{"id":"fibrin-adhesive","safety":{"commonSideEffects":[{"rate":null,"effect":"Infection at application site"},{"rate":null,"effect":"Allergic reaction"},{"rate":null,"effect":"Thrombosis (rare)"}]},"_chembl":{"chemblId":"CHEMBL2108390","moleculeType":"Unknown"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Fibrin adhesive is composed of fibrinogen and thrombin that, when mixed, rapidly polymerize to form a fibrin clot at the site of application. This provides both hemostatic control and mechanical adhesion between tissue surfaces, facilitating wound healing and reducing bleeding during surgical procedures. The adhesive is gradually resorbed as the wound heals.","oneSentence":"Fibrin adhesive acts as a biological glue that promotes hemostasis and tissue adhesion by mimicking the final stages of the coagulation cascade to form a stable fibrin clot.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:12:31.953Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Surgical hemostasis and tissue adhesion"},{"name":"Wound healing and tissue sealing in surgical applications"}]},"trialDetails":[{"nctId":"NCT04236739","phase":"PHASE3","title":"Comparing Clinical Outcomes of the One-step Cartilage Transplantation in Cartilage Defects of the Knee With Conservative Treatment","status":"COMPLETED","sponsor":"R.J.H. Custers","startDate":"2019-07-23","conditions":"Cartilage Damage","enrollment":60},{"nctId":"NCT07455591","phase":"PHASE4","title":"A Trial of Intraoperative Fibrin Sealant on Postoperative Recovery After Total Knee Replacement","status":"COMPLETED","sponsor":"Singapore General Hospital","startDate":"2024-01-01","conditions":"Osteo Arthritis of the Knee","enrollment":78},{"nctId":"NCT05385952","phase":"NA","title":"GATT-Patch Versus TachoSil in Liver Surgery","status":"COMPLETED","sponsor":"GATT Technologies BV","startDate":"2022-08-04","conditions":"Intraoperative Bleeding, Hemorrhage, Surgical, Liver Diseases","enrollment":132},{"nctId":"NCT04234971","phase":"PHASE4","title":"Cost Effectiveness in Alveolar Bone Grafting in Patients With Cleft Lip and Palate","status":"RECRUITING","sponsor":"The University of Texas Health Science Center, Houston","startDate":"2021-06-14","conditions":"Cleft Lip and Palate","enrollment":40},{"nctId":"NCT04537013","phase":"NA","title":"Clinical Study of Chondro-Gide® for Large Chondral Lesions in the Knee","status":"TERMINATED","sponsor":"Geistlich Pharma AG","startDate":"2020-08-26","conditions":"Knee Injuries, Cartilage Injury, Cartilage Disease","enrollment":82},{"nctId":"NCT05553132","phase":"PHASE1","title":"A Study of REcycled CartiLage Auto/Allo IMplantation to Treat and Repair Focal Hip Cartilage Defects","status":"ACTIVE_NOT_RECRUITING","sponsor":"Daniel B. F. Saris","startDate":"2023-08-08","conditions":"Cartilage Defect","enrollment":15},{"nctId":"NCT07360730","phase":"NA","title":"High-Purity Type I Collagen Nerve Wrapping in Peripheral Nerve Procedures: A Prospective Registry","status":"RECRUITING","sponsor":"Adichunchanagiri Institute of Medical Sciences, B G Nagara","startDate":"2025-12-09","conditions":"Peripheral Nerve Injuries, Neuroma of Nerve Repair, Nerve Graft; Complications, Mechanical","enrollment":40},{"nctId":"NCT06319287","phase":"PHASE2","title":"Phase 2a Multi-Center Prospective, Randomized Trial to Evaluate the Safety & Efficacy of Topical PEP-TISSEEL for Diabetic Foot Ulcers (DFU)","status":"COMPLETED","sponsor":"Rion Inc.","startDate":"2024-02-27","conditions":"Diabetic Foot Ulcer","enrollment":59},{"nctId":"NCT07352410","phase":"NA","title":"High-Purity Type I Collagen Augmentation in Meniscal Repair","status":"RECRUITING","sponsor":"Adichunchanagiri Institute of Medical Sciences, B G Nagara","startDate":"2026-01-03","conditions":"Meniscus Tear, Knee Meniscus Injury, Meniscal Repair","enrollment":15},{"nctId":"NCT03255174","phase":"PHASE3","title":"The