{"id":"fexofenadine-comparator-montelukast","safety":{"commonSideEffects":[{"rate":"6-8","effect":"Headache"},{"rate":"2-3","effect":"Nausea"},{"rate":"1-2","effect":"Dyspepsia"},{"rate":"1-2","effect":"Fatigue"},{"rate":"1-2","effect":"Dizziness"}]},"_chembl":{"chemblId":"CHEMBL1200681","moleculeType":"Small molecule","molecularWeight":"608.18"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Fexofenadine competitively binds to peripheral H1 histamine receptors on mast cells and basophils, preventing histamine release and its downstream effects on smooth muscle contraction, vasodilation, and itching. Unlike first-generation antihistamines, it is highly selective for peripheral H1 receptors and does not significantly penetrate the central nervous system, resulting in minimal sedation.","oneSentence":"Fexofenadine is a selective H1-receptor antagonist that blocks histamine-mediated allergic responses without crossing the blood-brain barrier.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:12:28.062Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Allergic rhinitis (seasonal and perennial)"},{"name":"Chronic urticaria"}]},"trialDetails":[{"nctId":"NCT00045955","phase":"PHASE3","title":"Long-Term Safety Performance of Fexofenadine in Asthma","status":"COMPLETED","sponsor":"Sanofi","startDate":"2002-02","conditions":"Asthma","enrollment":1200}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Fexofenadine, Comparator = Montelukast","genericName":"Fexofenadine, Comparator = Montelukast","companyName":"Sanofi","companyId":"sanofi","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Fexofenadine is a selective H1-receptor antagonist that blocks histamine-mediated allergic responses without crossing the blood-brain barrier. Used for Allergic rhinitis (seasonal and perennial), Chronic urticaria.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}