{"id":"ferric-hydroxide","rwe":[{"pmid":"41523699","year":"2025","title":"Comparison of Two Oral Iron Formulations for Iron Deficiency and Iron Deficiency Anemia in Inflammatory Bowel Disease: A Prospective Study.","finding":"","journal":"GE Portuguese journal of gastroenterology","studyType":"Clinical Study"},{"pmid":"40592162","year":"2025","title":"One-step carbonate-assisted in situ crosslinking of Fe(OH)(3)-Alginate for enhanced removal of Se and As from sulfate-rich wastewater.","finding":"","journal":"Journal of environmental management","studyType":"Clinical Study"},{"pmid":"40344896","year":"2025","title":"From effluent to fertilizer: Phosphorus recovery and reuse using granulated iron-oxyhydroxide-montmorillonite composites.","finding":"","journal":"The Science of the total environment","studyType":"Clinical Study"},{"pmid":"40142135","year":"2025","title":"Investigation of Solution Microstructure in Ferric Sulfate Coagulation-Assisted Precipitation of Fluoride Ions.","finding":"","journal":"Molecules (Basel, Switzerland)","studyType":"Clinical Study"},{"pmid":"39971277","year":"2025","title":"Effects of Aging on the Severity of Liver Injury in Mice With Iron Overload.","finding":"","journal":"Journal of gastroenterology and hepatology","studyType":"Clinical Study"}],"tags":[{"label":"ferric hydroxide","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"B03AB04","category":"atc"},{"label":"Active","category":"status"}],"phase":"phase_2","safety":{"safetySignals":[{"llr":739.414,"date":"","count":89,"signal":"Arteriovenous fistula site complication","source":"DrugCentral FAERS","actionTaken":"Reported 89 times (LLR=739)"},{"llr":468.959,"date":"","count":125,"signal":"Hospitalisation","source":"DrugCentral FAERS","actionTaken":"Reported 125 times (LLR=469)"},{"llr":172.344,"date":"","count":48,"signal":"Angina pectoris","source":"DrugCentral FAERS","actionTaken":"Reported 48 times (LLR=172)"}],"drugInteractions":[{"url":"/drug/dolutegravir","drug":"dolutegravir","action":"Monitor closely","effect":"May interact with Dolutegravir, Iron","source":"DrugCentral","drugSlug":"dolutegravir"},{"url":"/drug/enoxacin","drug":"enoxacin","action":"Monitor closely","effect":"May interact with Enoxacin, Iron","source":"DrugCentral","drugSlug":"enoxacin"},{"url":"/drug/levodopa","drug":"levodopa","action":"Monitor closely","effect":"May interact with Iron, Levodopa","source":"DrugCentral","drugSlug":"levodopa"},{"url":"/drug/levofloxacin","drug":"levofloxacin","action":"Monitor closely","effect":"May interact with Iron, Levofloxacin","source":"DrugCentral","drugSlug":"levofloxacin"},{"url":"/drug/levothyroxine-sodium","drug":"levothyroxine sodium","action":"Monitor closely","effect":"May interact with Iron, Levothyroxine Sodium","source":"DrugCentral","drugSlug":"levothyroxine-sodium"},{"url":"/drug/lomefloxacin","drug":"lomefloxacin","action":"Monitor closely","effect":"May interact with Iron, Lomefloxacin","source":"DrugCentral","drugSlug":"lomefloxacin"},{"url":"/drug/minocycline","drug":"minocycline","action":"Monitor closely","effect":"May interact with Iron, Minocycline","source":"DrugCentral","drugSlug":"minocycline"},{"url":"/drug/moxifloxacin","drug":"moxifloxacin","action":"Monitor closely","effect":"May interact with Iron, Moxifloxacin","source":"DrugCentral","drugSlug":"moxifloxacin"},{"url":"/drug/mycophenolate-mofetil","drug":"mycophenolate mofetil","action":"Monitor closely","effect":"May interact with Iron, Mycophenolate Mofetil","source":"DrugCentral","drugSlug":"mycophenolate-mofetil"},{"url":"/drug/norfloxacin","drug":"norfloxacin","action":"Monitor closely","effect":"May interact with Iron, Norfloxacin","source":"DrugCentral","drugSlug":"norfloxacin"},{"url":"/drug/ofloxacin","drug":"ofloxacin","action":"Monitor closely","effect":"May interact with Iron, Ofloxacin","source":"DrugCentral","drugSlug":"ofloxacin"}],"commonSideEffects":[{"effect":"Arteriovenous fistula site complication","drugRate":"LLR 739","severity":"serious"},{"effect":"Hospitalisation","drugRate":"LLR 469","severity":"common"},{"effect":"Angina pectoris","drugRate":"LLR 172","severity":"common"}]},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"ferric trihydroxide","offLabel":[],"synonyms":["ferric hydroxide","ferric trihydroxide"],"timeline":[],"approvals":[],"brandName":"Ferric Trihydroxide","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"ferric hydroxide","explanation":"Imagine your body has a 'bucket' that stores iron, and sometimes this bucket gets too full. Ferric Trihydroxide helps to remove some of the excess iron from the bucket, which can help alleviate symptoms associated with iron overload.","oneSentence":"Ferric Trihydroxide works by binding to iron in the body, potentially helping to remove excess iron and alleviate associated conditions.","technicalDetail":"Ferric Trihydroxide binds to iron in the gastrointestinal tract, forming an insoluble complex that is then excreted from the body, thereby reducing the amount of available iron."