EVARREST® Pediatric Mild or Moderate Liver and Soft Tissue Bleeding Study","status":"COMPLETED","sponsor":"Ethicon, Inc.","startDate":"2018-03-20","conditions":"Controlling Mild to Moderate Bleeding During Surgery","enrollment":35},{"nctId":"NCT02375802","phase":"PHASE1","title":"Adipose-Derived Stromal Cells (ASC's) for Pressure Ulcers","status":"ENROLLING_BY_INVITATION","sponsor":"Mayo Clinic","startDate":"2015-07","conditions":"Pressure Ulcer","enrollment":12},{"nctId":"NCT07320378","phase":"EARLY_PHASE1","title":"Clinical Study on the Safety and Efficacy of Tendon Stem Progenitor Cells Therapy for Rotator Cuff Tears","status":"NOT_YET_RECRUITING","sponsor":"Second Affiliated Hospital, School of Medicine, Zhejiang University","startDate":"2026-05","conditions":"Rotator Cuff Tendinopathy","enrollment":107},{"nctId":"NCT02307916","phase":"PHASE2","title":"Fibroblast Growth Factor Regeneration of Tympanic Membrane Perforations","status":"COMPLETED","sponsor":"D. Bradley Welling, MD, PhD","startDate":"2016-10","conditions":"Tympanic Membrane Perforation","enrollment":57},{"nctId":"NCT06448039","phase":"PHASE1, PHASE2","title":"In-office Repair of Chronic Tympanic Membrane Perforations","status":"SUSPENDED","sponsor":"D. Bradley Welling, MD, PhD","startDate":"2024-06-15","conditions":"Chronic Tympanic Membrane Perforation","enrollment":20},{"nctId":"NCT04960384","phase":"PHASE2","title":"Fibroblast Growth Factor Regeneration of Tympanic Membrane Perforations","status":"COMPLETED","sponsor":"NYU Langone Health","startDate":"2022-05-27","conditions":"Tympanic Membrane Perforation","enrollment":52},{"nctId":"NCT07216157","phase":"NA","title":"NoSeal Trial: Comparing Sealants Versus No Sealant for Preventing CSF Leak After Endonasal Skull Base Surgery","status":"RECRUITING","sponsor":"Maria Sklodowska-Curie National Research Institute of Oncology","startDate":"2025-08-15","conditions":"CerebroSpinal Fluid (CSF) Leak","enrollment":225},{"nctId":"NCT06296056","phase":"PHASE1","title":"Phase I Trial of Combined Immune Cell Therapy for Metastatic Stage IV Solid Tumors (SDH-Combi)","status":"COMPLETED","sponsor":"Seoul Hospital","startDate":"2024-08-01","conditions":"Solid Tumors, Metastatic","enrollment":9},{"nctId":"NCT07113886","phase":"NA","title":"Guided Bone Regeneration Using a Mixture of Autogenous and Xenograft Particulate Versus Patient-Specific Sticky Bone for Horizontal Anterior Maxillary Defect","status":"NOT_YET_RECRUITING","sponsor":"Cairo University","startDate":"2025-08-30","conditions":"Sticky Bone","enrollment":20},{"nctId":"NCT04838028","phase":"","title":"Chronic Postoperative Pain After Laparoendoscopic Groin Hernia Repair","status":"COMPLETED","sponsor":"Karolinska Institutet","startDate":"2012-09-01","conditions":"Postoperative Pain, Chronic Pain","enrollment":15360},{"nctId":"NCT03847857","phase":"PHASE3","title":"Study of Porcine Fibrin Sealant in Preventing Cervical Anastomotic Leakage (PLACE030)","status":"ACTIVE_NOT_RECRUITING","sponsor":"Sun Yat-sen University","startDate":"2019-02-21","conditions":"Esophageal Anastomotic Leak","enrollment":360},{"nctId":"NCT06756984","phase":"","title":"Long-Term Outcomes of Different Surgical Techniques for Sacral Tarlov Cysts: A Prospective Cohort Study","status":"NOT_YET_RECRUITING","sponsor":"Beijing Jishuitan Hospital","startDate":"2025-05-13","conditions":"Sacral Tarlov Cysts, Symptomatic Sacral Cysts, Chronic Pain Related to Sacral Cysts","enrollment":150},{"nctId":"NCT06964763","phase":"NA","title":"A Trial in Mini-invasive Pilonidal Sinus Disease Surgery","status":"ENROLLING_BY_INVITATION","sponsor":"Helsinki University Central Hospital","startDate":"2023-09-01","conditions":"Pilonidal Disease","enrollment":188},{"nctId":"NCT06961045","phase":"NA","title":"Computer - Guided Inferior Alveolar Nerve Lateralization With Simultaneous Prosthetic Driven Implant Placement Will