{"id":"fibrin-sealant-fs-grifols","safety":{"commonSideEffects":[{"rate":null,"effect":"Allergic reaction"},{"rate":null,"effect":"Infection at surgical site"},{"rate":null,"effect":"Thromboembolism (rare)"}]},"_chembl":{"chemblId":"CHEMBL2108390","moleculeType":"Unknown"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Fibrin sealant works by mimicking the final steps of the coagulation cascade. When fibrinogen and thrombin components are mixed at the surgical site, thrombin converts fibrinogen into fibrin monomers, which polymerize to form a stable clot. This provides mechanical hemostasis and tissue adhesion without systemic absorption, making it useful for controlling bleeding during surgery.","oneSentence":"Fibrin sealant is a topical hemostatic agent that forms a fibrin clot by combining fibrinogen and thrombin to achieve rapid hemostasis at surgical sites.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:11:54.695Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Hemostasis and tissue adhesion during surgical procedures"},{"name":"Control of bleeding in general surgery, cardiovascular surgery, and other surgical applications"}]},"trialDetails":[{"nctId":"NCT03461406","phase":"PHASE3","title":"A Study of Safety and Efficacy of Fibrin Sealant Grifols as an Adjunct to Haemostasis During Surgery in Paediatric Participants","status":"COMPLETED","sponsor":"Instituto Grifols, S.A.","startDate":"2019-01-18","conditions":"Excessive Bleeding During Surgery","enrollment":186},{"nctId":"NCT01662856","phase":"PHASE3","title":"Safety and Efficacy Study of Fibrin Sealant Grifols as an Adjunct to Hemostasis During Peripheral Vascular Surgery","status":"COMPLETED","sponsor":"Instituto Grifols, S.A.","startDate":"2012-08","conditions":"Vascular Surgical Bleeding","enrollment":225},{"nctId":"NCT01731938","phase":"PHASE3","title":"Safety and Efficacy of Fibrin Sealant Grifols (FS Grifols) During Soft Tissue Open Surgeries","status":"COMPLETED","sponsor":"Grifols Biologicals, LLC","startDate":"2012-11","conditions":"Soft Tissue Surgical Bleeding","enrollment":327},{"nctId":"NCT01754480","phase":"PHASE3","title":"Safety and Efficacy of Fibrin Sealant Grifols (FS Grifols) During Parenchymous Tissue Open Surgeries","status":"COMPLETED","sponsor":"Instituto Grifols, S.A.","startDate":"2013-03","conditions":"Parenchymous Tissue Surgical Bleeding","enrollment":325},{"nctId":"NCT00684047","phase":"PHASE2, PHASE3","title":"Safety and Efficacy Study of Fibrin Sealant Grifols Evaluated as an Adjunct to Hemostasis","status":"COMPLETED","sponsor":"Instituto Grifols, S.A.","startDate":"2008-02","conditions":"Target Bleeding Site During Peripheral Vascular Surgery","enrollment":239}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":5,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Fibrin Sealant (FS) Grifols","genericName":"Fibrin Sealant (FS) Grifols","companyName":"Grifols Biologicals, LLC","companyId":"grifols-biologicals-llc","modality":"Biologic","firstApprovalDate":"","aiSummary":"Fibrin sealant is a topical hemostatic agent that forms a fibrin clot by combining fibrinogen and thrombin to achieve rapid hemostasis at surgical sites. Used for Hemostasis and tissue adhesion during surgical procedures, Control of bleeding in general surgery, cardiovascular surgery, and other surgical applications.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}