimasartan blocks angiotensin II type 1 receptors to lower blood pressure, while hydrochlorothiazide acts as a thiazide diuretic to reduce fluid volume and further decrease blood pressure.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:46:44.989Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Hypertension"}]},"trialDetails":[{"nctId":"NCT03246555","phase":"PHASE3","title":"Fimasartan in the Senior Subjects","status":"COMPLETED","sponsor":"Boryung Pharmaceutical Co., Ltd","startDate":"2016-07-15","conditions":"The Elderly (≥ 70 Years) With Essential Hypertension","enrollment":241},{"nctId":"NCT03629067","phase":"PHASE1","title":"Combination of Fimasartan/Amlodipine/Hydrochlorothiazide in Healthy Male Subjects","status":"COMPLETED","sponsor":"Boryung Pharmaceutical Co., Ltd","startDate":"2018-09-13","conditions":"Pharmacokinetics","enrollment":60},{"nctId":"NCT03390465","phase":"PHASE1","title":"Drug Interaction Study of Fimasartan/Amlodipine/Hydrochlorothiazide in Healthy Male Subjects","status":"COMPLETED","sponsor":"Boryung Pharmaceutical Co., Ltd","startDate":"2017-12-15","conditions":"Drug-Drug Interaction","enrollment":36},{"nctId":"NCT02222480","phase":"PHASE2","title":"A Clinical Trial to Evaluate Efficacy, Tolerability, and Pharmacokinetic-Pharmacodynamic Relationship of Fimasartan/Hydrochlorothiazide","status":"COMPLETED","sponsor":"Boryung Pharmaceutical Co., Ltd","startDate":"2014-10","conditions":"Hypertension","enrollment":103},{"nctId":"NCT02466490","phase":"PHASE3","title":"Efficacy and Safety of Fimasartan Alone or Combined With HCTZ in Mexican Patients With Essential Hypertension","status":"COMPLETED","sponsor":"Stendhal Americas, S.A.","startDate":"2013-04","conditions":"Hypertension, Essential","enrollment":272},{"nctId":"NCT01258673","phase":"PHASE3","title":"A Clinical Study to Evaluate Efficacy and Safety of Fimasartan/Hydrochlorothiazide Combination-therapy","status":"COMPLETED","sponsor":"Boryung Pharmaceutical Co., Ltd","startDate":"2010-11","conditions":"Essential Hypertension","enrollment":263}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Fimasartan/HCTZ combination","genericName":"Fimasartan/HCTZ combination","companyName":"Boryung Pharmaceutical Co., Ltd","companyId":"boryung-pharmaceutical-co-ltd","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Fimasartan blocks angiotensin II type 1 receptors to lower blood pressure, while hydrochlorothiazide acts as a thiazide diuretic to reduce fluid volume and further decrease blood pressure. Used for Hypertension.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}