be Performed on 10 Surgical Sides (Mandibular Quadrants) to Evaluate the Postoperative Neurosensory Disturbances Following Guided Inferior Alveolar Nerve Lateralization","status":"ENROLLING_BY_INVITATION","sponsor":"AYMAN M. ARAKEEP, MSc, PhD researcher","startDate":"2024-02-21","conditions":"Neurosensory Function of Inferior Alveolar Nerve","enrollment":10},{"nctId":"NCT06754046","phase":"NA","title":"BELIEVE Trial: Bulking vErsus sLing for Treating Stress Urinary IncontinEnce at the Time of Vaginal prolapsE Repair (BELIEVE)","status":"RECRUITING","sponsor":"University Hospitals Cleveland Medical Center","startDate":"2025-05-01","conditions":"Stress Urinary Incontinence, Vaginal Prolapse","enrollment":476},{"nctId":"NCT06620952","phase":"","title":"Effect of the \"O-ring\" Technique in Reducing Cerebrospinal Fluid Leak in Posterior Fossa Surgery: an Explorative Study","status":"COMPLETED","sponsor":"Fondazione IRCCS Policlinico San Matteo di Pavia","startDate":"2024-07-16","conditions":"Posterior Fossa Surgery","enrollment":35},{"nctId":"NCT06944132","phase":"NA","title":"CsA vs MMC for Preventing Pterygium Recurrence","status":"COMPLETED","sponsor":"Benha University","startDate":"2024-04-01","conditions":"Pterygium, Pterygium of the Conjunctiva and Cornea","enrollment":40},{"nctId":"NCT03449082","phase":"PHASE2","title":"Treatment of Intractable Common Extensor Tendon Injury Using Mesenchymal Stem Cells (Allo-ASC)","status":"COMPLETED","sponsor":"Seoul National University Hospital","startDate":"2018-03-15","conditions":"Lateral Epicondylitis","enrollment":30},{"nctId":"NCT06793748","phase":"PHASE1, PHASE2","title":"Study to Evaluate the Safety, Tolerability, and Efficacy of PEP-TISSEEL in Subjects With Chronic Radiation Ulcer","status":"NOT_YET_RECRUITING","sponsor":"Rion Inc.","startDate":"2025-06","conditions":"Chronic Radiation Ulcer","enrollment":184},{"nctId":"NCT06897098","phase":"PHASE1","title":"Regeneration of Knee and Ankle Cartilage From Autologous Cartilage Mini-grafts (From the Patient's Own Cells)","status":"ACTIVE_NOT_RECRUITING","sponsor":"Vanarix SA","startDate":"2022-06-10","conditions":"Cartilage Repair","enrollment":11},{"nctId":"NCT06897111","phase":"PHASE1, PHASE2","title":"Implantation of Cartilage Mini-grafts Made From Donor Cells to Treat Chondral Lesions of the Knee","status":"ACTIVE_NOT_RECRUITING","sponsor":"Vanarix SA","startDate":"2024-06-17","conditions":"Cartilage Repair","enrollment":10},{"nctId":"NCT04660721","phase":"PHASE1, PHASE2","title":"A Study Evaluating the Safety and Preliminary Efficacy of sFilm-FS in Controlling Parenchymal Bleeding During Elective Hepatic Surgery","status":"COMPLETED","sponsor":"Sealantium Medical Ltd.","startDate":"2021-05-12","conditions":"Hemostasis, General Surgery","enrollment":33},{"nctId":"NCT04785092","phase":"NA","title":"All Autologous Cartilage Regeneration in the Treatment of the Knee Cartilage Defects","status":"COMPLETED","sponsor":"Istituto Ortopedico Rizzoli","startDate":"2021-03-01","conditions":"Cartilage Damage, Cartilage Disease","enrollment":20},{"nctId":"NCT06840561","phase":"PHASE2","title":"Local Triamcinolone Injection Combined With Fibrin Glue Spray in Preventing Esophageal Stricture After Big-range Endoscopic Submucosal Dissection for Esophageal Early Cancer","status":"COMPLETED","sponsor":"Sun Yat-Sen University Cancer Center","startDate":"2021-11-24","conditions":"Esophageal Stricture, Endoscopic Submucosal Dissection, Early Esophageal Cancer or Precancerous Lesions Treated With Endoscopic Resection","enrollment":20},{"nctId":"NCT06784232","phase":"","title":"Alveolar Ridge Preservation: Biologically-oriented Alveolar Ridge Preservation Vs Modified Periosteal Inhibition","status":"ACTIVE_NOT_RECRUITING","sponsor":"International Piezosurgery Academy","startDate":"2024-12-01","conditions":"Alveolar Ridge Preservation, Alveolar Bone