{"id":"ferric-59fe-citrate","rwe":[{"pmid":"10691965","year":"2000","title":"The role of the membrane-bound tumour antigen, melanotransferrin (p97), in iron uptake by the human malignant melanoma cell.","finding":"","journal":"European journal of biochemistry","studyType":"Clinical Study"},{"pmid":"10429185","year":"1999","title":"The effect of intracellular iron concentration and nitrogen monoxide on Nramp2 expression and non-transferrin-bound iron uptake.","finding":"","journal":"European journal of biochemistry","studyType":"Clinical Study"},{"pmid":"9989766","year":"1999","title":"Activation of an iron uptake mechanism from transferrin in hepatocytes by small-molecular-weight iron complexes: implications for the pathogenesis of iron-overload disease.","finding":"","journal":"The Journal of laboratory and clinical medicine","studyType":"Clinical Study"},{"pmid":"9688655","year":"1998","title":"Mechanisms of ferric citrate uptake by human hepatoma cells.","finding":"","journal":"The American journal of physiology","studyType":"Clinical Study"},{"pmid":"7488642","year":"1995","title":"Identification of a mechanism of iron uptake by cells which is stimulated by hydroxyl radicals generated via the iron-catalysed Haber-Weiss reaction.","finding":"","journal":"Biochimica et biophysica acta","studyType":"Clinical Study"}],"tags":[{"label":"ferric (59Fe) citrate","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"V09XX04","category":"atc"},{"label":"Active","category":"status"}],"phase":"unknown","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"iron-59 citrate","offLabel":[],"synonyms":["ferric (59Fe) citrate","Iron-59 citrate"],"timeline":[],"approvals":[],"brandName":"Iron-59 Citrate","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"ferric (59Fe) citrate","explanation":"Think of iron like a key that helps your body make healthy red blood cells. When you're low on iron, your body can't make enough red blood cells, leading to fatigue, weakness, and other symptoms. Iron-59 Citrate helps fill the iron gap, allowing your body to produce healthy red blood cells and alleviate these symptoms.","oneSentence":"Iron-59 Citrate works by providing the body with iron, a crucial element for healthy red blood cells.","technicalDetail":"Iron-59 Citrate is a ferric (59Fe) citrate compound that is absorbed by the body, where it is reduced to ferrous iron and incorporated into hemoglobin, allowing for the production of healthy red blood cells."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/4537","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=ferric (59Fe) citrate","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T11:26:04.983400","biosimilars":[],"competitors":[{"drugName":"cyanocobalamin (57Co)","drugSlug":"cyanocobalamin-(57co)","fdaApproval":"1968-06-21","relationship":"same-class"}],"genericName":"ferric (59fe) citrate","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"cyanocobalamin-(57co)","brandName":"cyanocobalamin (57Co)","genericName":"cyanocobalamin (57Co)","approvalYear":"1968","relationship":"same-class"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"UMLSCUI":"C1273019","ChEMBL_ID":"CHEMBL3833349","DRUGBANK_ID":"DB13582","PUBCHEM_CID":"170848"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":6,"therapeuticAreas":["Hematology"],"atcClassification":{"source":"DrugCentral","atcCode":"V09XX04","allCodes":["V09XX04"]},"biosimilarFilings":[],"recentPublications":[{"date":"2000 Mar","pmid":"10691965","title":"The role of the membrane-bound tumour antigen, melanotransferrin (p97), in iron uptake by the human malignant melanoma cell.","journal":"European journal of biochemistry"},{"date":"1999 Jul","pmid":"10429185","title":"The effect of intracellular iron concentration and nitrogen monoxide on Nramp2 expression and non-transferrin-bound iron uptake.","journal":"European journal of biochemistry"},{"date":"1999 Feb","pmid":"9989766","title":"Activation of an iron uptake mechanism from transferrin in hepatocytes by small-molecular-weight iron complexes: implications for the pathogenesis of iron-overload disease.","journal":"The Journal of laboratory and clinical medicine"},{"date":"1998 Aug","pmid":"9688655","title":"Mechanisms of ferric citrate uptake by human hepatoma cells.","journal":"The American journal of physiology"},{"date":"1995 Nov 9","pmid":"7488642","title":"Identification of a mechanism of iron uptake by cells which is stimulated by hydroxyl radicals generated via the iron-catalysed Haber-Weiss reaction.","journal":"Biochimica et biophysica acta"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"unknown","modality":"Small Molecule","firstApprovalDate":"","aiSummary":"Iron-59 Citrate, also known as ferric (59Fe) citrate, is a small molecule drug in the ferric (59Fe) citrate class. Its exact target and indications are unknown, and its commercial status, including FDA approval and patent status, is also unclear. As a ferric (59Fe) citrate, it is likely used to treat iron deficiency or anemia, but more information is needed to confirm its specific use. The drug's half-life, bioavailability, and generic manufacturers are also unknown. Further research is necessary to fully understand its properties and applications.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}