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/4539","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=FERRIC%20HYDROXIDE","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=FERRIC HYDROXIDE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T11:30:13.049848","biosimilars":[],"competitors":[{"drugName":"sucroferric oxyhydroxide","drugSlug":"sucroferric-oxyhydroxide","fdaApproval":"2013-11-27","relationship":"same-class"},{"drugName":"ferric maltol","drugSlug":"ferric-maltol","fdaApproval":"2019-07-25","patentExpiry":"Oct 23, 2035","patentStatus":"Patent protected","relationship":"same-class"}],"genericName":"ferric hydroxide","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"sucroferric-oxyhydroxide","brandName":"sucroferric oxyhydroxide","genericName":"sucroferric oxyhydroxide","approvalYear":"2013","relationship":"same-class"},{"drugId":"ferric-maltol","brandName":"ferric maltol","genericName":"ferric maltol","approvalYear":"2019","relationship":"same-class"}],"trialDetails":[{"nctId":"NCT07391371","phase":"PHASE4","title":"Alternate-day Versus Daily Oral Iron Therapy in Children With Iron Deficiency Anaemia","status":"NOT_YET_RECRUITING","sponsor":"University of Medicine, Mandalay","startDate":"2026-02-01","conditions":["Iron Deficiency Anemia"],"enrollment":60,"completionDate":"2027-01-31"},{"nctId":"NCT06437080","phase":"NA","title":"Hypoferritinemia Without Anemia Among Reproductive Age Females","status":"ACTIVE_NOT_RECRUITING","sponsor":"Akram Medical Complex","startDate":"2022-10-10","conditions":["Hypoferritenemia Without Anemia (HWA)","Iron Deficiency Without Anemia)"],"enrollment":1331,"completionDate":"2025-04"},{"nctId":"NCT06631612","phase":"PHASE4","title":"Daily Versus Alternate Day Regimen of Iron Supplementation in Children with Iron Deficiency Anemia","status":"ACTIVE_NOT_RECRUITING","sponsor":"Ain Shams University","startDate":"2024-01-01","conditions":["Iron Deficiency Anemia Treatment"],"enrollment":72,"completionDate":"2025-03"},{"nctId":"NCT06542393","phase":"PHASE2","title":"PBM as Strategy to CABG Anemic Patients Bypass Graft (CABG)","status":"RECRUITING","sponsor":"Federal University of São Paulo","startDate":"2024-06-01","conditions":["Anemia","Coronary Disease","Coronary Artery Disease","Coronary Stenosis","Coronary Occlusion","Systemic Inflammatory Response","Bleeding","Epigenetic Disorder"],"enrollment":120,"completionDate":"2026-06-01"},{"nctId":"NCT03933813","phase":"PHASE1,PHASE2","title":"Evaluation and Treatment of Iron Deficiency in Ovarian Cancer Patients","status":"TERMINATED","sponsor":"University of Wisconsin, Madison","startDate":"2019-07-29","conditions":["Epithelial Ovarian Cancer","Anemia","Iron Deficiency Anemia"],"enrollment":9,"completionDate":"2021-11-22"},{"nctId":"NCT04640168","phase":"PHASE3","title":"Adaptive COVID-19 Treatment Trial 4 (ACTT-4)","status":"COMPLETED","sponsor":"National Institute of Allergy and Infectious Diseases (NIAID)","startDate":"2020-12-02","conditions":["COVID-19"],"enrollment":1010,"completionDate":"2021-06-18"},{"nctId":"NCT04401579","phase":"PHASE3","title":"Adaptive COVID-19 Treatment Trial 2 (ACTT-2)","status":"COMPLETED","sponsor":"National Institute of Allergy and Infectious Diseases (NIAID)","startDate":"2020-05-08","conditions":["COVID-19"],"enrollment":1033,"completionDate":"2020-07-31"},{"nctId":"NCT04862715","phase":"PHASE4","title":"The Iron and Muscle Study","status":"COMPLETED","sponsor":"King's College Hospital NHS Trust","startDate":"2019-04-26","conditions":["CKD Stage 3","CKD Stage 4","Iron-deficiency"],"enrollment":75,"completionDate":"2022-02-21"},{"nctId":"NCT04491916","phase":"NA","title":"Iron Therapy in Patients With End-Stage Renal Disease","status":"UNKNOWN","sponsor":"Kaohsiung Medical University Chung-Ho Memorial Hospital","startDate":"2020-04-01","conditions":["End-stage Renal Disease","Anemia","Cardiovascular Risk Factor","Inflammation"],"enrollment":200,"completionDate":"2022-12-31"},{"nctId":"NCT04225728","phase":"PHASE4","title":"Evaluation