Loss","enrollment":30},{"nctId":"NCT04602689","phase":"NA","title":"Fibrin Glue After ESD for High Risk Patients of Bleeding","status":"COMPLETED","sponsor":"Seoul National University Hospital","startDate":"2020-10-30","conditions":"Early Gastric Cancer, Gastric Adenoma","enrollment":134},{"nctId":"NCT04875767","phase":"NA","title":"Cartilage Repair Using a Hyaluronic Acid-Based Scaffold With Bone Marrow Aspirate Compared With Microfracture for Focal Articular Cartilage Damage of the Hip","status":"WITHDRAWN","sponsor":"McMaster University","startDate":"2023-01-03","conditions":"Femoroacetabular Impingement, Cartilage Damage","enrollment":""},{"nctId":"NCT06679504","phase":"","title":"Laparoscopic Totally Extraperitoneal Inguinal Hernia Repair With Fibrin Glue Versus Tack Mesh Fixation","status":"COMPLETED","sponsor":"Suez Canal University","startDate":"2022-07-01","conditions":"Inguinal Hernia","enrollment":80},{"nctId":"NCT02636881","phase":"NA","title":"Autologous Cartilage Implantation vs Arthroscopic Debridement","status":"COMPLETED","sponsor":"University Hospital, Akershus","startDate":"2016-04","conditions":"Knee Injury, Cartilage Injury","enrollment":28},{"nctId":"NCT01000116","phase":"NA","title":"Fibrin Glue Versus Tacked Fixation in Groin Hernia Repair (TAPP)","status":"COMPLETED","sponsor":"Zealand University Hospital","startDate":"2009-09","conditions":"Inguinal Hernia, Femoral Hernia","enrollment":112},{"nctId":"NCT06449131","phase":"PHASE2","title":"Persistent Pleural Effusion Treatment Following Cardiothoracic Surgery by Platelet-Fibrin Glue","status":"COMPLETED","sponsor":"Daryoush Hamidi Alamdari, PhD","startDate":"2017-05-01","conditions":"Pleural Effusion","enrollment":19},{"nctId":"NCT01022164","phase":"PHASE4","title":"Use of Fibrin Glue in Vitreoretinalsurgery","status":"TERMINATED","sponsor":"Asociación para Evitar la Ceguera en México","startDate":"2009-05","conditions":"Surgery","enrollment":50},{"nctId":"NCT02090140","phase":"NA","title":"Microfracture Versus Adipose Derived Stem Cells for the Treatment of Articular Cartilage Defects","status":"RECRUITING","sponsor":"University of Colorado, Denver","startDate":"2015-11","conditions":"Degenerative Lesion of Articular Cartilage of Knee","enrollment":17},{"nctId":"NCT05983302","phase":"PHASE2, PHASE3","title":"Elimination of Odor and Treatment of Malodorous Recalcitrant Wounds by Using Supraz and PRP-FG Versus Standard of Care","status":"RECRUITING","sponsor":"Mashhad University of Medical Sciences","startDate":"2023-08-20","conditions":"Wounds and Injuries","enrollment":40},{"nctId":"NCT05741983","phase":"NA","title":"AMIC vs. MFx in the Ankle","status":"WITHDRAWN","sponsor":"Geistlich Pharma AG","startDate":"2023-04-28","conditions":"Osteochondral Lesion of Talus, Chondral Defect, Microfracture","enrollment":""},{"nctId":"NCT04931615","phase":"PHASE4","title":"ARTISS a Single-centre Randomised Control Study","status":"COMPLETED","sponsor":"Mid and South Essex NHS Foundation Trust","startDate":"2022-02-01","conditions":"Breast Neoplasms, Mammaplasty","enrollment":135},{"nctId":"NCT06124209","phase":"PHASE4","title":"Use of Fibrin Sealant Patch for Vein Anastomosis During Deceased Donor Liver Transplantation- Randomized Clinical Trial","status":"UNKNOWN","sponsor":"Medical University of Warsaw","startDate":"2023-11-04","conditions":"Liver Transplant; Complications","enrollment":170},{"nctId":"NCT05666206","phase":"NA","title":"Efficacy of Fibrin Sealant in Hypospadias Surgery","status":"UNKNOWN","sponsor":"Al-Azhar University","startDate":"2022-01-01","conditions":"Hypospadias","enrollment":200},{"nctId":"NCT06220877","phase":"NA","title":"Efficacy of Buccal Pad of Fat, Advanced Platelet Rich Fibrin, Fibrin Glue and Oxidized Cellulose Plug in Management of Oro-Antral Communication, Comparative Clinical Study","status":"COMPLETED","sponsor":"October 6 