{"id":"fibrin-sealant-hemipelvis","safety":{"commonSideEffects":[{"rate":null,"effect":"Infection at surgical site"},{"rate":null,"effect":"Hematoma formation"},{"rate":null,"effect":"Allergic reaction"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Fibrin sealant is a topical hemostatic agent composed of fibrinogen and thrombin that polymerizes at the wound site to create a stable fibrin clot. It is applied directly to bleeding surfaces during surgery to promote rapid hemostasis and reduce blood loss. The product is particularly used in hemipelvis procedures where achieving hemostasis in complex pelvic anatomy is challenging.","oneSentence":"Fibrin sealant forms a hemostatic plug by cross-linking fibrin and thrombin to achieve rapid hemostasis at surgical sites.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T01:12:41.781Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Hemostasis in hemipelvis surgical procedures"}]},"trialDetails":[{"nctId":"NCT03914963","phase":"PHASE3","title":"Efficacy of a Fibrin Sealant for the Prevention of Lymphocele After Lymphadenectomy","status":"COMPLETED","sponsor":"IBON JAUNARENA","startDate":"2012-02-01","conditions":"Lymphocele","enrollment":82}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Fibrin sealant hemipelvis","genericName":"Fibrin sealant hemipelvis","companyName":"IBON JAUNARENA","companyId":"ibon-jaunarena","modality":"Biologic","firstApprovalDate":"","aiSummary":"Fibrin sealant has been studied as a potential treatment for preventing lymphocele after lymphadenectomy. Fibrin sealant is a substance derived from human fibrin, a protein involved in blood clotting.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}