{"id":"fibrinogen-thrombin-coated-collagen-patch","safety":{"commonSideEffects":[{"rate":null,"effect":"Infection at surgical site"},{"rate":null,"effect":"Allergic reaction"},{"rate":null,"effect":"Inflammation"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"The patch combines a collagen matrix with fibrinogen and thrombin to accelerate blood coagulation and hemostasis at surgical sites. Thrombin converts fibrinogen to fibrin, which polymerizes to form a stable clot, while the collagen provides structural support and enhances platelet adhesion and aggregation. This combination creates a localized hemostatic environment that reduces bleeding and promotes wound healing.","oneSentence":"A collagen patch coated with fibrinogen and thrombin that promotes hemostasis by providing a scaffold for clot formation and delivering clotting factors directly to the wound site.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T00:39:40.977Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Surgical hemostasis and bleeding control during surgical procedures"}]},"trialDetails":[{"nctId":"NCT05385952","phase":"NA","title":"GATT-Patch Versus TachoSil in Liver Surgery","status":"COMPLETED","sponsor":"GATT Technologies BV","startDate":"2022-08-04","conditions":"Intraoperative Bleeding, Hemorrhage, Surgical, Liver Diseases","enrollment":132},{"nctId":"NCT04660721","phase":"PHASE1, PHASE2","title":"A Study Evaluating the Safety and Preliminary Efficacy of sFilm-FS in Controlling Parenchymal Bleeding During Elective Hepatic Surgery","status":"COMPLETED","sponsor":"Sealantium Medical Ltd.","startDate":"2021-05-12","conditions":"Hemostasis, General Surgery","enrollment":33},{"nctId":"NCT04065880","phase":"NA","title":"Neoveil® Versus TachoSil® for the Treatment of Pulmonary Air Leaks Following Lung Operation","status":"COMPLETED","sponsor":"University Hospital, Basel, Switzerland","startDate":"2020-04-01","conditions":"Prolonged Air Leak, Postoperative Air Leak","enrollment":46},{"nctId":"NCT02311543","phase":"PHASE3","title":"Impact of a Surgical Sealing Patch on Lymphatic Drainage After ALND for Breast Cancer","status":"COMPLETED","sponsor":"Swiss Cancer Institute","startDate":"2015-03-18","conditions":"Breast Cancer","enrollment":142},{"nctId":"NCT01681030","phase":"PHASE2","title":"The Fibrin Pad Cardiovascular Study","status":"COMPLETED","sponsor":"Ethicon, Inc.","startDate":"2012-08-01","conditions":"Cardiovascular Disease","enrollment":42},{"nctId":"NCT03269955","phase":"PHASE4","title":"The Effect of Application of TachoSil® in Pancreatoduodenectomy","status":"UNKNOWN","sponsor":"Asan Medical Center","startDate":"2017-02-27","conditions":"Pancreatic Neoplasm, Pancreatic Periampullary Cancer, Pancreatic Bordeline Tumor","enrollment":126},{"nctId":"NCT02040428","phase":"PHASE3","title":"The Fibrin Pad CV Phase III Study","status":"COMPLETED","sponsor":"Ethicon, Inc.","startDate":"2014-01-01","conditions":"Cardiovascular Disease","enrollment":156},{"nctId":"NCT01500135","phase":"PHASE3","title":"Comparison of Efficacy and Safety of TachoSil® Versus Surgicel® Original for the Secondary Hemostatic Treatment of Needle Hole Bleeding in Vascular Surgery","status":"COMPLETED","sponsor":"Takeda","startDate":"2012-03","conditions":"Bleeding","enrollment":150},{"nctId":"NCT01920958","phase":"","title":"Use of Tachosil® for Lymph Sealing During Surgery","status":"COMPLETED","sponsor":"Takeda","startDate":"2012-09","conditions":"Lymph Node Resection","enrollment":233},{"nctId":"NCT00852826","phase":"PHASE4","title":"Evaluation of a Hemostatic and Sealing Agent to Prevent Surgical Complications After Axillary Lymphadenectomy","status":"COMPLETED","sponsor":"Hospital Universitario Virgen de la Arrixaca","startDate":"2008-01","conditions":"Seroma","enrollment":60}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":15,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["TachoSil®"],"phase":"marketed","status":"active","brandName":"Fibrinogen/thrombin-coated collagen patch","genericName":"Fibrinogen/thrombin-coated collagen patch","companyName":"Asan Medical Center","companyId":"asan-medical-center","modality":"Small molecule","firstApprovalDate":"","aiSummary":"A collagen patch coated with fibrinogen and thrombin that promotes hemostasis by providing a scaffold for clot formation and delivering clotting factors directly to the wound site. Used for Surgical hemostasis and bleeding control during surgical procedures.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}