University","startDate":"2019-01-01","conditions":"Healthy Volunteers Only","enrollment":24},{"nctId":"NCT06151912","phase":"NA","title":"The Effect of Staple Line Reinforcement Procedures on Postoperative Nausea and Vomiting in Sleeve Gastrectomy","status":"UNKNOWN","sponsor":"Sakarya University","startDate":"2023-06-01","conditions":"Bariatric Surgical Procedures, Nausea, Postoperative, Vomiting, Postoperative","enrollment":30},{"nctId":"NCT06092398","phase":"NA","title":"Role of Autologous Platelet Rich Plasma(PRP) Injection and Platelet Rich Fibrin Glue(PRFG) Interposition for Treatment of Anal Fistula","status":"NOT_YET_RECRUITING","sponsor":"Assiut University","startDate":"2024-09","conditions":"Anal Fistula","enrollment":60},{"nctId":"NCT05536492","phase":"NA","title":"Sticky Bone Compared to A-PRF(Platlet Rich Fibrin) Effect on Alveolar Ridge Preservation","status":"COMPLETED","sponsor":"Arab American University (Palestine)","startDate":"2022-09-07","conditions":"A-PRF, ALLOGRAFT","enrollment":17},{"nctId":"NCT05850611","phase":"EARLY_PHASE1","title":"The Effect of Combination Therapy of Oral MB and PRP-FG in Patients With Non-healing Diabetic Foot Ulcer","status":"UNKNOWN","sponsor":"Mashhad University of Medical Sciences","startDate":"2023-04-30","conditions":"Diabetic Foot Ulcers, Diabetic Wound","enrollment":20},{"nctId":"NCT05971914","phase":"NA","title":"Alveolar Cleft Hard- and Soft Tissue Reconstruction With an Autogenous Tooth Derived Particulate Graft","status":"UNKNOWN","sponsor":"Semmelweis University","startDate":"2021-10-12","conditions":"Cleft Lip and Palate","enrollment":8},{"nctId":"NCT05946889","phase":"","title":"Comparisons of Human Fibrin Glue (Tisseel) Versus Suture and Robotic Versus Traditional Laparoscopy for Ovarian Cystectomy","status":"COMPLETED","sponsor":"Far Eastern Memorial Hospital","startDate":"2022-09-23","conditions":"Women With Ovarian Cyst","enrollment":88},{"nctId":"NCT06027528","phase":"NA","title":"Evaluation of Socket Preservation Using Autogenous Dentine Graft With Or Without Autologous Fibrin Glue","status":"UNKNOWN","sponsor":"Cairo University","startDate":"2023-09-01","conditions":"Unrestorable Dentition","enrollment":20},{"nctId":"NCT04664738","phase":"PHASE1","title":"PEP on a Skin Graft Donor Site Wound","status":"UNKNOWN","sponsor":"Rion Inc.","startDate":"2021-03-16","conditions":"Skin Graft","enrollment":8},{"nctId":"NCT02227992","phase":"PHASE3","title":"The EVARREST® Paediatric Mild/Moderate Liver and Soft Tissue Bleeding Study","status":"COMPLETED","sponsor":"Ethicon, Inc.","startDate":"2014-07-01","conditions":"Hemorrhage, Soft Tissue Bleeding, Hepatic Parenchyma Bleeding","enrollment":40},{"nctId":"NCT04744402","phase":"PHASE2","title":"Phase 2 Clinical Trial of CartiLife® in the United States","status":"UNKNOWN","sponsor":"Biosolution Co., Ltd.","startDate":"2020-10-28","conditions":"Articular Cartilage Defect, Articular Cartilage Degeneration","enrollment":25},{"nctId":"NCT05986201","phase":"","title":"Assessment of Long-term Effects of Tachosil","status":"COMPLETED","sponsor":"University of Catania","startDate":"2016-02-01","conditions":"Fibrin Sealant, Haemostasis","enrollment":40},{"nctId":"NCT01641718","phase":"NA","title":"Use of Human Fibrin Glue Versus Staples for Mesh Fixation in Laparoscopic Transabdominal Preperitoneal Hernioplasty","status":"COMPLETED","sponsor":"Sascha Müller","startDate":"2013-01","conditions":"Hernia, Inguinal","enrollment":82},{"nctId":"NCT02309645","phase":"PHASE3","title":"The Paediatric EVICEL® Neuro Study","status":"TERMINATED","sponsor":"Ethicon, Inc.","startDate":"2014-10-01","conditions":"CSF Leak","enrollment":40},{"nctId":"NCT04643106","phase":"NA","title":"Comparison of Hemostatic Agent to Suture in Terms of Hemostatic Function and Preservation of Ovarian Function","status":"RECRUITING","sponsor":"Seoul National University