{"id":"fibrin-sealant-vh-s-d","safety":{"commonSideEffects":[{"rate":null,"effect":"Infection at application site"},{"rate":null,"effect":"Hematoma"},{"rate":null,"effect":"Seroma"},{"rate":null,"effect":"Allergic reaction"}]},"_chembl":{"chemblId":"CHEMBL2108390","moleculeType":"Unknown"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"This product combines human fibrinogen and thrombin to create a physiologic fibrin clot at the site of application. The fibrinogen is converted to fibrin by thrombin, which polymerizes to form a stable clot that adheres to tissue surfaces. The 'S/D' designation indicates solvent/detergent viral inactivation treatment, enhancing safety by reducing pathogenic virus transmission risk.","oneSentence":"Fibrin Sealant VH S/D is a topical hemostatic agent that forms a fibrin clot to seal wounds and control bleeding during surgery.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:12:33.374Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Hemostasis and sealing of surgical wounds during general surgery, cardiovascular surgery, and other surgical procedures"}]},"trialDetails":[{"nctId":"NCT02584153","phase":"PHASE1","title":"A Study of Fibrin Sealant Plus Silver Microparticles to Prevent Incisional Hernias Following Abdominal Surgery","status":"WITHDRAWN","sponsor":"Hobart Harris","startDate":"2019-01","conditions":"Hernia, Ventral Hernia, Abdominal Hernia","enrollment":""},{"nctId":"NCT02891070","phase":"PHASE3","title":"Efficacy and Safety of FS VH S/D 500 S-apr (Tisseel) as an Adjunct to Sutured Dural Repair in Cranial Surgery","status":"COMPLETED","sponsor":"Baxter Healthcare Corporation","startDate":"2016-10-11","conditions":"Cerebrospinal Fluid Leak","enrollment":224},{"nctId":"NCT01112735","phase":"PHASE2","title":"Efficacy and Safety of ARTISS for Flap Adherence in Abdominoplasty","status":"COMPLETED","sponsor":"Baxter Healthcare Corporation","startDate":"2010-05","conditions":"Seroma, Hematoma","enrollment":40},{"nctId":"NCT00157131","phase":"PHASE3","title":"Safety and Efficacy Study of FS 4 IU VH S/D (Fibrin Sealant With 4IU/mL Thrombin, Vapor Heated, Solvent/Detergent Treated) to Adhere Split Thickness Skin Grafts and Improve Wound Healing in Burn Patients","status":"COMPLETED","sponsor":"Baxter Healthcare Corporation","startDate":"2004-06","conditions":"Deep Partial or Full Thickness Wounds","enrollment":150},{"nctId":"NCT00161733","phase":"PHASE3","title":"Safety and Hemostatic Efficacy of Fibrin Sealant Vapor Heated, Solvent/Detergent Treated (FS VH S/D) Compared With Currently Licensed TISSEEL VH Fibrin Sealant in Subjects Undergoing Cardiac Surgery","status":"COMPLETED","sponsor":"Baxter Healthcare Corporation","startDate":"2002-09","conditions":"Cardiac Surgery Requiring Cardiopulmonary Bypass and Median Sternotomy, Cardiopulmonary Bypass, Sternotomy","enrollment":""},{"nctId":"NCT00681824","phase":"PHASE2","title":"Fibrin Sealant for the Sealing of Dura Sutures","status":"COMPLETED","sponsor":"Baxter Healthcare Corporation","startDate":"2008-05","conditions":"Pathological Processes in the Posterior Fossa, Dura Defects","enrollment":95},{"nctId":"NCT01244425","phase":"PHASE2","title":"Fibrin Sealant VH S/D 500 S-apr in Hepatic Resection","status":"COMPLETED","sponsor":"Baxter Healthcare Corporation","startDate":"2010-11","conditions":"Bleeding (Oozing) in Hepatic Resection","enrollment":70},{"nctId":"NCT00892957","phase":"PHASE3","title":"FS VH S/D 500 S-apr in Vascular Surgery","status":"COMPLETED","sponsor":"Baxter Healthcare Corporation","startDate":"2009-07","conditions":"Hemostasis in Participants Receiving Peripheral Vascular Expanded Polytetrafluoroethylene (ePTFE) Graft Prostheses","enrollment":176},{"nctId":"NCT00576420","phase":"PHASE2","title":"Fibrin Sealant Vascular Surgery Study","status":"COMPLETED","sponsor":"Baxter Healthcare Corporation","startDate":"2007-12","conditions":"Adjunct to Hemostasis in Vascular Surgery (Synthetic Vascular Grafts)","enrollment":101},{"nctId":"NCT00708071","phase":"PHASE2","title":"Efficacy and Safety Study of Fibrin Sealant With 4 IU/mL Thrombin, Vapor Heated, Solvent Detergent Treated (FS VH S/D 4) in Face-Lift Procedures","status":"COMPLETED","sponsor":"Baxter Healthcare Corporation","startDate":"2008-06","conditions":"Facial Rhytidectomy (Face-lift)","enrollment":45},{"nctId":"NCT00999141","phase":"PHASE3","title":"Efficacy and Safety of FS VH S/D 4 S-apr for Flap Adherence in Rhytidectomy","status":"COMPLETED","sponsor":"Baxter Healthcare Corporation","startDate":"2009-09","conditions":"Face-lift, Facial Rhytidectomy","enrollment":75},{"nctId":"NCT01320514","phase":"","title":"Efficacy and Safety of Fibrin Sealant (FS) VH S/D-APR for Hemostasis and Wound Healing in Endoscopic Browlift","status":"UNKNOWN","sponsor":"Nguyen, Davis B., M.D.","startDate":"2010-12","conditions":"Compare Ecchymosis and Edema for Fibrin Sealant and no Fibrin Sealant","enrollment":10},{"nctId":"NCT00161980","phase":"PHASE3","title":"Efficacy and Safety of Fibrin Sealant Vapor Heated Solvent/Detergent Treated (FS VH S/D) for Reduction of Lymphatic Leakage by Sealing Axillary Lymph Node Dissection Sites","status":"COMPLETED","sponsor":"Baxter Healthcare Corporation","startDate":"2001-06","conditions":"Breast Cancer, Lumpectomy, Mastectomy Plus Axillary Lymph Node Dissection","enrollment":""},{"nctId":"NCT00161902","phase":"PHASE3","title":"Efficacy and Safety of Fibrin Sealant Vapor Heated Solvent/Detergent Treated (FS VH S/D) for Hemostasis in Subjects Undergoing Total Hip Replacement","status":"COMPLETED","sponsor":"Baxter Healthcare Corporation","startDate":"2001-08","conditions":"Hip Replacement Surgery","enrollment":""}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":5,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Fibrin Sealant VH S/D","genericName":"Fibrin Sealant VH S/D","companyName":"Baxter Healthcare Corporation","companyId":"baxter-healthcare-corporation","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Fibrin Sealant VH S/D is a topical hemostatic agent that forms a fibrin clot to seal wounds and control bleeding during surgery. Used for Hemostasis and sealing of surgical wounds during general surgery, cardiovascular surgery, and other surgical procedures.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}