{"id":"fex60-pe10","safety":{"commonSideEffects":[{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Nervousness or insomnia"},{"rate":null,"effect":"Dry mouth"},{"rate":null,"effect":"Tachycardia"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Fexofenadine blocks H1 histamine receptors to reduce itching, sneezing, and urticaria associated with allergies, while pseudoephedrine acts as an alpha-adrenergic agonist to constrict nasal blood vessels and relieve nasal congestion. This combination addresses both the allergic response and the mechanical obstruction of allergic rhinitis.","oneSentence":"FEX60/PE10 is a fixed-dose combination of fexofenadine (a selective H1-receptor antagonist) and pseudoephedrine (a sympathomimetic decongestant) that reduces allergic symptoms and nasal congestion.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:12:32.136Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Allergic rhinitis with nasal congestion"}]},"trialDetails":[{"nctId":"NCT02401191","phase":"PHASE3","title":"A Study Assessing the Safety and Effectiveness of FEX60/PE10 Fixed Combination Tablet in Patients With Allergic Rhinitis","status":"COMPLETED","sponsor":"Sanofi","startDate":"2015-03","conditions":"Rhinitis Allergic","enrollment":105}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"FEX60/PE10","genericName":"FEX60/PE10","companyName":"Sanofi","companyId":"sanofi","modality":"Small molecule","firstApprovalDate":"","aiSummary":"FEX60/PE10 is a fixed-dose combination of fexofenadine (a selective H1-receptor antagonist) and pseudoephedrine (a sympathomimetic decongestant) that reduces allergic symptoms and nasal congestion. Used for Allergic rhinitis with nasal congestion.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}