Hospital","startDate":"2021-02-25","conditions":"Benign Ovarian Cyst","enrollment":90},{"nctId":"NCT04065880","phase":"NA","title":"Neoveil® Versus TachoSil® for the Treatment of Pulmonary Air Leaks Following Lung Operation","status":"COMPLETED","sponsor":"University Hospital, Basel, Switzerland","startDate":"2020-04-01","conditions":"Prolonged Air Leak, Postoperative Air Leak","enrollment":46},{"nctId":"NCT03331718","phase":"PHASE3","title":"PoLyglycolic Acid Felt reiNforcEmenT of the PancreaticoJejunostomy (PLANET-PJ Trial)","status":"UNKNOWN","sponsor":"University of Toyama","startDate":"2018-10-10","conditions":"Disease of Pancreatic or Periampullary Lesions","enrollment":514},{"nctId":"NCT00504582","phase":"NA","title":"Fibrin Melanoma Axillary Node Study in Patients With Melanoma","status":"COMPLETED","sponsor":"M.D. Anderson Cancer Center","startDate":"2002-05-15","conditions":"Melanoma","enrollment":121},{"nctId":"NCT05831267","phase":"NA","title":"Fibrin Glue Versus Titanium Platelet-rich Fibrin in Lateral Sinus Lifting","status":"COMPLETED","sponsor":"Hams Hamed Abdelrahman","startDate":"2022-02-01","conditions":"Sinus Floor Augmentation, Graftless Sinus Elevation","enrollment":30},{"nctId":"NCT03461406","phase":"PHASE3","title":"A Study of Safety and Efficacy of Fibrin Sealant Grifols as an Adjunct to Haemostasis During Surgery in Paediatric Participants","status":"COMPLETED","sponsor":"Instituto Grifols, S.A.","startDate":"2019-01-18","conditions":"Excessive Bleeding During Surgery","enrollment":186},{"nctId":"NCT05771038","phase":"EARLY_PHASE1","title":"Assessment of Bone Quality After Socket Preservation Using Sodium Alendronate Gel Compared to Sticky Bone","status":"UNKNOWN","sponsor":"Cairo University","startDate":"2023-04","conditions":"Bone Quality Assessment, Preserved Sockets, Sodium Alendronate","enrollment":32},{"nctId":"NCT05490940","phase":"NA","title":"Sensory Recovery of Digital Nerves After Microsurgical Epineural Neurorrhaphy Alone or in Combination With Tisseel - RET","status":"UNKNOWN","sponsor":"Insel Gruppe AG, University Hospital Bern","startDate":"2023-03-01","conditions":"Digital Nerve Injuries","enrollment":74},{"nctId":"NCT05264922","phase":"PHASE2","title":"Stromal Vascular Fraction (SVF) Cells for Non-Operative Treatment of Small Rotator Cuff Tears","status":"WITHDRAWN","sponsor":"AdventHealth","startDate":"2022-01-09","conditions":"Rotator Cuff Tears","enrollment":""},{"nctId":"NCT03766555","phase":"NA","title":"Microwave Ablation Versus Liver Resection For Early Hepatocellular Carcinoma in Patients With Borderline Liver Function","status":"UNKNOWN","sponsor":"Chinese University of Hong Kong","startDate":"2018-05-21","conditions":"Carcinoma, Hepatocellular","enrollment":76},{"nctId":"NCT02488135","phase":"NA","title":"Management of Persistent Epistaxis Using Floseal Hemostatic Matrix","status":"COMPLETED","sponsor":"University of Alberta","startDate":"2015-07-01","conditions":"Epistaxis","enrollment":26},{"nctId":"NCT04839848","phase":"","title":"Chronic Postoperative Pain After the Lichtenstein Groin Hernioplasty","status":"COMPLETED","sponsor":"Karolinska Institutet","startDate":"2012-09-01","conditions":"Hernia, Inguinal, Hernia, Femoral, Postoperative Pain","enrollment":80733},{"nctId":"NCT03755219","phase":"","title":"Mesh and Mesh Fixation in Laparoscopic Groin Hernia Surgery","status":"COMPLETED","sponsor":"Bengt Novik","startDate":"2005-01-01","conditions":"Hernia, Inguinal, Surgical Mesh, Laparoscopy","enrollment":38450},{"nctId":"NCT05613335","phase":"NA","title":"Crestal Sinus Technique Using Autologous Fibrin Glue Vs Sticky Bone With Simultaneous Implant Insertion.","status":"UNKNOWN","sponsor":"Mansoura University","startDate":"2020-10-18","conditions":"Missed Upper Posterior Teeth","enrollment":10},{"nctId":"NCT01649505","phase":"NA","title":"Fibrin Sealant in Preventing