on Performance and Oxydative Stress in Patient With Iron deficIency and Stable Heart Failure Study","status":"COMPLETED","sponsor":"CN NGANOU-GNINDJIO, MD, MSc","startDate":"2017-12-01","conditions":["Chronic Heart Failure (CHF)","Iron Deficiency"],"enrollment":45,"completionDate":"2018-06-01"},{"nctId":"NCT03748043","phase":"PHASE4","title":"the Effectiveness of Lactoferrin in Treatment of Iron Deficiency Anemia in Children With Chronic Tonsillitis","status":"UNKNOWN","sponsor":"South Valley University","startDate":"2019-02-21","conditions":["Iron-deficiency"],"enrollment":100,"completionDate":"2019-05-30"},{"nctId":"NCT02151643","phase":"PHASE2","title":"Study to Evaluate the Efficacy and Safety of PT20 in Subjects With Hyperphosphataemia and Dialysis Dependent Chronic Kidney Disease","status":"COMPLETED","sponsor":"Phosphate Therapeutics","startDate":"2014-05-07","conditions":["Hyperphosphataemia"],"enrollment":153,"completionDate":"2015-03-18"},{"nctId":"NCT01991574","phase":"EARLY_PHASE1","title":"Effect of the Consumption of Ferric Hydroxide Adipate on Urinary Phosphorus Excretion.","status":"COMPLETED","sponsor":"Medical Research Council","startDate":"2009-04","conditions":["Healthy","Chronic Kidney Diseases"],"enrollment":30,"completionDate":"2009-10"},{"nctId":"NCT01168505","phase":"PHASE2","title":"Iron Supplement in the Prevention of Anemia in Female Breast Cancer Patients","status":"UNKNOWN","sponsor":"Instituto do Cancer do Estado de São Paulo","startDate":"2010-05","conditions":["Breast Cancer"],"enrollment":100,"completionDate":"2014-12"},{"nctId":"NCT01443624","phase":"NA","title":"Evaluation of Oxidative Stress Induced by Iron Injection in Healthy Volunteers and Critical Care Patients","status":"COMPLETED","sponsor":"Assistance Publique - Hôpitaux de Paris","startDate":"2011-10","conditions":["Critical Illness"],"enrollment":80,"completionDate":"2013-08"},{"nctId":"NCT01078818","phase":"PHASE4","title":"Oral and Intravenous Iron in Patients Postoperative Cardiovascular Surgery Under Extracorporeal Circulation","status":"COMPLETED","sponsor":"Fundación Canaria Rafael Clavijo para la Investigación Biomédica","startDate":"2007-05","conditions":["Anaemia"],"enrollment":159,"completionDate":"2009-05"}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NDDF":"007463","UNII":"2UA751211N","CHEBI":"CHEBI:135985","RXNORM":"1428835","UMLSCUI":"C0060236","ChEMBL_ID":"CHEMBL3707285","DRUGBANK_ID":"DB13423","PUBCHEM_CID":"445709","MESH_SUPPLEMENTAL_RECORD_UI":"C021024"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":401,"therapeuticAreas":["Gastroenterology"],"atcClassification":{"source":"DrugCentral","atcCode":"B03AB04","allCodes":["B03AB04"]},"biosimilarFilings":[],"recentPublications":[{"date":"2025 Nov 19","pmid":"41523699","title":"Comparison of Two Oral Iron Formulations for Iron Deficiency and Iron Deficiency Anemia in Inflammatory Bowel Disease: A Prospective Study.","journal":"GE Portuguese journal of gastroenterology"},{"date":"2025 Aug","pmid":"40592162","title":"One-step carbonate-assisted in situ crosslinking of Fe(OH)(3)-Alginate for enhanced removal of Se and As from sulfate-rich wastewater.","journal":"Journal of environmental management"},{"date":"2025 Jun 15","pmid":"40344896","title":"From effluent to fertilizer: Phosphorus recovery and reuse using granulated iron-oxyhydroxide-montmorillonite composites.","journal":"The Science of the total environment"},{"date":"2025 Mar 18","pmid":"40142135","title":"Investigation of Solution Microstructure in Ferric Sulfate Coagulation-Assisted Precipitation of Fluoride Ions.","journal":"Molecules (Basel, Switzerland)"},{"date":"2025 Apr","pmid":"39971277","title":"Effects of Aging on the Severity of Liver Injury in Mice With Iron Overload.","journal":"Journal of gastroenterology and hepatology"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Ferric Trihydroxide, also known as FERRIC HYDROXIDE, is a small molecule drug in the ferric hydroxide class. Its mechanism of action and approved indications are not specified in the provided facts. As a result, there is limited information available on its commercial status, key safety considerations, or how it works. Further research is necessary to determine its target, half-life, bioavailability, and other relevant details. It is essential to consult reliable sources for accurate information on this compound.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":false,"safety":true,"trials":true,"score":3}}