Fluid Build Up During Surgery in Patients Undergoing Breast Reconstruction","status":"TERMINATED","sponsor":"OHSU Knight Cancer Institute","startDate":"2011-01","conditions":"Breast Cancer, Perioperative/Postoperative Complications","enrollment":2},{"nctId":"NCT03321201","phase":"NA","title":"Cauterization Versus ﬁbrin Glue for Conjunctival Autografting in Primary Pterygium Surgery","status":"RECRUITING","sponsor":"University of Split, School of Medicine","startDate":"2018-05-08","conditions":"Pterygium of Conjunctiva and Cornea","enrollment":164},{"nctId":"NCT04666051","phase":"NA","title":"Fibrin Glue in Inguinal Lymphadenectomy","status":"COMPLETED","sponsor":"Menoufia University","startDate":"2015-05","conditions":"Seroma","enrollment":32},{"nctId":"NCT02449005","phase":"PHASE1, PHASE2","title":"Autologous Alveolar Bone Marrow Mesenchymal Stem Cells for the Reconstruction of Infrabony Periodontal Defects","status":"COMPLETED","sponsor":"Aristotle University Of Thessaloniki","startDate":"2014-03","conditions":"Chronic Periodontitis","enrollment":30},{"nctId":"NCT02953145","phase":"PHASE4","title":"The Use of Fibrin Sealant to Reduce Post Operative Pain in Cleft Palate Surgery","status":"WITHDRAWN","sponsor":"University of Alberta","startDate":"2019-09-01","conditions":"Cleft Palate","enrollment":""},{"nctId":"NCT05051332","phase":"PHASE3","title":"Phase 3 Clinical Trial of CartiLife® in Korea","status":"UNKNOWN","sponsor":"Biosolution Co., Ltd.","startDate":"2020-03-19","conditions":"Articular Cartilage Defect, Articular Cartilage Degeneration","enrollment":104},{"nctId":"NCT05358977","phase":"PHASE2, PHASE3","title":"Fibrin Sealant in Eyelid Surgery","status":"UNKNOWN","sponsor":"University of Calgary","startDate":"2022-05","conditions":"Blepharoptosis, Ecchymosis; Eyelid","enrollment":30},{"nctId":"NCT04151017","phase":"NA","title":"Efficacy of Autologous Fibrin Glue in Pterygium","status":"COMPLETED","sponsor":"Hospital de Clinicas de Porto Alegre","startDate":"2019-06-12","conditions":"Pterygium","enrollment":64},{"nctId":"NCT03920306","phase":"PHASE4","title":"A Prospective Evaluation of Non-Operative Treatments for Gastrocutaneous Fistulae in Children","status":"UNKNOWN","sponsor":"University of British Columbia","startDate":"2019-04-01","conditions":"Gastrocutaneous Fistula, Gastrostomy Complications","enrollment":100},{"nctId":"NCT03776669","phase":"NA","title":"Laparoscopic Sleeve Gastrectomy With or Without Hiatal Hernia Repair in Morbidly Obese Patients","status":"UNKNOWN","sponsor":"National Taiwan University Hospital","startDate":"2019-01-09","conditions":"Morbid Obesity, Hiatal Hernia, Gastroesophageal Reflux Disease","enrollment":70},{"nctId":"NCT02298023","phase":"PHASE2","title":"Treatment of Tendon Injury Using Allogenic Adipose-derived Mesenchymal Stem Cells (Rotator Cuff Tear)","status":"COMPLETED","sponsor":"Seoul National University Hospital","startDate":"2014-09","conditions":"Rotator Cuff Tear","enrollment":24},{"nctId":"NCT03910374","phase":"NA","title":"Role of Leukocyte- and Platelet-Rich Fibrin Membranes in Endoscopic Endonasal Skull Base Reconstruction","status":"UNKNOWN","sponsor":"Universitaire Ziekenhuizen KU Leuven","startDate":"2018-11-01","conditions":"Cranial Sutures; Closure","enrollment":220},{"nctId":"NCT03529266","phase":"PHASE2","title":"Study of Porcine Fibrin Sealant in Preventing Cervical Anastomotic Leakage for Esophageal or Junctional Carcinoma.","status":"COMPLETED","sponsor":"Sun Yat-sen University","startDate":"2018-06-01","conditions":"Esophageal Cancer, Gastroesophageal Junction Cancer, Anastomotic Leak","enrollment":57},{"nctId":"NCT04932629","phase":"EARLY_PHASE1","title":"To Evaluate the Clinical Safety and Efficacy of Limbal Stem Cell for Treatment of Superficial Corneal Pathologies\".","status":"UNKNOWN","sponsor":"L.V. Prasad Eye Institute","startDate":"2021-07","conditions":"Corneal Scars and Opacities","enrollment":20},{"nctId":"NCT03276975","phase":"PHASE2","title":"A Randomized Trial of CT Fluoroscopy-guided Targeted Autologous Blood and Fibrin Glue Patching for Treatment","status":"COMPLETED","sponsor":"Duke University","startDate":"2017-12-18","conditions":"Cerebrospinal Fluid Leaks","enrollment":15},{"nctId":"NCT04889963","phase":"EARLY_PHASE1","title":"Regeneration of Posterior Cruciate Ligament Injury Using Hypoxic Conditioned Allogenic Adipose Mesenchymal Stem Cell and Condition Medium","status":"UNKNOWN","sponsor":"Gadjah Mada University","startDate":"2021-01-01","conditions":"Adypose Mesenchimal Stem Cell, Ligament Rupture, Ligament Derived Conditined Medium","enrollment":16},{"nctId":"NCT03993067","phase":"NA","title":"Hemopatch as a Tool to Prevent Biliary Fistula in Liver Surgery.","status":"COMPLETED","sponsor":"University of Milan","startDate":"2018-11-15","conditions":"Biliary Fistula, Surgery","enrollment":220},{"nctId":"NCT04805463","phase":"NA","title":"Different Platelet Concentrates After Gingivectomy and Gingivoplasty Evaluation of Its Effect on Early Wound Healing.","status":"COMPLETED","sponsor":"Inonu University","startDate":"2020-01-01","conditions":"Wound Heal, Gingival Overgrowth, Gingival Enlargement","enrollment":19},{"nctId":"NCT03564535","phase":"NA","title":"Comparison of Self Fixating Mesh to Mesh Fixation With Metallic Tacks in Laparoscopic Inguinal Hernia Repair","status":"UNKNOWN","sponsor":"All India Institute of Medical Sciences, Bhubaneswar","startDate":"2018-04-18","conditions":"Inguinal Hernia, Adult","enrollment":112},{"nctId":"NCT04621799","phase":"PHASE2, PHASE3","title":"Fibrin for Chronic Multi-level Discogenic Low Back Pain","status":"UNKNOWN","sponsor":"Pauza, Kevin, MD","startDate":"2018-06-11","conditions":"Low Back Pain, Disc Disease, Disc Degeneration","enrollment":400},{"nctId":"NCT01684020","phase":"PHASE2","title":"A Study Evaluating the Efficacy and Safety of ARTISS Human Fibrin Sealant as Used in External Rhinoplasty","status":"COMPLETED","sponsor":"DeNova Research","startDate":"2012-11-28","conditions":"Subjects Requesting and Requiring an Open Rhinoplasty","enrollment":10},{"nctId":"NCT02924922","phase":"NA","title":"Assessment of Oncological and Functional Outcomes After Robot Assisted Partial Nephrectomy Versus Laparoscopic Partial Nephrectomy","status":"COMPLETED","sponsor":"Luzerner Kantonsspital","startDate":"2016-05","conditions":"Kidney Neoplasms","enrollment":85},{"nctId":"NCT02227706","phase":"PHASE3","title":"The Paediatric EVICEL® Soft Tissue and Parenchymal Organ Bleeding Study","status":"COMPLETED","sponsor":"Ethicon, Inc.","startDate":"2014-08-01","conditions":"Hemorrhage, Soft Tissue Bleeding","enrollment":40},{"nctId":"NCT04317924","phase":"NA","title":"Pneumostasis With Use of Bio-absorbable Mesh and Fibrin Sealant in Lung Resection","status":"WITHDRAWN","sponsor":"Boston Medical Center","startDate":"2020-10","conditions":"Air Leak From Lung","enrollment":""},{"nctId":"NCT03733639","phase":"PHASE4","title":"Tisseel® as a Reinforcement of Esophagojejunal Anastomoses","status":"UNKNOWN","sponsor":"Germans Trias i Pujol Hospital","startDate":"2020-07-21","conditions":"Gastric Cancer, Anastomotic Leak","enrollment":146}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":375,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Fibrin adhesive","genericName":"Fibrin adhesive","companyName":"Tigenix S.A.U.","companyId":"tigenix-s-a-u","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Fibrin adhesive acts as a biological glue that promotes hemostasis and tissue adhesion by mimicking the final stages of the coagulation cascade to form a stable fibrin clot. Used for Surgical hemostasis and tissue adhesion, Wound healing and tissue sealing in surgical applications.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}